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Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
Abstract
Homologs of the Yersinia virulence effector YopJ are found in both plant and animal bacterial pathogens, as well as plant symbionts. These YopJ family members were shown to act as cysteine proteases. The catalytic triad of the protease was required for inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling in animal cells and for induction of localized cell death in plants. The substrates for YopJ were shown to be highly conserved ubiquitin-like molecules, which are covalently added to numerous regulatory proteins. YopJ family members exert their pathogenic effect on cells by disrupting this posttranslational modification.
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Citations
Cited by
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
The two NF-κB activation pathways and their role in innate and adaptive immunity
Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
Salmonella Interactions with Host Cells: Type III Secretion at Work
Galán, J. E. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.53 · Cited by 732
Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.009 · Cited by 616
Metadata
- Authors
- Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B., & Dixon, J. E.
- Venue
- Science
- Published
- 2000-11-24
- Volume
- 290
- Issue
- 5496
- Pages
- 1594-1597
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030598858
- Cited by
- 542
- References
- 0
- FWCI
- 59.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B., & Dixon, J. E. (2000). Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease. Science. https://doi.org/10.1126/science.290.5496.1594
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