The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tissue-Specific TAFs Counteract Polycomb to Turn on Terminal Differentiation
Abstract
Polycomb transcriptional silencing machinery is implicated in the maintenance of precursor fates, but how this repression is reversed to allow cell differentiation is unknown. Here we show that testis-specific TAF (TBP-associated factor) homologs required for terminal differentiation of male germ cells may activate target gene expression in part by counteracting repression by Polycomb . Chromatin immunoprecipitation revealed that testis TAFs bind to target promoters, reduce Polycomb binding, and promote local accumulation of H3K4me3, a mark of Trithorax action. Testis TAFs also promoted relocalization of Polycomb Repression Complex 1 components to the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal differentiation.
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Cites
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Cited by
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,257
Polycomb silencing mechanisms and the management of genomic programmes
Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523
Polycomb/Trithorax response elements and epigenetic memory of cell identity
Ringrose, L., & Paro, R. (2007) · Development · doi:10.1242/dev.02723 · Cited by 444
Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
Zabidi, M. A., & Stark, A. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.10.003 · Cited by 228
Metadata
- Authors
- Chen, X., Hiller, M., Sancak, Y., & Fuller, M. T.
- Venue
- Science
- Published
- 2005-11-04
- Volume
- 310
- Issue
- 5749
- Pages
- 869-872
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986626974
- Cited by
- 175
- References
- 2
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, X., Hiller, M., Sancak, Y., & Fuller, M. T. (2005). Tissue-Specific TAFs Counteract Polycomb to Turn on Terminal Differentiation. Science. https://doi.org/10.1126/science.1118101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
