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Exploring and Engineering the Cell Surface Interface
Abstract
Cells are inherently sensitive to local mesoscale, microscale, and nanoscale patterns of chemistry and topography. We review current approaches to control cell behavior through the nanoscale engineering of materials surfaces. Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.
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“They found that similar forces are generated even as the stiffness of the matrix is changed.”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [105]
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“Steinwechs et al. (105) quantified, for the first time, the forces resulting from a breast carcinoma cell that migrates within a 3D collagen fibril matrix.”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [105]
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Metadata
- Authors
- Stevens, M. M., & George, J. H.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Stevens, Molly M.
- Venue
- Science
- Published
- 2005-11-18
- Volume
- 310
- Issue
- 5751
- Pages
- 1135-1138
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982769493
- Cited by
- 2,607
- References
- 64
- Citations by year
- 2026: 30 · 2025: 57 · 2024: 57 · 2023: 90 · 2022: 91 · 2021: 117 · 2020: 132 · 2019: 126 · 2018: 165 · 2017: 166 · 2016: 185 · 2015: 145 · 2014: 202 · 2013: 177 · 2012: 177
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Engineering and Physical Sciences Research Council (EP/C520742/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- nanoscale surface patterning, cell-material interactions, cell behavior control, surface topography, surface chemistry, biomedical implants, tissue regeneration, 3D scaffolds
- MeSH terms
- Animals, Biocompatible Materials, Cell Membrane, Cell Physiological Phenomena, Extracellular Matrix, Forecasting, Humans, Surface Properties, Tissue Engineering, Nanotechnology
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