Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,631

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Genome of the African Trypanosome Trypanosoma brucei

Berriman, Matthew, Ghedin, Elodie, Hertz-Fowler, Christiane, Blandin, Gaëlle, Renauld, Hubert, Bartholomeu, Daniella C., Lennard, Nicola J., Caler, Elisabet, Hamlin, Nancy E., Haas, Brian, Böhme, Ulrike, Hannick, Linda, Aslett, Martin A., Shallom, Joshua, Marcello, Lucio, Hou, Lihua, Wickstead, Bill, Alsmark, U. Cecilia M., Arrowsmith, Claire, Atkin, Rebecca J., Barron, Andrew J., Bringaud, Frederic, Brooks, Karen, Carrington, Mark, Cherevach, Inna, Chillingworth, Tracey-Jane, Churcher, Carol, Clark, Louise N., Corton, Craig H., Cronin, Ann, Davies, Rob M., Doggett, Jonathon, Djikeng, Appolinaire, Feldblyum, Tamara, Field, Mark C., Fraser, Audrey, Goodhead, Ian, Hance, Zahra, Harper, David, Harris, Barbara R., Hauser, Heidi, Hostetler, Jessica, Ivens, Al, Jagels, Kay, Johnson, David, Johnson, Justin, Jones, Kristine, Kerhornou, Arnaud X., Koo, Hean, Larke, Natasha, Landfear, Scott, Larkin, Christopher, Leech, Vanessa, Line, Alexandra, Lord, Angela, MacLeod, Annette, Mooney, Paul J., Moule, Sharon, Martin, David M. A., Morgan, Gareth W., Mungall, Karen, Norbertczak, Halina, Ormond, Doug, Pai, Grace, Peacock, Chris S., Peterson, Jeremy, Quail, Michael A., Rabbinowitsch, Ester, Rajandream, Marie-Adele, Reitter, Chris, Salzberg, Steven L., Sanders, Mandy, Schobel, Seth, Sharp, Sarah, Simmonds, Mark, Simpson, Anjana J., Tallon, Luke, Turner, C. Michael R., Tait, Andrew, Tivey, Adrian R., Van Aken, Susan, Walker, Danielle, Wanless, David, Wang, Shiliang, White, Brian, White, Owen, Whitehead, Sally, Woodward, John, Wortman, Jennifer, Adams, Mark D., Embley, T. Martin, Gull, Keith, Ullu, Elisabetta, Barry, J. David, Fairlamb, Alan H., Opperdoes, Fred, Barrell, Barclay G., Donelson, John E., Hall, Neil, Fraser, Claire M., Melville, Sara E., El-Sayed, Najib M.·2005·Science
DOI 10.1126/science.1112642
Open this paper in CoChat — free account

Abstract

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei . The 26-megabase genome contains 9068 predicted genes, including ∼900 pseudogenes and ∼1700 T. brucei –specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi , and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major . Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1112642

