The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Pains of Endometriosis
Abstract
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.
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In the citing paper
“Sensory fibers whose branches innervate ectopic growths immunostain with antibodies to calcitonin gene-related peptide (CGRP) (Berkley et al., 2004(Berkley et al., , 2005)), indicating that the CGRP-positive fibers include C-fiber nociceptors (Snider and McMahon, 1998).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“characteristics of the ectopic growths' newly formed nerve supply and resultant two-way communication between the growths and CNS contribute to the variable association between the growths and pain”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Direct innervation of ectopic endometrial growths by sensory and sympathetic fibers was shown in endometriosis growths from a rat model (Berkley et al., 2004) and lesions from women (Berkley et al., 2005).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Berkley et al., 2005
In the citing paper
“Our group discovered that ectopic growths harvested from ENDO rats and women with established endometriosis develop their own C-fiber (sensory afferent) and sympathetic (autonomic efferent) nerve supply.”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“The supply is derived from nerve fibers innervating nearby territories that sprout branches into the growths [10], [11].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [11]
In the citing paper
“This innervation in the rat model, diagrammed in Fig. 1b, consists of branches of axons that sprout from pre-existing sensory neurons whose cell bodies are located in thoracic dorsal root ganglia (DRG) and from sympathetic neurons whose cell bodies are located in the coeliac ganglion (CG).”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
In the citing paper
“The ectopic growths in both the rat model and in women recruit their own sensory and sympathetic nerve supply [4,5].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [5]
Citations
Cites
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Sinaii, N. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2715 · Cited by 620
Immune and glial cell factors as pain mediators and modulators
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Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease
Chapron, C. (2003) · Human Reproduction · doi:10.1093/humrep/deg152 · Cited by 311
Endometriosis is associated with central sensitization: a psychophysical controlled study
Bajaj, P. (2003) · The Journal of Pain · doi:10.1016/s1526-5900(03)00720-x · Cited by 247
Innervation of ectopic endometrium in a rat model of endometriosis
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Self-citationEstrogens in the Nervous System: Mechanisms and Nonreproductive Functions
Maggi, A. C., Ciana, P., Belcredito, S., & Vegeto, E. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032802.154945 · Cited by 212
Relationship between stage, site and morphological characteristics of pelvic endometriosis and pain
dell'Endometriosi, G. I. P. L. S. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2668 · Cited by 167
Role of the Posterolateral Cerebellum in Language
Gebhart, A. L., Petersen, S. E., & Thach, W. T. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb07577.x · Cited by 135
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Self-citationUsing Rats as a Research Model for the Study of Endometriosis
Sharpe-Timms, K. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02792.x · Cited by 90
Giamberardino, M. A., Laurentis, S. D., Affaitati, G., Lerza, R., Lapenna, D., & Vecchiet, L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01753-0 · Cited by 81
Pain management : a practical guide for clinicians
Weiner, R. (1998) · St. Lucie Press eBooks · Cited by 77
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Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum
Tulandi, T., Felemban, A., & Fong Chen, M. (2001) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60556-7 · Cited by 60
Estrogen Receptors in the Spinal Cord, Sensory Ganglia, and Pelvic Autonomic Ganglia
Papka, R. E., & Mowa, C. N. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)31003-4 · Cited by 55
Self-citationOptimizing Gonadotropin-Releasing Hormone Agonist Therapy in Women with Endometriosis
Olive, D. L. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403020-00003 · Cited by 38
Flagged first, then by citations
Research works printed but not linked: 1
- K. J. Berkley Physiol. Behav. in press.
Cited by
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Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1810764 · Cited by 2,249
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Pathogenesis and pathophysiology of endometriosis
Burney, R. O., & Giudice, L. C. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.029 · Cited by 1,590
Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., & Zondervan, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.090 · Cited by 1,584
Metadata
- Authors
- Berkley, K. J., Rapkin, A. J., & Papka, R. E.
- Affiliations
- Florida State University (US)
- ORCID
- Rapkin, Andrea J.
- Venue
- Science
- Published
- 2005-06-10
- Volume
- 308
- Issue
- 5728
- Pages
- 1587-1589
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068756641
- Cited by
- 455
- References
- 20
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 21 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 16 · 2016: 21 · 2015: 26 · 2014: 20 · 2013: 23 · 2012: 28
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK063937)
- National Institute of Neurological Disorders and Stroke (R01-NS-11892, R01 NS22526, R01NS022526, R01NS011892)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, pelvic pain, chronic pain, estrogen sensitivity, ectopic endometrium, innervation, central nervous system neurons, pain mechanisms
- MeSH terms
- Animals, Central Nervous System, Endometriosis, Female, Humans, Gonadotropin-Releasing Hormone, Neural Pathways, Neurons, Neurons, Afferent, Pain, Spinal Cord, Sympathetic Nervous System, Rats
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