The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Pains of Endometriosis
Abstract
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.
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In the citing paper
“Sensory fibers whose branches innervate ectopic growths immunostain with antibodies to calcitonin gene-related peptide (CGRP) (Berkley et al., 2004(Berkley et al., , 2005)), indicating that the CGRP-positive fibers include C-fiber nociceptors (Snider and McMahon, 1998).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“characteristics of the ectopic growths' newly formed nerve supply and resultant two-way communication between the growths and CNS contribute to the variable association between the growths and pain”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Direct innervation of ectopic endometrial growths by sensory and sympathetic fibers was shown in endometriosis growths from a rat model (Berkley et al., 2004) and lesions from women (Berkley et al., 2005).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Our group discovered that ectopic growths harvested from ENDO rats and women with established endometriosis develop their own C-fiber (sensory afferent) and sympathetic (autonomic efferent) nerve supply.”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“The supply is derived from nerve fibers innervating nearby territories that sprout branches into the growths [10], [11].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“This innervation in the rat model, diagrammed in Fig. 1b, consists of branches of axons that sprout from pre-existing sensory neurons whose cell bodies are located in thoracic dorsal root ganglia (DRG) and from sympathetic neurons whose cell bodies are located in the coeliac ganglion (CG).”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
In the citing paper
“The ectopic growths in both the rat model and in women recruit their own sensory and sympathetic nerve supply [4,5].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
Citations
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Effect of siRNA Against ß-NGF on Nerve Fibers of a Rat Model With Endometriosis
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Genetic variations of MUC17 are associated with endometriosis development and related infertility
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Stratton, P. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.06.044 · Cited by 23
“The ectopic endometrial tissue may be innervated and sensitive to estrogen ( 13 ).”
BackgroundLessey, B. A., Higdon, H. L., Miller, S., & Price, T. A. (2012) · Journal of Visualized Experiments · doi:10.3791/4313 · Cited by 23
The external genital endometriosis: theories and molecular investigations (a review)
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Saliminejad, K., Memariani, T., Ardekani, A. M., Kamali, K., Edalatkhah, H., Pahlevanzadeh, Z., & Khorshid, H. R. K. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.824956 · Cited by 22
Variability of serum IgG sialylation and galactosylation degree in women with advanced endometriosis
Sołkiewicz, K., Krotkiewski, H., Jędryka, M., & Kratz, E. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-85200-x · Cited by 22
Machado-Linde, F., Pelegrín, P., Sanchez-Ferrer, M., León, J., Cascales, P., & Parrilla, J. (2012) · Reproductive Sciences · doi:10.1177/1933719112446080 · Cited by 22
Vasoactive intestinal peptide is upregulated in women with endometriosis and chronic pelvic pain
Bourlev, V., Moberg, C., Ilyasova, N. A., Davey, E., Kallak, T. K., & Olovsson, M. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12857 · Cited by 21
Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development
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Baropodometry on women suffering from chronic pelvic pain - a cross-sectional study
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“The data obtained from this study, particularly given the established role of this forebrain region in reproductive processes, provide a baseline for our subsequent experiments using a rat model of endometriosis (Chadha andHubscher, 2006), a common condition among women which is associated with infertility and severe…”
ResultSyndecan-4 expression is upregulated in endometriosis and contributes to an invasive phenotype
Chelariu-Raicu, A., Wilke, C., Brand, M., Starzinski‐Powitz, A., Kiesel, L., Schüring, A. N., & Götte, M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.03.032 · Cited by 21
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“These uterine transplants over time produce innervated and vascularized cysts (Berkley et al., 2004; 2005) and symptoms similar to women including vaginal hyperalgesia (Berkley et al., 2007; McAllister et al., 2009, 2012) referred abdominal muscle hyperalgesia (Giamberardino et al., 2002;…”
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Dysmenorrhea: Risk Factors in Women with Endometriosis
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Is There a Role for Acupuncture in Endometriosis Pain, Or ‘endometrialgia’?
