The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice
Abstract
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head , which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3 . Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.
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Cites
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Cited by
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Wound repair and regeneration: Mechanisms, signaling, and translation
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Cancer as an overhealing wound: an old hypothesis revisited
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Evolution of Gene Regulatory Networks Controlling Body Plan Development
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Mechanisms Regulating Epithelial Stratification
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Metadata
- Authors
- Ting, S. B., Caddy, J., Hislop, N., Wilanowski, T., Auden, A., Zhao, L.-L., Ellis, S., Kaur, P., Uchida, Y., Holleran, W. M., Elias, P. M., Cunningham, J. M., & Jane, S. M.
- Venue
- Science
- Published
- 2005-04-15
- Volume
- 308
- Issue
- 5720
- Pages
- 411-413
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2107638340
- Cited by
- 310
- References
- 31
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice. https://app.cochat.ai/papers/10.1126/science.1107511
- The paper
- Ting, S. B., Caddy, J., Hislop, N., Wilanowski, T., Auden, A., Zhao, L.-L., Ellis, S., Kaur, P., Uchida, Y., Holleran, W. M., Elias, P. M., Cunningham, J. M., & Jane, S. M. (2005). A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice. Science. https://doi.org/10.1126/science.1107511
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
