An Essential Role for LEDGF/p75 in HIV Integration

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Sheehy, A. M., Gaddis, N., Choi, J. D., & Malim, M. H. (2002) · Nature · doi:10.1038/nature00939 · Cited by 2,407

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells

Cherepanov, P., Maertens, G., Proost, P., Devreese, B., Van Beeumen, J., Engelborghs, Y., De Clercq, E., & Debyser, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209278200 · Cited by 704

A role for LEDGF/p75 in targeting HIV DNA integration

Ciuffi, A., Llano, M., Poeschla, E., Hoffmann, C., Leipzig, J., Shinn, P., Ecker, J. R., & Bushman, F. (2005) · Nature Medicine · doi:10.1038/nm1329 · Cited by 658

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., & Engelborghs, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303594200 · Cited by 493

LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but Not Murine Oncoretroviral Integrase Proteins and Is a Component of Functional Lentiviral Preintegration Complexes

Llano, M., Vanegas, M., Fregoso, O., Saenz, D., Chung, S., Peretz, M., & Poeschla, E. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9524-9537.2004 · Cited by 305

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

Ge, H., Si, Y., & Roeder, R. G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6723 · Cited by 299

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase

Cherepanov, P., Devroe, E., Silver, P. A., & Engelman, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406307200 · Cited by 287

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Cherepanov, P., Sun, Z.-Y. J., Rahman, S., Maertens, G., Wagner, G., & Engelman, A. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb937 · Cited by 235

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

Vandekerckhove, L., Christ, F., Maele, B. V., Rijck, J. D., Gijsbers, R., den Haute, C. V., Witvrouw, M., & Debyser, Z. (2006) · Journal of Virology · doi:10.1128/jvi.80.4.1886-1896.2006 · Cited by 210

The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F., & Debyser, Z. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411681200 · Cited by 208

Mobilization of DNA transposable elements from lentiviral vectors

Bak, R. O., & Mikkelsen, J. G. (2011) · Mobile Genetic Elements · doi:10.4161/mge.1.2.17062 · Cited by 4

L368F/V408F double mutant of IBD of LEDGF/p75 retains interaction with M178I mutant of HIV-1 integrase

George, A., & Raghavendra, N. K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.035 · Cited by 4

Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy

Debyser, Z., Desimmie, B. A., Taltynov, O., Demeulemeester, J., & Christ, F. (2014) · MedChemComm · doi:10.1039/c3md00302g · Cited by 4

Prospects for Foamy Viral Vector Anti-HIV Gene Therapy

Nalla, A. K., & Trobridge, G. D. (2016) · Biomedicines · doi:10.3390/biomedicines4020008 · Cited by 5

Current status of targets and assays for anti-HIV drug screening

Tian, R., Liao, Q., & Chen, X. (2007) · Virologica Sinica · doi:10.1007/s12250-007-0049-5 · Cited by 4

Advances in Molecular Retrovirology

Saxena, S. K. (2016) · InTech eBooks · doi:10.5772/60583 · Cited by 4

Cellular Cofactors of HIV Integration

Thys, W., Bartholomeeusen, K., Debyser, Z., & Rijck, J. D. (2011) · Wiley eBooks · doi:10.1002/9781118015377.ch9 · Cited by 4

Strategies for Identification of HIV-1 Integrase Inhibitors

Ramcharan, J., & Skalka, A. M. (2006) · Future Virology · doi:10.2217/17460794.1.6.717 · Cited by 4

The role of chromatin in retroviral preintegration complex function

Sapp, N., Prakash, P., Chakraborty, R., Balasubramaniam, M., & Dash, C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110440 · Cited by 3

Lessons From HIV-1 Gene Therapy in Humanized Mice: Is Targeting Viral Entry the Road to Success?

Petit, N. Y., & Marodon, G. (2016) · Current Gene Therapy · doi:10.2174/1566523216666160104141644 · Cited by 3

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

Suryawanshi, G. W., Arokium, H., Kim, S., Khamaikawin, W., Lin, S., Shimizu, S., Chupradit, K., Lee, Y., Xie, Y., Guan, X., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02601-5 · Cited by 3

Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo

Koh, Y., Ballana, E., Esté, J. A., & Engelman, A. (2013) · AIDS · doi:10.1097/qad.0b013e32835af34c · Cited by 3

A structural model of the HIV-1 Rev-integrase complex: The molecular basis of integrase regulation by Rev

Benyamini, H., Loyter, A., & Friedler, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.116 · Cited by 3

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells

Levin, A., Hayouka, Z., Friedler, A., & Loyter, A. (2010) · Virology Journal · doi:10.1186/1743-422x-7-177 · Cited by 3

Effective prediction model and determination of binding residues influential for inhibitors targeting HIV-1 integrase-LEDGF/p75 interface by employing solvent accessible surface area energy as key determinant

Thangsunan, P., Wongsaipun, S., Kittiwachana, S., & Suree, N. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1580219 · Cited by 3

