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Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching
Open accessAbstract
Using single-molecule DNA nanomanipulation, we show that abortive initiation involves DNA “scrunching”—in which RNA polymerase (RNAP) remains stationary and unwinds and pulls downstream DNA into itself—and that scrunching requires RNA synthesis and depends on RNA length. We show further that promoter escape involves scrunching, and that scrunching occurs in most or all instances of promoter escape. Our results support the existence of an obligatory stressed intermediate, with approximately one turn of additional DNA unwinding, in escape and are consistent with the proposal that stress in this intermediate provides the driving force to break RNAP-promoter and RNAP-initiation-factor interactions in escape.
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Cites
Predicting DNA duplex stability from the base sequence
Breslauer, K. J., Frank, R., Blöcker, H., & Marky, L. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3746 · Cited by 1,837
Cited by
High-Resolution, Single-Molecule Measurements of Biomolecular Motion
Greenleaf, W. J., Woodside, M. T., & Block, S. M. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.36.101106.101451 · Cited by 462
The Mediator complex and transcription regulation
Poss, Z. C., Ebmeier, C. C., & Taatjes, D. J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.840259 · Cited by 364
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
Haugen, S. P., Ross, W., & Gourse, R. L. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1912 · Cited by 320
Quantifying how DNA stretches, melts and changes twist under tension
Gross, P., Laurens, N., Oddershede, L. B., Bockelmann, U., Peterman, E. J. G., & Wuite, G. J. L. (2011) · Nature Physics · doi:10.1038/nphys2002 · Cited by 257
Revisiting the central dogma one molecule at a time
Bustamante, C., Cheng, W., & Mejia, Y. X. (2011) · Cell · doi:10.1016/j.cell.2011.01.033 · Cited by 173
Metadata
- Authors
- Revyakin, A., Liu, C., Ebright, R. H., & Strick, T. R.
- Venue
- Science
- Published
- 2006-11-17
- Volume
- 314
- Issue
- 5802
- Pages
- 1139-1143
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084744901
- Cited by
- 397
- References
- 1
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Revyakin, A., Liu, C., Ebright, R. H., & Strick, T. R. (2006). Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching. Science. https://doi.org/10.1126/science.1131398
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
