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A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel
Abstract
Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium potentials for protons. The currents exhibited pH-dependent gating and zinc ion sensitivity, two features which are characteristic of voltage-gated proton channels. Responses of voltage dependence to sequence changes suggest that mouse voltage-sensor domain–only protein is itself a channel, rather than a regulator of another channel protein.
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Metadata
- Authors
- Sasaki, M., Takagi, M., & Okamura, Y.
- Venue
- Science
- Published
- 2006-04-28
- Volume
- 312
- Issue
- 5773
- Pages
- 589-592
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965191256
- Cited by
- 542
- References
- 0
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
