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Phase Modifiers Promote Efficient Production of Hydroxymethylfurfural from Fructose
Abstract
Furan derivatives obtained from renewable biomass resources have the potential to serve as substitutes for the petroleum-based building blocks that are currently used in the production of plastics and fine chemicals. We developed a process for the selective dehydration of fructose to 5-hydroxymethylfurfural (HMF) that operates at high fructose concentrations (10 to 50 weight %), achieves high yields (80% HMF selectivity at 90% fructose conversion), and delivers HMF in a separation-friendly solvent. In a two-phase reactor system, fructose is dehydrated in the aqueous phase with the use of an acid catalyst (hydrochloric acid or an acidic ion-exchange resin) with dimethylsulfoxide and/or poly(1-vinyl-2-pyrrolidinone) added to suppress undesired side reactions. The HMF product is continuously extracted into an organic phase (methylisobutylketone) modified with 2-butanol to enhance partitioning from the reactive aqueous solution.
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Cited by
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
van Putten, R.-J., van der Waal, J. C., de Jong, E., Rasrendra, C. B., Heeres, H. J., & de Vries, J. G. (2013) · Chemical Reviews · doi:10.1021/cr300182k · Cited by 2,886
Catalytic conversion of biomass to biofuels
Alonso, D. M., Bond, J. Q., & Dumesic, J. A. (2010) · Green Chemistry · doi:10.1039/c004654j · Cited by 2,333
Self-citationMetal Chlorides in Ionic Liquid Solvents Convert Sugars to 5-Hydroxymethylfurfural
Zhao, H., Holladay, J. E., Brown, H., & Zhang, Z. C. (2007) · Science · doi:10.1126/science.1141199 · Cited by 1,997
Furfural—A Promising Platform for Lignocellulosic Biofuels
Lange, J., van der Heide, E., van Buijtenen, J., & Price, R. (2012) · ChemSusChem · doi:10.1002/cssc.201100648 · Cited by 1,323
Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes
Kunkes, E. L., Simonetti, D. A., West, R. M., Serrano-Ruiz, J. C., Gärtner, C. A., & Dumesic, J. A. (2008) · Science · doi:10.1126/science.1159210 · Cited by 895
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Metadata
- Authors
- Román-Leshkov, Y., Chheda, J. N., & Dumesic, J. A.
- Venue
- Science
- Published
- 2006-06-30
- Volume
- 312
- Issue
- 5782
- Pages
- 1933-1937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983683645
- Cited by
- 1,670
- References
- 0
- FWCI
- 22.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Román-Leshkov, Y., Chheda, J. N., & Dumesic, J. A. (2006). Phase Modifiers Promote Efficient Production of Hydroxymethylfurfural from Fructose. Science. https://doi.org/10.1126/science.1126337
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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