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity

Tocco, G., Canton, S., Laus, A., Caboni, P., Grice, S. F. J. L., Tramontano, E., & Esposito, F. (2023) · Molecules · doi:10.3390/molecules28186700 · Cited by 3

A comparative study of integrase-binding domain of homologous HRP2 and LEDGF/p75 protein: from sequence to structural characterisation

Kumar, R., Sharma, M. C., Shaikh, N., & Garg, P. (2014) · Molecular Simulation · doi:10.1080/08927022.2014.935374 · Cited by 3

Dialysis Purification of Integrase-DNA Complexes Provides High-Resolution Atomic Force Microscopy Images: Dimeric Recombinant HIV-1 Integrase Binding and Specific Looping on DNA

Tsuruyama, T., NAKAI, T., Ohmori, R., Ozeki, M., Tamaki, K., & Yoshikawa, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053572 · Cited by 3

Interactions of HIV-1 Proteins as Targets for Developing Anti-HIV-1 Peptides

Chandra, K., Maes, M., & Friedler, A. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.46 · Cited by 3

The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking

Ciubotaru, M., Musat, M. G., Surleac, M. D., Ionita, E., Petrescu, A., Abele, E., & Abele, R. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666180406114405 · Cited by 3

Nanotopography-based engineering of retroviral DNA integration patterns

Jang, Y., Park, Y.-S., Nam, J.-S., Yang, Y., Lee, J.-E., Lee, K.-H., Kang, M., Chialastri, A., Noh, H., Park, J., et al. (2019) · Nanoscale · doi:10.1039/c8nr07029f · Cited by 3

Poly (ADP-ribose) polymerase-1 regulates HIV-1 replication in human CD4+ T cellsPreprint

Martinez, Z. S., Gutiérrez, D. A., Valenzuela, C. A., Seong, C.-S., & Llano, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.11.598467 · Cited by 3

Absence of LEDGF/p75 Expression in Astrocytes May Affect HIV-1 Integration Efficiency

Yoder, K. E. (2019) · Molecular Genetics Microbiology and Virology · doi:10.3103/s0891416819020113 · Cited by 2

Molecular Crosstalk between HIV-1 Integration and Host Proteins – Implications for Therapeutics

Suzuki, Y., Suzuki, Y., & Yamamoto, N. (2011) · InTech eBooks · doi:10.5772/23095 · Cited by 2

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Guy, S., Rotem, D., Hayouka, Z., Gabizon, R., Levin, A., Zemel, L., Loyter, A., Porath, D., & Friedler, A. (2013) · Chemical Communications · doi:10.1039/c3cc40748a · Cited by 2

Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan

Georgieva, M., Staneva, D., & Miloshev, G. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-25325-1_2 · Cited by 2

Structural basis for the potent inhibition of the HIV integrase-LEDGF/p75 protein–protein interaction

Ribone, S. R., & Quevedo, M. A. (2017) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2017.05.019 · Cited by 2

LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends

Bueno, M. T. D., Reyes, D., & Llano, M. (2017) · Viruses · doi:10.3390/v9090259 · Cited by 1

Nuclear Pore Complexes, Genome Organization and HIV-1 Infection

Nunzio, F. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-71614-5_8 · Cited by 2

Protein-Protein Interaction Targets to Inhibit HIV-1 Infection

Kadow, J. F., Langley, D. R., Meanwell, N. A., Pracitto, R., Walker, M. A., & Yeung, K. (2012) · Topics in medicinal chemistry · doi:10.1007/978-3-642-28965-1_4 · Cited by 2

Anti-DFS70 among HIV-positive individuals – A prospective study

Mahroum, N., Perez, D., Shovman, O., Watad, ‬., Gilburd, B., Amital, H., Levy, I., & Shoenfeld, Y. (2018) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.01.009 · Cited by 2

Retroviral Integration Target Site Selection

Ciuffi, A., & Bushman, F. D. (2011) · Wiley eBooks · doi:10.1002/9781118015377.ch5 · Cited by 2

Mechanistic and pharmacological analyses of HIV-1 integration

Engelman, A. (2009) · Methods · doi:10.1016/j.ymeth.2009.03.018 · Cited by 2

A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host FactorsPreprint

Hultquist, J. F., Hiatt, J. B., Schumann, K., McGregor, M., Roth, T. L., Haas, P., Doudna, J. A., Marson, A., & Krogan, N. J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/205500 · Cited by 2

Genomic profiling of HIV-1 integration in microglia links viral insertions to TAD organizationPreprint

Rheinberger, M., Costa, A. L., Kampmann, M., Glavaš, D., Shytaj, I. L., Penzo, C., Tibroni, N., Fackler, O., Vlahoviček, K., Lucic, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.14.480322 · Cited by 2

Human Immunodeficiency Virus

Guatelli, J., Siliciano, R. F., Kuritzkes, D. R., & Richman, D. D. (2009) · Wiley eBooks · doi:10.1128/9781555815981.ch33 · Cited by 2

Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genomePreprint

Tedbury, P. R., Mahboubi, D., Puray‐Chavez, M., Shah, R., Ukah, O. B., Wahoski, C. C., Fadel, H. J., Poeschla, E. M., Gao, X., McFadden, W. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.06.627169 · Cited by 2

