The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Riboswitches: Emerging Themes in RNA Structure and Function
Abstract
Riboswitches are RNAs capable of binding cellular metabolites using a diverse array of secondary and tertiary structures to modulate gene expression. The recent determination of the three-dimensional structures of parts of six different riboswitches illuminates common features that allow riboswitches to be grouped into one of two types. Type I riboswitches, as exemplified by the purine riboswitch, are characterized by a single, localized binding pocket supported by a largely pre-established global fold. This arrangement limits ligand-induced conformational changes in the RNA to a small region. In contrast, Type II riboswitches, such as the thiamine pyrophosphate riboswitch, contain binding pockets split into at least two spatially distinct sites. As a result, binding induces both local changes to the binding pocket and global architecture. Similar organizational themes are found in other noncoding RNAs, making it possible to begin to build a hierarchical classification of RNA structure based on the spatial organization of their active sites and associated secondary structural elements.
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Cites
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Control of gene expression by a natural metabolite-responsive ribozyme
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SCOP database in 2004: refinements integrate structure and sequence family data
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Genetic Control by a Metabolite Binding mRNA
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Crystal structure of a hepatitis delta virus ribozyme
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REGULATION OF BACTERIAL GENE EXPRESSION BY RIBOSWITCHES
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Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria
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Conformational selection or induced fit: A flux description of reaction mechanism
Hammes, G. G., Chang, Y.-C., & Oas, T. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907195106 · Cited by 577
The Structural and Functional Diversity of Metabolite-Binding Riboswitches
Roth, A., & Breaker, R. R. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070507.135656 · Cited by 553
Prospects for riboswitch discovery and analysis
Breaker, R. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.024 · Cited by 464
Metadata
- Authors
- Montange, R. K., & Batey, R. T.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2008-06-01
- Volume
- 37
- Issue
- 1
- Pages
- 117-133
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2106769579
- Cited by
- 386
- References
- 92
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
