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A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel
Abstract
Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium potentials for protons. The currents exhibited pH-dependent gating and zinc ion sensitivity, two features which are characteristic of voltage-gated proton channels. Responses of voltage dependence to sequence changes suggest that mouse voltage-sensor domain–only protein is itself a channel, rather than a regulator of another channel protein.
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Cited by
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Vermot, A., Petit-Härtlein, I., Smith, S. M. E., & Fieschi, F. (2021) · Antioxidants · doi:10.3390/antiox10060890 · Cited by 766
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Fisher, A. B. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2378 · Cited by 269
Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
Hu, M., Li, P., Wang, C., Feng, X., Geng, Q., Chen, W., Marthi, M., Zhang, W., Gao, C., Reid, W., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.021 · Cited by 254
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke
Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3059 · Cited by 252
Metadata
- Authors
- Sasaki, M., Takagi, M., & Okamura, Y.
- Venue
- Science
- Published
- 2006-04-28
- Volume
- 312
- Issue
- 5773
- Pages
- 589-592
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965191256
- Cited by
- 542
- References
- 0
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sasaki, M., Takagi, M., & Okamura, Y. (2006). A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel. Science. https://doi.org/10.1126/science.1122352
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
