The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation
Abstract
Yersinia species use a variety of type III effector proteins to target eukaryotic signaling systems. The effector YopJ inhibits mitogen-activated protein kinase (MAPK) and the nuclear factor κB (NFκB) signaling pathways used in innate immune response by preventing activation of the family of MAPK kinases (MAPKK). We show that YopJ acted as an acetyltransferase, using acetyl–coenzyme A (CoA) to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation. The acetylation on MAPKK6 directly competed with phosphorylation, preventing activation of the modified protein. This covalent modification may be used as a general regulatory mechanism in biological signaling.
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Cites
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YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
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Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
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Self-citationInhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector
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Self-citationFunction of the Yersinia effector YopJ
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Self-citationThe Evolution of Flea-borne Transmission inYersinia pestis
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Functions of the Yersinia effector proteins in inhibiting host immune responses
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Cited by
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430
Yang, X.-J., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210599 · Cited by 940
Salmonellae interplay with host cells
Haraga, A., Ohlson, M. B., & Miller, S. I. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1788 · Cited by 832
Metadata
- Authors
- Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J., & Orth, K.
- Venue
- Science
- Published
- 2006-05-26
- Volume
- 312
- Issue
- 5777
- Pages
- 1211-1214
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972169896
- Cited by
- 615
- References
- 13
- FWCI
- 27.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J., & Orth, K. (2006). Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation. Science. https://doi.org/10.1126/science.1126867
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
