The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat
Abstract
Using an active approach to preventing biofilm formation, we implemented a microfluidic bioreactor that enables long-term culture and monitoring of extremely small populations of bacteria with single-cell resolution. We used this device to observe the dynamics of Escherichia coli carrying a synthetic “population control” circuit that regulates cell density through a feedback mechanism based on quorum sensing. The microfluidic bioreactor enabled long-term monitoring of unnatural behavior programmed by the synthetic circuit, which included sustained oscillations in cell density and associated morphological changes, over hundreds of hours.
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Citations
Cites
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The Theory of the Chemostat: Dynamics of Microbial Competition
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The Theory of the Chemostat: Dynamics of Microbial Competition.
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Programmed population control by cell–cell communication and regulated killing
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Self-citationExperimental Studies of Natural Selection in Bacteria
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Membrane‐aerated microbioreactor for high‐throughput bioprocessing
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Cited by
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
El-Ali, J., Sorger, P. K., & Jensen, K. F. (2006) · Nature · doi:10.1038/nature05063 · Cited by 2,102
Stochastic protein expression in individual cells at the single molecule level
Cai, L., Friedman, N., & Xie, X. S. (2006) · Nature · doi:10.1038/nature04599 · Cited by 1,145
Synthetic biology: new engineering rules for an emerging discipline
Andrianantoandro, E., Basu, S., Karig, D. K., & Weiss, R. (2006) · Molecular Systems Biology · doi:10.1038/msb4100073 · Cited by 1,081
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
Metadata
- Authors
- Balagaddé, F. K., You, L., Hansen, C. L., Arnold, F. H., & Quake, S. R.
- Venue
- Science
- Published
- 2005-07
- Volume
- 309
- Issue
- 5731
- Pages
- 137-140
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060603511
- Cited by
- 599
- References
- 15
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Balagaddé, F. K., You, L., Hansen, C. L., Arnold, F. H., & Quake, S. R. (2005). Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat. Science. https://doi.org/10.1126/science.1109173
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
