The DOI matches its Crossref record.
An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order
Abstract
CD8-positive T lymphocytes recognize peptides that are usually derived from the degradation of cellular proteins and are presented by class I molecules of the major histocompatibility complex. Here we describe a human minor histocompatibility antigen created by a polymorphism in the SP110 nuclear phosphoprotein gene. The antigenic peptide comprises two noncontiguous SP110 peptide segments spliced together in reverse order to that in which they occur in the predicted SP110 protein. The antigenic peptide could be produced in vitro by incubation of precursor peptides with highly purified 20 S proteasomes. Cutting and splicing probably occur within the proteasome by transpeptidation.
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Cited by
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Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., Armstrong, M., Powell, R. L., Reisdorph, N., Kumar, N., et al. (2016) · Science · doi:10.1126/science.aad2791 · Cited by 503
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The role of the proteasome in the generation of MHC class I ligands and immune responses
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Metadata
- Authors
- Warren, E. H., Vigneron, N. J., Gavin, M. A., Coulie, P. G., Stroobant, V., Dalet, A., Tykodi, S. S., Xuereb, S. M., Mito, J. K., Riddell, S. R., & Van den Eynde, B. J.
- Venue
- Science
- Published
- 2006-09-08
- Volume
- 313
- Issue
- 5792
- Pages
- 1444-1447
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2132972924
- Cited by
- 201
- References
- 0
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order. https://app.cochat.ai/papers/10.1126/science.1130660
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- Warren, E. H., Vigneron, N. J., Gavin, M. A., Coulie, P. G., Stroobant, V., Dalet, A., Tykodi, S. S., Xuereb, S. M., Mito, J. K., Riddell, S. R., & Van den Eynde, B. J. (2006). An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order. Science. https://doi.org/10.1126/science.1130660
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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