The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
Open accessAbstract
In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor. Using a heterologous system, we show that Dsh is recruited selectively to the membrane by Fz but not DFz2, and this recruitment depends on the DEP domain but not the PDZ domain in Dsh. A mutation in the DEP domain impairs both membrane localization and the function of Dsh in PCP signaling, indicating that translocation is important for function. Further genetic and molecular analyses suggest that conserved domains in Dsh function differently during PCP and Wg signaling, and that divergent intracellular pathways are activated. We propose that Dsh has distinct roles in PCP and Wg signaling. The PCP signal may selectively result in focal Fz activation and asymmetric relocalization of Dsh to the membrane, where Dsh effects cytoskeletal reorganization to orient prehair initiation.
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Cites
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Self-citation
Cited by
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Self-citationLDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
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Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
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Metadata
- Authors
- Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-08-15
- Volume
- 12
- Issue
- 16
- Pages
- 2610-2622
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2120983879
- Cited by
- 659
- References
- 68
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. https://app.cochat.ai/papers/10.1101/gad.12.16.2610
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- Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998). Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes & Development. https://doi.org/10.1101/gad.12.16.2610
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
