The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1
Abstract
The AUX1 and PIN auxin influx and efflux facilitators are key regulators of root growth and development. For root gravitropism to occur, AUX1 and PIN2 must transport auxin via the lateral root cap to elongating epidermal cells. Genetic studies suggest that AXR4 functions in the same pathway as AUX1. Here we show that AXR4 is a previously unidentified accessory protein of the endoplasmic reticulum (ER) that regulates localization of AUX1 but not of PIN proteins. Loss of AXR4 resulted in abnormal accumulation of AUX1 in the ER of epidermal cells, indicating that the axr4 agravitropic phenotype is caused by defective AUX1 trafficking in the root epidermis.
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Citations
Cites
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
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Cited by
Péret, B., Swarup, K., Ferguson, A., Seth, M., Yang, Y., Dhondt, S., James, N., Casimiro, I., Perry, P., Syed, A., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.097766 · Cited by 420
Self-citationAuxin Transporters--Why So Many?
Zazimalova, E., Murphy, A. S., Yang, H., Hoyerova, K., & Hosek, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001552 · Cited by 400
Molecular and cellular aspects of auxin-transport-mediated development
Vieten, A., Sauer, M., Brewer, P. B., & Friml, J. (2007) · Trends in Plant Science · doi:10.1016/j.tplants.2007.03.006 · Cited by 349
Vandenbussche, F., Petrášek, J., Žádníková, P., Hoyerová, K., Pešek, B., Raz, V., Swarup, R., Bennett, M., Zažímalová, E., Benková, E., et al. (2010) · Development · doi:10.1242/dev.040790 · Cited by 272
Self-citationCell Polarity Signaling in Arabidopsis
Yang, Z. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123233 · Cited by 269
Metadata
- Authors
- Dharmasiri, S., Swarup, R., Mockaitis, K., Dharmasiri, N., Singh, S. K., Kowalchyk, M., Marchant, A., Mills, S., Sandberg, G., Bennett, M. J., & Estelle, M.
- Venue
- Science
- Published
- 2006-05-26
- Volume
- 312
- Issue
- 5777
- Pages
- 1218-1220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2117260419
- Cited by
- 170
- References
- 1
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1. https://app.cochat.ai/papers/10.1126/science.1122847
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- Dharmasiri, S., Swarup, R., Mockaitis, K., Dharmasiri, N., Singh, S. K., Kowalchyk, M., Marchant, A., Mills, S., Sandberg, G., Bennett, M. J., & Estelle, M. (2006). AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1. Science. https://doi.org/10.1126/science.1122847
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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