The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Metagenomics to Paleogenomics: Large-Scale Sequencing of Mammoth DNA
Abstract
We sequenced 28 million base pairs of DNA in a metagenomics approach, using a woolly mammoth (Mammuthus primigenius) sample from Siberia. As a result of exceptional sample preservation and the use of a recently developed emulsion polymerase chain reaction and pyrosequencing technique, 13 million base pairs (45.4%) of the sequencing reads were identified as mammoth DNA. Sequence identity between our data and African elephant (Loxodonta africana) was 98.55%, consistent with a paleontologically based divergence date of 5 to 6 million years. The sample includes a surprisingly small diversity of environmental DNAs. The high percentage of endogenous DNA recoverable from this single mammoth would allow for completion of its genome, unleashing the field of paleogenomics.
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Self-citationNext-Generation DNA Sequencing Methods
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Genetic history of an archaic hominin group from Denisova Cave in Siberia
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Metadata
- Authors
- Poinar, H. N., Schwarz, C., Qi, J., Shapiro, B., MacPhee, R. D. E., Buigues, B., Tikhonov, A., Huson, D. H., Tomsho, L. P., Auch, A., Rampp, M., Miller, W., & Schuster, S. C.
- Venue
- Science
- Published
- 2006-01-20
- Volume
- 311
- Issue
- 5759
- Pages
- 392-394
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148994713
- Cited by
- 616
- References
- 24
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Poinar, H. N., Schwarz, C., Qi, J., Shapiro, B., MacPhee, R. D. E., Buigues, B., Tikhonov, A., Huson, D. H., Tomsho, L. P., Auch, A., Rampp, M., Miller, W., & Schuster, S. C. (2006). Metagenomics to Paleogenomics: Large-Scale Sequencing of Mammoth DNA. Science. https://doi.org/10.1126/science.1123360
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