The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Open accessAbstract
T cells target peptide combos: One of the enduring mysteries of autoimmunity is the identity of the specific proteins targeted by autoimmune T cells. Delong et al. used mass spectrometry to elucidate the peptide targets of autoimmune T cells isolated from a mouse model of type 1 diabetes. T cells targeted hybrid peptides formed by the covalent linking of a peptide derived from pro-insulin to other peptides derived from proteins found in pancreatic beta cells. T cells isolated from the pancreatic islets of two individuals with type 1 diabetes also recognized such hybrid peptides, suggesting that they may play an important role in driving disease. Science , this issue p. 711
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Cites
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Self-citationImmune recognition of a human renal cancer antigen through post-translational protein splicing
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The insulin A-chain epitope recognized by human T cells is posttranslationally modified
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Self-citationAn Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order
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Cited by
Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, Å. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.16 · Cited by 1,475
Dendrou, C. A., Petersen, J., Rossjohn, J., & Fugger, L. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.143 · Cited by 787
Environmental risk factors for type 1 diabetes
Rewers, M., & Ludvigsson, J. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30507-4 · Cited by 676
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
Roep, B. O., Thomaidou, S., van Tienhoven, R., & Zaldumbide, A. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00443-4 · Cited by 623
The multiple pathways to autoimmunity
Theofilopoulos, A. N., Kono, D. H., & Baccala, R. (2017) · Nature Immunology · doi:10.1038/ni.3731 · Cited by 590
Metadata
- Authors
- Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., Armstrong, M., Powell, R. L., Reisdorph, N., Kumar, N., Elso, C. M., DeNicola, M., Bottino, R., Powers, A. C., Harlan, D. M., Kent, S. C., Mannering, S. I., & Haskins, K.
- Venue
- Science
- Published
- 2016-02-12
- Volume
- 351
- Issue
- 6274
- Pages
- 711-714
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2266478788
- Cited by
- 503
- References
- 25
- FWCI
- 48.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., Armstrong, M., Powell, R. L., Reisdorph, N., Kumar, N., Elso, C. M., DeNicola, M., Bottino, R., Powers, A. C., Harlan, D. M., Kent, S. C., Mannering, S. I., & Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. https://doi.org/10.1126/science.aad2791
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