The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
The Structural and Functional Diversity of Metabolite-Binding Riboswitches
Open accessAbstract
The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. Although proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression
Winkler, W., Nahvi, A., & Breaker, R. R. (2002) · Nature · doi:10.1038/nature01145 · Cited by 1,242
Self-citationInteraction of antibiotics with functional sites in 16S ribosomal RNA
Moazed, D., & Noller, H. F. (1987) · Nature · doi:10.1038/327389a0 · Cited by 1,150
Control of gene expression by a natural metabolite-responsive ribozyme
Winkler, W. C., Nahvi, A., Roth, A., Collins, J. A., & Breaker, R. R. (2004) · Nature · doi:10.1038/nature02362 · Cited by 951
Self-citationGenetic Control by a Metabolite Binding mRNA
Nahvi, A., Sudarsan, N., Ebert, M. S., Zou, X., Brown, K. L., & Breaker, R. R. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00224-7 · Cited by 801
Self-citationThe chemical repertoire of natural ribozymes
Doudna, J. A., & Cech, T. R. (2002) · Nature · doi:10.1038/418222a · Cited by 745
The kink-turn: a new RNA secondary structure motif
Klein, D. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4214 · Cited by 741
REGULATION OF BACTERIAL GENE EXPRESSION BY RIBOSWITCHES
Winkler, W. C., & Breaker, R. R. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121336 · Cited by 727
Self-citationRiboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria
Mandal, M., Boese, B., Barrick, J. E., Winkler, W. C., & Breaker, R. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00391-x · Cited by 726
Self-citation
Cited by
Riboswitches and the RNA World
Breaker, R. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003566 · Cited by 666
Self-citationProspects for riboswitch discovery and analysis
Breaker, R. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.024 · Cited by 464
Self-citationWeinberg, Z., Wang, J. X., Bogue, J., Yang, J., Corbino, K., Moy, R. H., & Breaker, R. R. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r31 · Cited by 354
Self-citationAn Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger
Lee, E. R., Baker, J. L., Weinberg, Z., Sudarsan, N., & Breaker, R. R. (2010) · Science · doi:10.1126/science.1190713 · Cited by 347
Self-citationAccurate SHAPE-directed RNA secondary structure modeling, including pseudoknots
Hajdin, C. E., Bellaousov, S., Huggins, W., Leonard, C. W., Mathews, D. H., & Weeks, K. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219988110 · Cited by 331
Metadata
- Authors
- Roth, A., & Breaker, R. R.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 305-334
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2157052506
- Cited by
- 553
- References
- 124
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Structural and Functional Diversity of Metabolite-Binding Riboswitches. https://app.cochat.ai/papers/10.1146/annurev.biochem.78.070507.135656
- The paper
- Roth, A., & Breaker, R. R. (2009). The Structural and Functional Diversity of Metabolite-Binding Riboswitches. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.78.070507.135656
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.