The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Translating Biomolecular Recognition into Nanomechanics
Abstract
We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable. Similar experiments on protein A–immunoglobulin interactions demonstrate the wide-ranging applicability of nanomechanical transduction to detect biomolecular recognition.
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Cites
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Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
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Systems Biology and New Technologies Enable Predictive and Preventative Medicine
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Single-Molecule Optomechanical Cycle
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Metadata
- Authors
- Fritz, J., Baller, M. K., Lang, H. P., Rothuizen, H., Vettiger, P., Meyer, E., -J. Güntherodt, H., Gerber, C., & Gimzewski, J. K.
- Venue
- Science
- Published
- 2000-04-14
- Volume
- 288
- Issue
- 5464
- Pages
- 316-318
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030552522
- Cited by
- 1,646
- References
- 12
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fritz, J., Baller, M. K., Lang, H. P., Rothuizen, H., Vettiger, P., Meyer, E., -J. Güntherodt, H., Gerber, C., & Gimzewski, J. K. (2000). Translating Biomolecular Recognition into Nanomechanics. Science. https://doi.org/10.1126/science.288.5464.316
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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