The DOI matches its Crossref record.
Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila
Abstract
Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872
Reproduction–Immunity Trade-Offs in Insects
Schwenke, R. A., Lazzaro, B. P., & Wolfner, M. F. (2016) · Annual Review of Entomology · doi:10.1146/annurev-ento-010715-023924 · Cited by 632
Regulatory Pathways Controlling Female Insect Reproduction
Roy, S., Saha, T. T., Zou, Z., & Raikhel, A. S. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-020117-043258 · Cited by 567
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy
Nakada, D., Oguro, H., Levi, B. P., Ryan, N., Kitano, A., Saitoh, Y., Takeichi, M., Wendt, G. R., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature12932 · Cited by 408
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331
Metadata
- Authors
- LaFever, L., & Drummond-Barbosa, D.
- Venue
- Science
- Published
- 2005-08-12
- Volume
- 309
- Issue
- 5737
- Pages
- 1071-1073
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983880033
- Cited by
- 320
- References
- 0
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila. https://app.cochat.ai/papers/10.1126/science.1111410
- The paper
- LaFever, L., & Drummond-Barbosa, D. (2005). Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila. Science. https://doi.org/10.1126/science.1111410
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
