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Structure of the Eukaryotic Thiamine Pyrophosphate Riboswitch with Its Regulatory Ligand
Open accessAbstract
Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom–resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)–specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel “sensor” helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.
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Cites
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550
Adenine riboswitches and gene activation by disruption of a transcription terminator
Mandal, M., & Breaker, R. R. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb710 · Cited by 514
Cited by
Serganov, A., & Nudler, E. (2013) · Cell · doi:10.1016/j.cell.2012.12.024 · Cited by 1,013
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
Famulok, M., Hartig, J. S., & Mayer, G. (2007) · Chemical Reviews · doi:10.1021/cr0306743 · Cited by 887
The Structural and Functional Diversity of Metabolite-Binding Riboswitches
Roth, A., & Breaker, R. R. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070507.135656 · Cited by 553
The distributions, mechanisms, and structures of metabolite-binding riboswitches
Barrick, J. E., & Breaker, R. R. (2007) · Genome Biology · doi:10.1186/gb-2007-8-11-r239 · Cited by 477
Riboswitches: Emerging Themes in RNA Structure and Function
Montange, R. K., & Batey, R. T. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.130000 · Cited by 386
Metadata
- Authors
- Thore, S., Leibundgut, M., & Ban, N.
- Venue
- Science
- Published
- 2006-05-26
- Volume
- 312
- Issue
- 5777
- Pages
- 1208-1211
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080911376
- Cited by
- 345
- References
- 2
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Thore, S., Leibundgut, M., & Ban, N. (2006). Structure of the Eukaryotic Thiamine Pyrophosphate Riboswitch with Its Regulatory Ligand. Science. https://doi.org/10.1126/science.1128451
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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