Lundeberg, T., & Lund, I. (2008) · Acupuncture in Medicine · doi:10.1136/aim.26.2.94 · Cited by 19
Nerve fibers and menstrual cycle in peritoneal endometriosis
Wang, G., Tokushige, N., & Fraser, I. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.150 · Cited by 18
Foda, A. A., & Aal, I. A. A. (2012) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2012.06.002 · Cited by 18
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Stovner, L. J., Ægidius, K. L., & Linde, M. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0209-z · Cited by 17
Arosh, J. A., Lee, J., & Banu, S. K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111446 · Cited by 17
Pelvic pain in women: clinical and scientific aspects
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Regional lymphatic spread in women with pelvic endometriosis
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LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction
Jiang, L., Zhang, M., Wang, S., Xiao, Y., Wu, J., Zhou, Y., & Fang, X. (2020) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738420976309 · Cited by 16
Effectiveness of ultrasound for endometriosis diagnosis
Chen-Dixon, K., Uzuner, C., Mak, J., & Condous, G. S. (2022) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000812 · Cited by 16
“It affects up to 10% of women [3] and in addition to pelvic pain [4] and/or infertility [5], it also affects patient’s personal relationships [6], sexual function [6], quality of life [7,8], mental health [9], energy [10] and productivity [8]; thus making it a significant economic burden to society [7] and a public he…”
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“This pathology is a debilitating condition, causing a significantly low quality of life (QoL) for individuals who are affected by it [32].”
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Wang, S., Cai, H., Dong, X., Fan, Q., Wang, L., Shao, X., & Zhang, L. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12491 · Cited by 16
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Gynecological Pain, Endometriosis, Visceral Disease, and the Viscero-Somatic Connection
Jarrell, J. F. (2008) · Journal of Musculoskeletal Pain · doi:10.1080/10582450801960131 · Cited by 16
Ortega-Gutiérrez, M., Muñoz-Gamez, A., & Girón‐Prieto, M. S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134757 · Cited by 19
“Any symptom that consistently worsens with the menstrual cycle should prompt consideration of endometriosis [7], although symptoms may also occur independently of the cycle due to potential central sensitization and a neuropathic component [2,6,29].”
Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis
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Endometriosis, infertility and occupational life: women's plea for recognition
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“Women with endometriosis also often have difficulty conceiving and often have to resort to assisted reproduction or surgery to achieve pregnancy [3, 4].”
BackgroundMicroanatomy and function of the eutopic endometrium in women with endometriosis
Al‐Jefout, M., Tokushige, N., Hey‐Cunningham, A. J., Manconi, F., Ng, C. H. M., Schulke, L., Berbic, M., Markham, R., & Is, F. (2008) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.4.1.61 · Cited by 15
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Peripheral and central neuroplasticity in a mouse model of endometriosis
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Endométriose et génétique : les gènes sont-ils responsables de la maladie ?
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“Les symptômes de la maladie sont dominés par des douleurs et une infertilité [3,4].”
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Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain
Pergolizzi, J. V., LeQuang, J. A., Coluzzi, F., El-Tallawy, S. N., Magnusson, P., Ahmed, R. S., Varrassi, G., & Porpora, M. G. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2425727 · Cited by 15
“In an animal study, surgically induced endometriosis results in nerve growth in the endometriotic lesion, [26] suggesting that painful symptoms may result from the interaction between nerve and lesion [27].”
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“In 44 patients (86.3%), endometriosis was diagnosed and classiWed by surgery according to the revised classiWcation of the American Society of Reproductive Medicine [ 10 ] (rASRM I = 11; II = 6; III = 9; IV = 18).”
MethodInfluentialEndométriose et douleurs pelvipérinéales chroniques
Roman, H., Bourdel, N., Rigaud, J., Delavierre, D., Labat, J.-J., & Sibert, L. (2010) · The French Journal of Urology · doi:10.1016/j.purol.2010.08.007 · Cited by 13
Characteristics of histologically confirmed endometriosis in cynomolgus monkeys
Nishimoto-Kakiuchi, A., Netsu, S., Matsuo, S., Hayashi, S., Ito, T., Okabayashi, S., Yasmin, L., Yuzawa, K., Kondoh, O., Kato, A., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew209 · Cited by 13
Association of endometriosis with Sjögren's syndrome: Genetic insights (Review)
Zervou, M. I., Tarlatzis, B. C., Grimbizis, G., Spandidos, D. A., Niewold, T. B., & Goulielmos, G. N. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5344 · Cited by 17
The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity
Hondermarck, H., Huang, P. S., & Wagner, J. A. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00080 · Cited by 11
Lymph Node Involvement in Deep Infiltrating Intestinal Endometriosis: Does It Really Mean Anything?
