The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Progress in Modeling of Protein Structures and Interactions.
Abstract
The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.
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“Only recently it has been realized that proteins are not random heteropolymers but their sequences are formed following a tentative design (for a review see [39], [40]).”
From Lethal mutants and truncated selection together solve a paradox of the origin of life (2011) · cites this paper as [40]
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“A 3D model of the first 115 aa of claudin-19 was constructed using ROSETTA de novo methods, with use of a structure library of protein fragments.(14) Quality of the model was checked by WHATCHECK(15) and Ramachandran plot analysis.”
Method
Metadata
- Authors
- Schueler-Furman, O., Wang, C., Bradley, P., Misura, K., & Baker, D.
- Affiliations
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
- Howard Hughes Medical Institute (US)
- Corresponding author
- Baker, David
- Venue
- Science
- Published
- 2005-10-28
- Volume
- 310
- Issue
- 5748
- Pages
- 638-642
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2147752484
- Cited by
- 294
- References
- 65
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 16
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Keywords
- protein structure prediction, protein-protein interaction, interatomic interactions, genome interpretation
- MeSH terms
- Computer Simulation, Computing Methodologies, Models, Molecular, Protein Conformation
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