Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum
Abstract
Study objective To evaluate the presence of nerve fibers and histopathology of normal peritoneum and endometriosis-harboring peritoneum. Design Prospective, nonrandomized study (Canadian Task Force classification II-1). Setting University hospital. Materials Peritoneal specimen from 40 women with laparoscopic findings of endometriosis (24 confirmed histopathologically, group H, 16 diagnosed by laparoscopy, group L) and from 9 women with no endometriosis (controls). Intervention Histopathologic examination of peritoneal specimens with nerve fibers identified by immunocytochemistry staining with an antibody to neurofilament. Measurements and main results No differences in mean nerve score were seen among the three groups. Degrees of lymphocytic infiltration and mesothelial hyperplasia were higher in group H than in the other two groups (p <0.01 and <0.05, respectively). The degree of lymphocytic infiltration was significantly higher in group L than in the control group (p <0.05). There were no differences in all measurements between women in group H who experienced chronic pelvic pain and those who did not. Conclusion The presence of nerve fibers in peritoneum is not related to endometriosis. Endometriosis-harboring peritoneum contains more lymphocytic infiltration than normal peritoneum. (J Am Assoc Gynecol Laparosc 8(1):95-98, 2001)
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Pelvic pain does not correlate with nerve fibers in adhesions, peritoneum, or endometriomas.
“pelvic pain is not correlated with nerve fibers in adhesions, peritoneum or within endometriomas”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Tulandi et al., 2001
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Self-citation
- Authors
- Tulandi, T., Felemban, A., & Fong Chen, M.
- Affiliations
- Royal Victoria Hospital (CA)
- Corresponding author
- Tulandi, Togas
- ORCID
- Tulandi, Togas
- Venue
- The Journal of the American Association of Gynecologic Laparoscopists
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 8
- Issue
- 1
- Pages
- 95-98
- ISSN
- 1074-3804 (ISSN-L)
- OpenAlex
- W2026202486
- Cited by
- 60
- References
- 7
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 3 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 4
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of the American Association of Gynecologic Laparoscopists (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Rheumatology › Omental and Epiploic Conditions
- Keywords
- endometriosis, peritoneum, nerve fibers, neurofilaments, lymphocyte infiltration, mesothelial hyperplasia, chronic pelvic pain, neurogenic inflammation
- MeSH terms
- Adult, Endometriosis, Female, Humans, Immunohistochemistry, Nerve Fibers, Peritoneum, Prospective Studies
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