Rossini, R., Monsellato, D., Bertolaccini, L., Pesci, A., Zamboni, G., Ceccaroni, M., & Ruffo, G. (2016) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2016.03.021 · Cited by 12
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Epigenetic age provides insight into tissue origin in endometriosis
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“Exposure of primed trigeminal neurons in vivo or in vitro to a low dose of TRPA1 activator (4) increases neuronal excitability (5) and elicits migraine pain (6).”
Understanding sexual pain in endometriosis
Aerts, L., Grangier, L., Dällenbach, P., Wenger, J., Streuli, I., Bianchi‐Demicheli, F., & Pluchino, N. (2019) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.19.04379-x · Cited by 11
Effect of esophagus distention on urinary bladder function in rats
Kaddumi, E. G., Qnais, E. Y., & Allouh, M. Z. (2011) · Neurourology and Urodynamics · doi:10.1002/nau.21173 · Cited by 11
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A neural circuit for sex-dependent conditioned pain hypersensitivity in mice
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“Both female humans and rodents are more sensitive to pain than males 1,2 , which may be due to sex-speci fi c reproductive hormones, especially estrogen 52 – 55 .”
Fang, F., Gong, L., Wang, X., & Zhang, L. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370214564752 · Cited by 10
Pelvic pain after gonadotropin administration as a potential sign of endometriosis
Jun, S. H., & Lathi, R. B. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.054 · Cited by 10
Mathiasen, M., Egekvist, A. G., Kesmodel, U. S., Knudsen, U. B., & Seyer‐Hansen, M. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13468 · Cited by 10
The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population.
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Deep dyspareunia: a narrative review of impact on sexual function and quality of life
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Laparoscopic Posthysterectomy Vaginal Vault Excision for Chronic Pelvic Pain and Deep Dyspareunia
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A model for radiating leg pain of endometriosis
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“Endometriosis induced dysmenorrhea, infertility, intercourse pain and other symptoms could accompany with patients for up to decades or even a lifetime.([1]) Moreover, the symptoms will gradually be aggravated.”
BackgroundTowards an understanding of the molecular mechanisms of endometriosis-associated symptoms (Review)
Imanaka, S., Maruyama, S., Kimura, M., Nagayasu, M., & Kobayashi, H. (2020) · World Academy of Sciences Journal · doi:10.3892/wasj.2020.53 · Cited by 10
Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)
Zervou, M. I., Papageorgiou, L., Vlachakis, D., Spandidos, D. A., Eliopoulos, E., & Goulielmos, G. N. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.12983 · Cited by 8
Metadata
- Authors
- Berkley, K. J., Rapkin, A. J., & Papka, R. E.
- Affiliations
- Florida State University (US)
- ORCID
- Rapkin, Andrea J.
- Venue
- Science
- Published
- 2005-06-10
- Volume
- 308
- Issue
- 5728
- Pages
- 1587-1589
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068756641
- Cited by
- 455
- References
- 20
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 21 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 16 · 2016: 21 · 2015: 26 · 2014: 20 · 2013: 23 · 2012: 28
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK063937)
- National Institute of Neurological Disorders and Stroke (R01-NS-11892, R01 NS22526, R01NS022526, R01NS011892)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, pelvic pain, chronic pain, estrogen sensitivity, ectopic endometrium, innervation, central nervous system neurons, pain mechanisms
- MeSH terms
- Animals, Central Nervous System, Endometriosis, Female, Humans, Gonadotropin-Releasing Hormone, Neural Pathways, Neurons, Neurons, Afferent, Pain, Spinal Cord, Sympathetic Nervous System, Rats
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