The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
AUX/LAX Genes Encode a Family of Auxin Influx Transporters That Perform Distinct Functions during Arabidopsis Development
Open accessAbstract
Auxin transport, which is mediated by specialized influx and efflux carriers, plays a major role in many aspects of plant growth and development. AUXIN1 (AUX1) has been demonstrated to encode a high-affinity auxin influx carrier. In Arabidopsis thaliana, AUX1 belongs to a small multigene family comprising four highly conserved genes (i.e., AUX1 and LIKE AUX1 [LAX] genes LAX1, LAX2, and LAX3). We report that all four members of this AUX/LAX family display auxin uptake functions. Despite the conservation of their biochemical function, AUX1, LAX1, and LAX3 have been described to regulate distinct auxin-dependent developmental processes. Here, we report that LAX2 regulates vascular patterning in cotyledons. We also describe how regulatory and coding sequences of AUX/LAX genes have undergone subfunctionalization based on their distinct patterns of spatial expression and the inability of LAX sequences to rescue aux1 mutant phenotypes, respectively. Despite their high sequence similarity at the protein level, transgenic studies reveal that LAX proteins are not correctly targeted in the AUX1 expression domain. Domain swapping studies suggest that the N-terminal half of AUX1 is essential for correct LAX localization. We conclude that Arabidopsis AUX/LAX genes encode a family of auxin influx transporters that perform distinct developmental functions and have evolved distinct regulatory mechanisms.
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Cites
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
Self-citationAuxin: A Trigger for Change in Plant Development
Vanneste, S., & Friml, J. (2009) · Cell · doi:10.1016/j.cell.2009.03.001 · Cited by 1,302
Arabidopsis AUX1 Gene: A Permease-Like Regulator of Root Gravitropism
Bennett, M. J., Marchant, A., Green, H. G., May, S. T., Ward, S. P., Millner, P. A., Walker, A. R., Schulz, B., & Feldmann, K. A. (1996) · Science · doi:10.1126/science.273.5277.948 · Cited by 1,052
Self-citationPIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux
Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., et al. (2006) · Science · doi:10.1126/science.1123542 · Cited by 921
Self-citationPolar PIN Localization Directs Auxin Flow in Plants
Wiśniewska, J., Xu, J., Seifertová, D., Brewer, P. B., Růžička, K., Blilou, I., Rouquié, D., Benková, E., Scheres, B., & Friml, J. (2006) · Science · doi:10.1126/science.1121356 · Cited by 882
Auxin transport routes in plant development
Petrášek, J., & Friml, J. (2009) · Development · doi:10.1242/dev.030353 · Cited by 826
The auxin influx carrier LAX3 promotes lateral root emergence
Swarup, K., Benková, E., Swarup, R., Casimiro, I., Péret, B., Yang, Y., Parry, G., Nielsen, E., De Smet, I., Vanneste, S., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1754 · Cited by 817
Self-citationSwarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., & Bennett, M. (2001) · Genes & Development · doi:10.1101/gad.210501 · Cited by 645
Self-citationVieten, A., Vanneste, S., Wiśniewska, J., Benková, E., Benjamins, R., Beeckman, T., Luschnig, C., & Friml, J. (2005) · Development · doi:10.1242/dev.02027 · Cited by 636
Swarup, R., Kramer, E. M., Perry, P., Knox, K., Leyser, H. M. O., Haseloff, J., Beemster, G. T. S., Bhalerao, R., & Bennett, M. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1316 · Cited by 614
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Cited by
Auxin activity: Past, present, and future
Enders, T. A., & Strader, L. C. (2015) · American Journal of Botany · doi:10.3732/ajb.1400285 · Cited by 355
AUX/LAX family of auxin influx carriers—an overview
Swarup, R., & Péret, B. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00225 · Cited by 306
Self-citationPhototropism: Growing towards an Understanding of Plant Movement
Liscum, E., Askinosie, S. K., Leuchtman, D. L., Morrow, J., Willenburg, K. T., & Coats, D. R. (2014) · The Plant Cell · doi:10.1105/tpc.113.119727 · Cited by 215
Petersen, R., & Krost, C. (2013) · Planta · doi:10.1007/s00425-013-1898-9 · Cited by 61
Wong, A. C. S., van Oosterom, E. J., Godwin, I. D., & Borrell, A. K. (2023) · AoB Plants · doi:10.1093/aobpla/plad040 · Cited by 5
Metadata
- Authors
- Péret, B., Swarup, K., Ferguson, A., Seth, M., Yang, Y., Dhondt, S., James, N., Casimiro, I., Perry, P., Syed, A., Yang, H., Reemmer, J., Venison, E., Howells, C., Perez-Amador, M. A., Yun, J., Alonso, J., Beemster, G. T. S., Laplaze, L., Murphy, A., Bennett, M. J., Nielsen, E., & Swarup, R.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07
- Volume
- 24
- Issue
- 7
- Pages
- 2874-2885
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2159581229
- Cited by
- 420
- References
- 30
- FWCI
- 33.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Péret, B., Swarup, K., Ferguson, A., Seth, M., Yang, Y., Dhondt, S., James, N., Casimiro, I., Perry, P., Syed, A., Yang, H., Reemmer, J., Venison, E., Howells, C., Perez-Amador, M. A., Yun, J., Alonso, J., Beemster, G. T. S., Laplaze, L., . . . Swarup, R. (2012). AUX/LAX Genes Encode a Family of Auxin Influx Transporters That Perform Distinct Functions during Arabidopsis Development. The Plant Cell. https://doi.org/10.1105/tpc.112.097766
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