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 53

  1. 10.1101/gr.2227704 · DOI
  2. 10.1016/S0166-6851(98)00054-1 · doi:10.1016/s0166-6851(98)00054-1
  3. 10.1128/EC.1.1.137-151.2002 · DOI
  4. 10.1093/nar/gkg674 · doi:10.1093/nar/gkg674
  5. 10.1093/nar/gkg673 · doi:10.1093/nar/gkg673
  6. 10.1126/science.1112680 · DOI · Paper page
  7. 10.1126/science.1112181 · DOI · Paper page
  8. 10.1016/S0092-8674(02)00711-0 · DOI · Paper page
  9. 10.1016/j.mib.2004.05.001 · DOI
  10. 10.1093/nar/10.19.5905 · DOI · Paper page
  11. 10.1017/S0031182000061035 · DOI
  12. 10.1016/S0022-2836(83)80034-5 · DOI
  13. A. Craig, A. Scherf, Eds., Antigenic Variation (Academic Press, Amsterdam, 2003), pp. 464.
  14. 10.1073/pnas.86.23.9375 · DOI
  15. 10.1016/0166-6851(92)90004-4 · doi:10.1016/0166-6851(92)90004-4
  16. 10.1073/pnas.231494798 · DOI
  17. 10.1016/S0020-7519(02)00247-3 · DOI
  18. 10.1016/0022-2836(91)80178-W · DOI
  19. 10.1038/nature01461 · DOI · Paper page
  20. 10.1038/nature01097 · DOI · Paper page
  21. 10.1101/gr.2955304 · DOI
  22. 10.1111/j.1365-2958.2004.04224.x · DOI
  23. 10.1111/j.1600-0854.2004.00234.x · DOI
  24. 10.1016/j.molbiopara.2005.01.017 · doi:10.1016/j.molbiopara.2005.01.017
  25. 10.1242/jcs.01624 · doi:10.1242/jcs.01624
  26. 10.1007/s004120050402 · DOI
  27. 10.1242/jcs.01515 · DOI
  28. 10.1038/sj.emboj.7600094 · DOI
  29. 10.1126/science.1110289 · DOI · Paper page
  30. 10.1096/fasebj.6.13.1397837 · DOI
  31. 10.1074/jbc.M201759200 · DOI
  32. 10.1073/pnas.95.6.3036 · DOI
  33. 10.1016/S0925-4439(02)00086-8 · DOI
  34. 10.1073/pnas.97.20.10673 · DOI
  35. 10.1073/pnas.092669999 · DOI
  36. 10.1128/MCB.15.10.5508 · DOI
  37. 10.1111/j.1550-7408.1977.tb04771.x · doi:10.1111/j.1550-7408.1977.tb04771.x
  38. 10.2307/3284707 · doi:10.2307/3284707
  39. 10.1016/S0166-4328(03)00075-5 · doi:10.1016/s0166-4328(03)00075-5
  40. 10.1074/jbc.M006850200 · doi:10.1074/jbc.m006850200
  41. 10.1099/00221287-101-2-243 · DOI
  42. 10.1089/152308602753625906 · DOI
  43. 10.1074/jbc.M402042200 · DOI
  44. 10.1111/j.1550-7408.2002.tb00346.x · doi:10.1111/j.1550-7408.2002.tb00346.x
  45. 10.1016/j.pt.2003.09.002 · DOI · Paper page
  46. 10.1074/jbc.M405635200 · doi:10.1074/jbc.m405635200
  47. 10.1074/jbc.M306306200 · DOI
  48. 10.1006/expr.1998.4237 · doi:10.1006/expr.1998.4237
  49. 10.1016/j.freeradbiomed.2004.02.008 · doi:10.1016/j.freeradbiomed.2004.02.008
  50. 10.1073/pnas.0402918101 · doi:10.1073/pnas.0402918101
  51. 10.1074/jbc.M401240200 · doi:10.1074/jbc.m401240200
  52. 10.1128/EC.3.2.245-254.2004 · doi:10.1128/ec.3.2.245-254.2004
  53. 10.1016/j.pt.2003.09.001 · DOI · Paper page

Cited by

See all 1,631

Metadata

Authors
Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E., Hamlin, N. E., Haas, B., Böhme, U., Hannick, L., Aslett, M. A., Shallom, J., Marcello, L., Hou, L., Wickstead, B., Alsmark, U. C. M., Arrowsmith, C., Atkin, R. J., Barron, A. J., Bringaud, F., Brooks, K., Carrington, M., Cherevach, I., Chillingworth, T.-J., Churcher, C., Clark, L. N., Corton, C. H., Cronin, A., Davies, R. M., Doggett, J., Djikeng, A., Feldblyum, T., Field, M. C., Fraser, A., Goodhead, I., Hance, Z., Harper, D., Harris, B. R., Hauser, H., Hostetler, J., Ivens, A., Jagels, K., Johnson, D., Johnson, J., Jones, K., Kerhornou, A. X., Koo, H., Larke, N., Landfear, S., Larkin, C., Leech, V., Line, A., Lord, A., MacLeod, A., Mooney, P. J., Moule, S., Martin, D. M. A., Morgan, G. W., Mungall, K., Norbertczak, H., Ormond, D., Pai, G., Peacock, C. S., Peterson, J., Quail, M. A., Rabbinowitsch, E., Rajandream, M.-A., Reitter, C., Salzberg, S. L., Sanders, M., Schobel, S., Sharp, S., Simmonds, M., Simpson, A. J., Tallon, L., Turner, C. M. R., Tait, A., Tivey, A. R., Van Aken, S., Walker, D., Wanless, D., Wang, S., White, B., White, O., Whitehead, S., Woodward, J., Wortman, J., Adams, M. D., Embley, T. M., Gull, K., Ullu, E., Barry, J. D., Fairlamb, A. H., Opperdoes, F., Barrell, B. G., Donelson, J. E., Hall, N., Fraser, C. M., Melville, S. E., & El-Sayed, N. M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2005-07-15
Volume
309
Issue
5733
Pages
416-422
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1112642
OpenAlex
W2111565312
Cited by
1,631
References
1
FWCI
78.31
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Genome of the African Trypanosome Trypanosoma brucei. https://app.cochat.ai/papers/10.1126/science.1112642
The paper
Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E., Hamlin, N. E., Haas, B., Böhme, U., Hannick, L., Aslett, M. A., Shallom, J., Marcello, L., Hou, L., Wickstead, B., Alsmark, U. C. M., Arrowsmith, C., . . . El-Sayed, N. M. (2005). The Genome of the African Trypanosome Trypanosoma brucei. Science. https://doi.org/10.1126/science.1112642

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.