The DOI matches its Crossref record.
Phase Modifiers Promote Efficient Production of Hydroxymethylfurfural from Fructose
Abstract
Furan derivatives obtained from renewable biomass resources have the potential to serve as substitutes for the petroleum-based building blocks that are currently used in the production of plastics and fine chemicals. We developed a process for the selective dehydration of fructose to 5-hydroxymethylfurfural (HMF) that operates at high fructose concentrations (10 to 50 weight %), achieves high yields (80% HMF selectivity at 90% fructose conversion), and delivers HMF in a separation-friendly solvent. In a two-phase reactor system, fructose is dehydrated in the aqueous phase with the use of an acid catalyst (hydrochloric acid or an acidic ion-exchange resin) with dimethylsulfoxide and/or poly(1-vinyl-2-pyrrolidinone) added to suppress undesired side reactions. The HMF product is continuously extracted into an organic phase (methylisobutylketone) modified with 2-butanol to enhance partitioning from the reactive aqueous solution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
van Putten, R.-J., van der Waal, J. C., de Jong, E., Rasrendra, C. B., Heeres, H. J., & de Vries, J. G. (2013) · Chemical Reviews · doi:10.1021/cr300182k · Cited by 2,886
Catalytic conversion of biomass to biofuels
Alonso, D. M., Bond, J. Q., & Dumesic, J. A. (2010) · Green Chemistry · doi:10.1039/c004654j · Cited by 2,333
Self-citationMetal Chlorides in Ionic Liquid Solvents Convert Sugars to 5-Hydroxymethylfurfural
Zhao, H., Holladay, J. E., Brown, H., & Zhang, Z. C. (2007) · Science · doi:10.1126/science.1141199 · Cited by 1,997
Furfural—A Promising Platform for Lignocellulosic Biofuels
Lange, J., van der Heide, E., van Buijtenen, J., & Price, R. (2012) · ChemSusChem · doi:10.1002/cssc.201100648 · Cited by 1,323
Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes
Kunkes, E. L., Simonetti, D. A., West, R. M., Serrano-Ruiz, J. C., Gärtner, C. A., & Dumesic, J. A. (2008) · Science · doi:10.1126/science.1159210 · Cited by 895
Self-citationReplacing fossil based PET with biobased PEF; process analysis, energy and GHG balance
Eerhart, A. J. J. E., Faaij, A. P. C., & Patel, M. K. (2012) · Energy & Environmental Science · doi:10.1039/c2ee02480b · Cited by 666
Controlled Polymerization of Next-Generation Renewable Monomers and Beyond
Yao, K., & Tang, C. (2013) · Macromolecules · doi:10.1021/ma3019574 · Cited by 485
Buntara, T., Noel, S., Phua, P. H., Melián‐Cabrera, I., de Vries, J. G., & Heeres, H. J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102156 · Cited by 477
Carbon dioxide utilization via carbonate-promoted C–H carboxylation
Banerjee, A., Dick, G. R., Yoshino, T., & Kanan, M. W. (2016) · Nature · doi:10.1038/nature17185 · Cited by 431
Green Processing of Lignocellulosic Biomass and Its Derivatives in Deep Eutectic Solvents
Tang, X., Zuo, M., Li, Z., Liu, H., Xiong, C., Zeng, X., Sun, Y., Hu, L., Liu, S., Lei, T., et al. (2017) · ChemSusChem · doi:10.1002/cssc.201700457 · Cited by 380
Lignin depolymerization into aromatic monomers over solid acid catalysts
Deepa, A. K., & Dhepe, P. L. (2015) · ACS Catalysis · doi:10.1021/cs501371q · Cited by 346
Zhu, J., Cai, J., Xie, W., Chen, P.-H., Gazzano, M., Scandola, M., & Gross, R. A. (2013) · Macromolecules · doi:10.1021/ma3023298 · Cited by 333
Rinaldi, R., Meine, N., vom Stein, J., Palkovits, R., & Schüth, F. (2010) · ChemSusChem · doi:10.1002/cssc.200900281 · Cited by 201
Process integration for the conversion of glucose to 2, 5-furandicarboxylic acid
Boisen, A., Christensen, T. B., Fu, W., Gorbanev, Y. Y., Hansen, T. S., Jensen, J. S., Klitgaard, S. K., Pedersen, S., Riisager, A., Ståhlberg, T., et al. (2009) · Chemical Engineering Research and Design · doi:10.1016/j.cherd.2009.06.010 · Cited by 184
Zhang, J., Liu, X., Sun, M., Ma, X., & Han, Y. (2012) · ACS Catalysis · doi:10.1021/cs300342k · Cited by 156
Wet organic waste treatment via hydrothermal processing: A critical review
Marzbali, M. H., Kundu, S., Halder, P., Patel, S., Hakeem, I. G., Paz-Ferreiro, J., Madapusi, S., Surapaneni, A., & Shah, K. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130557 · Cited by 147
Organocatalysis in biorefining for biomass conversion and upgrading
Liu, D. (. J. )., & Chen, E. Y.-X. (2014) · Green Chem. · doi:10.1039/c3gc41934g · Cited by 101
Gao, T., An, Q., Tang, X., Yue, Q., Zhang, Y., Li, B., Li, P., & Jin, Z. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d4cp01680g · Cited by 35
Hydrogenolysis of Aromatic Oxygenates Over Pt/WO 3 –ZrO 2 in a Water/Decane Biphasic System
Ai, A., Ezoe, Y., Nogami, T., Miura, H., Shishido, T., Jin, X., & Nozaki, K. (2026) · ChemSusChem · doi:10.1002/cssc.71085
Metadata
- Authors
- Román-Leshkov, Y., Chheda, J. N., & Dumesic, J. A.
- Venue
- Science
- Published
- 2006-06-30
- Volume
- 312
- Issue
- 5782
- Pages
- 1933-1937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983683645
- Cited by
- 1,670
- References
- 0
- FWCI
- 22.91
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
