The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Pains of Endometriosis
Abstract
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.
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In the citing paper
“Sensory fibers whose branches innervate ectopic growths immunostain with antibodies to calcitonin gene-related peptide (CGRP) (Berkley et al., 2004(Berkley et al., , 2005)), indicating that the CGRP-positive fibers include C-fiber nociceptors (Snider and McMahon, 1998).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“characteristics of the ectopic growths' newly formed nerve supply and resultant two-way communication between the growths and CNS contribute to the variable association between the growths and pain”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Direct innervation of ectopic endometrial growths by sensory and sympathetic fibers was shown in endometriosis growths from a rat model (Berkley et al., 2004) and lesions from women (Berkley et al., 2005).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Our group discovered that ectopic growths harvested from ENDO rats and women with established endometriosis develop their own C-fiber (sensory afferent) and sympathetic (autonomic efferent) nerve supply.”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“The supply is derived from nerve fibers innervating nearby territories that sprout branches into the growths [10], [11].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“This innervation in the rat model, diagrammed in Fig. 1b, consists of branches of axons that sprout from pre-existing sensory neurons whose cell bodies are located in thoracic dorsal root ganglia (DRG) and from sympathetic neurons whose cell bodies are located in the coeliac ganglion (CG).”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
In the citing paper
“The ectopic growths in both the rat model and in women recruit their own sensory and sympathetic nerve supply [4,5].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
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“…sympathetic and sensory C- and A -fibers found in endometriotic cysts in rats and in layers of the endometrium and endometriotic lesions in women (Berkley et al., 2005; Tokushige, Markham, Russell, & Fraser, 2006; Tokushige, Markham, Russell, & Fraser, 2007; Zhang, Dmitrieva, Liu, McGinty, &…”
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Metadata
- Authors
- Berkley, K. J., Rapkin, A. J., & Papka, R. E.
- Affiliations
- Florida State University (US)
- ORCID
- Rapkin, Andrea J.
- Venue
- Science
- Published
- 2005-06-10
- Volume
- 308
- Issue
- 5728
- Pages
- 1587-1589
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068756641
- Cited by
- 455
- References
- 20
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 21 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 16 · 2016: 21 · 2015: 26 · 2014: 20 · 2013: 23 · 2012: 28
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK063937)
- National Institute of Neurological Disorders and Stroke (R01-NS-11892, R01 NS22526, R01NS022526, R01NS011892)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, pelvic pain, chronic pain, estrogen sensitivity, ectopic endometrium, innervation, central nervous system neurons, pain mechanisms
- MeSH terms
- Animals, Central Nervous System, Endometriosis, Female, Humans, Gonadotropin-Releasing Hormone, Neural Pathways, Neurons, Neurons, Afferent, Pain, Spinal Cord, Sympathetic Nervous System, Rats
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