The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
MOSFET-Embedded Microcantilevers for Measuring Deflection in Biomolecular Sensors
Abstract
A promising approach for detecting biomolecules follows their binding to immobilized probe molecules on microfabricated cantilevers; binding causes surface stresses that bend the cantilever. We measured this deflection, which is on the order of tens of nanometers, by embedding a metal-oxide semiconductor field-effect transistor (MOSFET) into the base of the cantilever and recording decreases in drain current with deflections as small as 5 nanometers. The gate region of the MOSFET responds to surface stresses and thus is embedded in silicon nitride so as to avoid direct contact with the sample solution. This approach, which offers low noise, high sensitivity, and direct readout, was used to detect specific binding events with biotin and antibodies.
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Translating Biomolecular Recognition into Nanomechanics
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Cantilever transducers as a platform for chemical and biological sensors
Lavrik, N. V., Sepaniak, M. J., & Datskos, P. G. (2004) · Review of Scientific Instruments · doi:10.1063/1.1763252 · Cited by 1,117
Bioassay of prostate-specific antigen (PSA) using microcantilevers
Wu, G., Datar, R. H., Hansen, K. M., Thundat, T., Cote, R. J., & Majumdar, A. (2001) · Nature Biotechnology · doi:10.1038/nbt0901-856 · Cited by 1,013
Micromechanical cantilever-based biosensors
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Origin of nanomechanical cantilever motion generated from biomolecular interactions
Wu, G., Ji, H., Hansen, K., Thundat, T., Datar, R., Cote, R., Hagan, M. F., Chakraborty, A. K., & Majumdar, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1560 · Cited by 415
Environmental sensors based on micromachined cantilevers with integrated read-out
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A 2-D Microcantilever Array for Multiplexed Biomolecular Analysis
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Biosensor based on force microscope technology
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An integrated digital silicon micro-accelerometer with MOSFET-type sensing elements
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Cited by
Micro- and nanomechanical sensors for environmental, chemical, and biological detection
Waggoner, P. S., & Craighead, H. G. (2007) · Lab on a Chip · doi:10.1039/b707401h · Cited by 678
A dielectric-modulated field-effect transistor for biosensing
Im, H., Huang, X.-J., Gu, B., & Choi, Y.-K. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.180 · Cited by 635
Dielectric modulated junctionless biotube FET (DM-JL-BT-FET) Bio-Sensor
Goel, A., Rewari, S., Verma, S., Deswal, S. S., & Gupta, R. S. (2021) · IEEE Sensors Journal · doi:10.1109/jsen.2021.3077540 · Cited by 69
Metadata
- Authors
- Shekhawat, G., Tark, S.-H., & Dravid, V. P.
- Venue
- Science
- Published
- 2006-03-17
- Volume
- 311
- Issue
- 5767
- Pages
- 1592-1595
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089135572
- Cited by
- 286
- References
- 9
- FWCI
- 28.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shekhawat, G., Tark, S.-H., & Dravid, V. P. (2006). MOSFET-Embedded Microcantilevers for Measuring Deflection in Biomolecular Sensors. Science. https://doi.org/10.1126/science.1122588
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
