The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage
Open accessAbstract
Oxidative stress and mutagenic DNA lesions formed by reactive oxygen species (ROS) are linked to human malignancy. Clinical treatments inducing chronic oxidative stress may therefore carry a risk of therapy-related cancer. We suggest that immunosuppression by azathioprine (Aza) may be one such treatment. Aza causes the accumulation of 6-thioguanine (6-TG) in patients' DNA. Here we demonstrate that biologically relevant doses of ultraviolet A (UVA) generate ROS in cultured cells with 6-TG–substituted DNA and that 6-TG and UVA are synergistically mutagenic. A replication-blocking DNA 6-TG photoproduct, guanine sulfonate, was bypassed by error-prone, Y-family DNA polymerases in vitro. A preliminary analysis revealed that in five of five cases, Aza treatment was associated with a selective UVA photosensitivity. These findings may partly explain the prevalence of skin cancer in long-term survivors of organ transplantation.
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Cites
Skin cancers after organ transplantation
Euvrard, S., Kanitakis, J., & Claudy, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022137 · Cited by 1,575
Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors
Al-Tassan, N., Chmiel, N. H., Maynard, J., Fleming, N., Livingston, A. L., Williams, G. T., Hodges, A. K., Davies, D. R., David, S. S., Sampson, J. R., et al. (2002) · Nature Genetics · doi:10.1038/ng828 · Cited by 1,394
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292
Self-citationRepair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753
Oxidative damage to DNA: formation, measurement and biochemical features
Cadet, J., Douki, T., Gasparutto, D., & Ravanat, J.-L. (2003) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2003.09.001 · Cited by 697
Lindelöf, B., Sigurgeirsson, B., Gäbel, H., & Stern, R. S. (2000) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2000.03703.x · Cited by 559
Non-melanoma skin cancer risk in the Queensland renal transplant population
Ramsay, H. M., Fryer, A. A., Hawley, C. M., Smith, A. G., Nicol, D. L., & Harden, P. N. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04976.x · Cited by 277
A role for ultraviolet A in solar mutagenesis.
Drobetsky, E. A., Turcotte, J., & Châteauneuf, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2350 · Cited by 256
Pharmacogenetics and cancer therapy
Relling, M. V., & Dervieux, T. (2001) · Nature Reviews Cancer · doi:10.1038/35101056 · Cited by 247
Mechanisms of tolerance to DNA damaging therapeutic drugs
Karran, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.12.1931 · Cited by 226
Self-citation
Cited by
Oxidative Stress in the Pathogenesis of Skin Disease
Bickers, D. R., & Athar, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700340 · Cited by 1,092
Cancers Complicating Inflammatory Bowel Disease
Beaugerie, L., & Itzkowitz, S. H. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1403718 · Cited by 678
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Di Mascio, P., Martinez, G. R., Miyamoto, S., Ronsein, G. E., Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 659
Karran, P., & Attard, N. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2292 · Cited by 477
Self-citationAxelrad, J. E., Lichtiger, S., & Yajnik, V. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i20.4794 · Cited by 431
Metadata
- Authors
- O'Donovan, P., Perrett, C. M., Zhang, X., Montaner, B., Xu, Y.-Z., Harwood, C. A., McGregor, J. M., Walker, S. L., Hanaoka, F., & Karran, P.
- Venue
- Science
- Published
- 2005-09-16
- Volume
- 309
- Issue
- 5742
- Pages
- 1871-1874
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2119665774
- Cited by
- 631
- References
- 23
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
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- O'Donovan, P., Perrett, C. M., Zhang, X., Montaner, B., Xu, Y.-Z., Harwood, C. A., McGregor, J. M., Walker, S. L., Hanaoka, F., & Karran, P. (2005). Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage. Science. https://doi.org/10.1126/science.1114233
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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