The DOI matches its Crossref record.
Structure of a V3-Containing HIV-1 gp120 Core
Open accessAbstract
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
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Cited by
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J.-P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K., et al. (2011) · Nature · doi:10.1038/nature10696 · Cited by 830
Self-citationWilen, C. B., Tilton, J. C., & Doms, R. W. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006866 · Cited by 654
Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., & Ray, B. (2009) · Glycobiology · doi:10.1093/glycob/cwn092 · Cited by 391
HIV entry and envelope glycoprotein-mediated fusion
Blumenthal, R., Durell, S., & Viard, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.406272 · Cited by 212
Wang, W., Nie, J., Prochnow, C., Truong, C., Jia, Z., Wang, S., Chen, X. S., & Wang, Y. (2013) · Retrovirology · doi:10.1186/1742-4690-10-14 · Cited by 114
Metadata
- Authors
- Huang, C.-C., Tang, M., Zhang, M.-Y., Majeed, S., Montabana, E., Stanfield, R. L., Dimitrov, D. S., Korber, B., Sodroski, J., Wilson, I. A., Wyatt, R., & Kwong, P. D.
- Venue
- Science
- Published
- 2005-11-11
- Volume
- 310
- Issue
- 5750
- Pages
- 1025-1028
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099308199
- Cited by
- 731
- References
- 0
- FWCI
- 16.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, C.-C., Tang, M., Zhang, M.-Y., Majeed, S., Montabana, E., Stanfield, R. L., Dimitrov, D. S., Korber, B., Sodroski, J., Wilson, I. A., Wyatt, R., & Kwong, P. D. (2005). Structure of a V3-Containing HIV-1 gp120 Core. Science. https://doi.org/10.1126/science.1118398
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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