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Progress in Modeling of Protein Structures and Interactions.

Schueler-Furman, Ora, Wang, Chu, Bradley, Phil, Misura, Kira, Baker, David·2005·Science

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Abstract

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

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Authors: Schueler-Furman, O., Wang, C., Bradley, P., Misura, K., & Baker, D.
Affiliations: Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Howard Hughes Medical Institute (US)
Corresponding author: Baker, David
ORCID: Wang, Chu
Baker, David
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-10-28
Volume: 310
Issue: 5748
Pages: 638-642
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1112160
OpenAlex: W2147752484
Cited by: 294
References: 65
Citations by year: 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 16
FWCI: 3.31
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
Keywords: protein structure prediction, protein-protein interaction, interatomic interactions, genome interpretation
MeSH terms: Computer Simulation, Computing Methodologies, Models, Molecular, Protein Conformation

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Progress in Modeling of Protein Structures and Interactions.

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