The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Receptor Activation Alters Inner Surface Potential During Phagocytosis
Abstract
The surface potential of biological membranes varies according to their lipid composition. We devised genetically encoded probes to assess surface potential in intact cells. These probes revealed marked, localized alterations in the charge of the inner surface of the plasma membrane of macrophages during the course of phagocytosis. Hydrolysis of phosphoinositides and displacement of phosphatidylserine accounted for the change in surface potential at the phagosomal cup. Signaling molecules such as K-Ras, Rac1, and c-Src that are targeted to the membrane by electrostatic interactions were rapidly released from membrane subdomains where the surface charge was altered by lipid remodeling during phagocytosis.
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“In addition to stage-specific v-, t-SNAREs and Rab proteins, phosphatidylinositide (PI) lipids synthesized by stage-specific phosphatidyl inositol kinases (PIK) at the cytoplasmic sheet of phagosomal membranes are specific for different phagosome stages and functionally contribute to maturation-associated vesicle fusion and actin-polymerization associated processes (16).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [16]
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Cites
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Differential Localization of Rho Gtpases in Live Cells
Michaelson, D., Silletti, J., Murphy, G., D'Eustachio, P., Rush, M., & Philips, M. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.1.111 · Cited by 679
Self-citationThe myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions
McLaughlin, S., & Aderem, A. A. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89042-8 · Cited by 674
Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis
Hoppe, A. D., & Swanson, J. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0847 · Cited by 365
Olivotto, M., Arcangeli, A., Carlà, M., & Wanke, E. (1996) · BioEssays · doi:10.1002/bies.950180612 · Cited by 127
McCabe, J. B., & Berthiaume, L. G. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3601 · Cited by 122
Roy, M., Leventis, R., & Silvius, J. R. (2000) · Biochemistry · doi:10.1021/bi000512q · Cited by 102
Self-citationLipid-Binding Characteristics of the Polybasic Carboxy-Terminal Sequence of K-ras4B
Leventis, R., & Silvius, J. R. (1998) · Biochemistry · doi:10.1021/bi973077h · Cited by 85
Self-citationPhosphoinositide Involvement in Phagocytosis and Phagosome Maturation
Botelho, R. J., Scott, C. C., & Grinstein, S. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18805-3_1 · Cited by 55
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Research works printed but not linked: 1
- R. J. Botelho, C. C. Scott, S. Grinstein, Curr. Top. Microbiol. Immunol.282, 1 (2004).
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
Yeung, T., Gilbert, G. E., Shi, J., Silvius, J. R., Kapùs, A., & Grinstein, S. (2008) · Science · doi:10.1126/science.1152066 · Cited by 1,109
Self-citationThe Cell Biology of Phagocytosis
Flannagan, R. S., Jaumouillé, V., & Grinstein, S. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132445 · Cited by 1,096
Self-citationMacrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Shaping cups into phagosomes and macropinosomes
Swanson, J. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2447 · Cited by 941
Metadata
- Authors
- Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S.
- Affiliations
- University of Toronto (CA)
- Division of Cell Biology, Hepatology, and Nutrition Department, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
- Corresponding author
- Grinstein, Sergio
- ORCID
- Venue
- Science
- Published
- 2006-07-21
- Volume
- 313
- Issue
- 5785
- Pages
- 347-351
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999972891
- Cited by
- 329
- References
- 9
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 16 · 2023: 15 · 2022: 10 · 2021: 15 · 2020: 17 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 17 · 2012: 22
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- membrane surface potential, phagocytosis, macrophages, plasma membrane, phosphoinositide hydrolysis, phosphatidylserine exposure, lipid remodeling, genetically encoded probes, KRAS, Rac1, Src kinase, lipid rafts, receptor activation
- MeSH terms
- Animals, Calcium, Cell Line, Cell Membrane, Fluorescent Dyes, Immunoglobulin G, Lipid Bilayers, Liposomes, Macrophages, Membrane Potentials, Neuropeptides, Opsonin Proteins, Peptides, Phagocytosis, Phagosomes, Phospholipids, Receptors, Fc, Molecular Probes, Ionomycin, ras Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein, Mice, Static Electricity, Hydrophobic and Hydrophilic Interactions
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