Redox signaling across cell membranes
Open accessAbstract
Generation of reactive oxygen species (ROS) by plasma membrane-localized NADPH oxidase (Nox 2) is a major mechanism of cell signaling associated with activation of the enzyme by a variety of agonists. With activation, the integral membrane flavocytochrome of Nox 2 transfers an electron from intracellular NADPH to extracellular O(2), generating superoxide anion (O(2)(*-)). The latter dismutes to H(2)O(2) which can diffuse through aquaporin channels in the plasma membrane to elicit an intracellular signaling response. O(2)(*-) also can initiate intracellular signaling by penetration of the cell membrane through anion channels (Cl(-) channel-3, ClC-3). Endosomes containing Nox2 and ClC-3 (called signaling endosomes) are composed of internalized plasma membrane and generate O(2)(*-) in the endosomal lumen to initiate signaling at intracellular sites. Thus, cellular signaling by Nox2 is dependent on the transmembrane flux of ROS. The role of this pathway has only recently been described and will require additional investigation to appreciate its physiological significance fully.
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ROS are generated on the membranes of the endosome of phagocytosing cells, with the involvement of NOx.
“ROS are generated on the membranes of the endosome of the phagocytosing cells, with the involvement of NOx [9].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [9]
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- Authors
- Fisher, A. B.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Fisher, Aron B.
- ORCID
- Fisher, Aron B.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-06
- Volume
- 11
- Issue
- 6
- Pages
- 1349-1356
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC2842114
- OpenAlex
- W2049637089
- Cited by
- 269
- References
- 62
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 16 · 2020: 23 · 2019: 22 · 2018: 23 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 15 · 2013: 13 · 2012: 5
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- NADPH oxidase 2, reactive oxygen species, superoxide, hydrogen peroxide, aquaporins, ClC-3 chloride channel, signaling endosomes, redox signaling, plasma membrane, flavocytochrome
- MeSH terms
- Animals, Cell Membrane, Humans, Models, Biological, Oxidation-Reduction, Superoxides, Signal Transduction, Reactive Oxygen Species
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