Cited by 449Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

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Leko, Vid, Rosenberg, Steven A.·2020·Cancer Cell

Abstract

Cancer elimination in humans can be achieved with immunotherapy that relies on T lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have been recognized based on their cellular origins and expression patterns, while their detection has been greatly facilitated by recent achievements in next-generation sequencing and immunopeptidomics. Some of them have been targeted in clinical trials with various immunotherapy approaches, while many others remain untested. Here, we discuss molecular identification of different tumor antigen types, and the clinical safety and efficacy of targeting them with immunotherapy. Additionally, we suggest strategies to increase the efficacy and availability of antigen-directed immunotherapies for treatment of patients with metastatic cancer.

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Crossref · 10.1016/j.ccell.2020.07.013

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  • Application of ACT in solid tumors encounters significant limitations and challenges, primarily stemming from the availability and quality of isolated immune cells.

    “However, the application of ACT in solid tumors encounters significant limitations and challenges, primarily stemming from the availability and quality of isolated immune cells.”

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Authors
Leko, V., & Rosenberg, S. A.
Affiliations
National Institutes of Health (US)
Corresponding author
  • Leko, Vid
  • Rosenberg, Steven A.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2020-10
Volume
38
Issue
4
Pages
454-472
ISSN
1535-6108 (ISSN-L)
OpenAlex
W3052573234
Cited by
449
References
167
Citations by year
2026: 61 · 2025: 97 · 2024: 104 · 2023: 79 · 2022: 72 · 2021: 36
FWCI
4.56
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
tumor antigens, T cell-based immunotherapy, solid tumors, cancer immunotherapy, immunopeptidomics, antigen identification, metastatic cancer, treatment efficacy and safety
MeSH terms
Immune Checkpoint Inhibitors, Antigens, Neoplasm, Humans, Immunotherapy, Interleukin-2, Neoplasms, T-Lymphocytes, Immunotherapy, Adoptive, Models, Immunological, Oncolytic Virotherapy

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