The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Elucidation of the Small RNA Component of the Transcriptome
Abstract
Small RNAs play important regulatory roles in most eukaryotes, but only a small proportion of these molecules have been identified. We sequenced more than two million small RNAs from seedlings and the inflorescence of the model plant Arabidopsis thaliana . Known and new microRNAs (miRNAs) were among the most abundant of the nonredundant set of more than 75,000 sequences, whereas more than half represented lower abundance small interfering RNAs (siRNAs) that match repetitive sequences, intergenic regions, and genes. Individual or clusters of highly regulated small RNAs were readily observed. Targets of antisense RNA or miRNA did not appear to be preferentially associated with siRNAs. Many genomic regions previously considered featureless were found to be sites of numerous small RNAs.
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Cites
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays.
Brenner, S., Johnson, M., Bridgham, J., Golda, G., Lloyd, D. H., Johnson, D., Luo, S., McCurdy, S., Foy, M., Ewan, M., et al. (2000) · Nature Biotechnology · doi:10.1038/76469 · Cited by 1,360
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547
Mao, Y.-B., Cai, W.-J., Wang, J.-W., Hong, G.-J., Tao, X.-Y., Wang, L.-J., Huang, Y.-P., & Chen, X.-Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1352 · Cited by 1,358
Regulation of Phosphate Homeostasis by MicroRNA in Arabidopsis
Chiou, T.-J., Aung, K., Lin, S.-I., Wu, C.-C., Chiang, S.-F., & Su, C.-L. (2006) · The Plant Cell · doi:10.1105/tpc.105.038943 · Cited by 873
Metadata
- Authors
- Lu, C., Tej, S. S., Luo, S., Haudenschild, C. D., Meyers, B. C., & Green, P. J.
- Venue
- Science
- Published
- 2005-09-02
- Volume
- 309
- Issue
- 5740
- Pages
- 1567-1569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020878700
- Cited by
- 631
- References
- 1
- FWCI
- 82.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lu, C., Tej, S. S., Luo, S., Haudenschild, C. D., Meyers, B. C., & Green, P. J. (2005). Elucidation of the Small RNA Component of the Transcriptome. Science. https://doi.org/10.1126/science.1114112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