A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition

Barkova, A., Adhya, I., Conesa, C., Asif-Laidin, A., Bonnet, A., Rabut, E., Chagneau, C., Lesage, P., & Acker, J. (2022) · Mobile DNA · doi:10.1186/s13100-022-00284-0 · Cited by 1

IL-4 downregulates gap junction protein connexin 26 to promote HIV-1 infection in macrophages

Wang, S., Zhang, J., Liu, Y., Zhao, L., Zhang, Y., Liang, G., & Shang, H. (2025) · mBio · doi:10.1128/mbio.01626-25 · Cited by 1

Early pandemic HIV-1 integration site preferences differ across anatomical sites

Kohio, H. P., Ajoge, H. O., Barua, E. A., Vajaria, N. R., Wu, I. K. F., Coleman, M. D., Tom, S. K., van der Meer, F. J. U. M., Gill, M. J., Church, D. L., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01146-5 · Cited by 1

Discovery and optimization of novel and potent allosteric HIV-1 integrase inhibitors with a spiro[indene] moiety

Adachi, K., Manabe, T., Yamasaki, T., Suma, A., Ogoshi, Y., Takahashi, A., Orita, T., Nomura, A., Adachi, T., Ohata, Y., et al. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118526 · Cited by 1

Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells

Tada, T., Kadoki, M., Liu, Y., Tokunaga, K., & Iwakura, Y. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00377 · Cited by 1

Approaches to site-directed DNA integration based on transposases and retroviral integrases

Knyazhanskaya, E. S., Кондрашина, О. В., & Gottikh, M. (2011) · Molecular Biology · doi:10.1134/s0026893311060069 · Cited by 1

Short communication Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance

Lataillade, M., Chiarella, J., & Kozal, M. J. (2007) · Cited by 1

De Novo Design of HIV‐1 Integrase‐LEDGF/p75 Inhibitors Through Deep Reinforcement Learning and Virtual Screening

Sun, H., Wu, H., Wang, T., Chen, A., & Yu, R. (2025) · Journal of Chemometrics · doi:10.1002/cem.70037 · Cited by 1

The significance of anti-DFS70 antibodies in the diagnosis of autoimmune disorders

Nieradko‐Iwanicka, B., Pekar, J., & Skolarczyk, J. (2017) · Family Medicine & Primary Care Review · doi:10.5114/fmpcr.2017.67874 · Cited by 1

Ubiquitination and SUMOylation in HIV Infection: Friends and Foes

Colomer-Lluch, M., Castro‐Gonzalez, S., & Serra-Moreno, R. (2019) · Caister Academic Press eBooks · doi:10.21775/9781912530120.24 · Cited by 1

Resistance to Inhibitors of HIV‐1 Integrase

Hombrouck, A., Clayton, R., Voet, A. R. D., Witvrouw, M., & Debyser, Z. (2011) · Wiley eBooks · doi:10.1002/9781118015377.ch30 · Cited by 1

Characterization of Vif domains that mediate Feline Immunodeficiency Virus antagonism of APOBEC3-H and APOBEC3-CH restrictionPreprint

Sims, O. L., Maynard, E. L., & Poeschla, E. M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/144113 · Cited by 1

Vesiculovirus G protein-based stable cell lines for continuous lentiviral vector production

Tijani, M. (2018) · UCL Discovery (University College London) · Cited by 1

Small molecules effective for disruption of HIV-1 latency

Hashemi, S. P. (2019) · cIRcle (University of British Columbia) · doi:10.14288/1.0383231 · Cited by 1

HIV/AIDS : Antiretroviral Drugs

Geretti, A. M. (2020) · Wiley eBooks · doi:10.1002/9780470015902.a0028523 · Cited by 1

A Lentiviral Envelope Signal Sequence is a Tetherin Antagonizing ProteinPreprint

Morrison, J. H., & Poeschla, E. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.19.457005 · Cited by 1

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modificationPreprint

Sapp, N., Burge, N. L., Cox, K. L., Thapa, S., Prakash, P., Balasubramaniam, M., Christenson, D., Li, M., Linderberger, J., Kvaratskhelia, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.480507 · Cited by 1

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 StrainsPreprint

Montoya, V. R., Ready, T. M., Felton, A., Fine, S. R., OhAinle, M., & Emerman, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.03.515041 · Cited by 1

Transposable Elements

Bonnet, A., Casier, K., Carré, C., Teysset, L., & Lesage, P. (2023) · Wiley eBooks · doi:10.1002/9781394264902.ch3 · Cited by 1

The role of LEDGF in transcription is exploited by HIV-1 to position integrationPreprint

Pathak, R., Esnault, C., Radhakrishnan, R., Singh, P. K., Zhang, H., Dale, R., Anand, A., Bedwell, G. J., Engelman, A., Rabi, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.29.601340 · Cited by 1

NF-κB-Driven HIV-1 Gene Expression in Human Cells Is Independent of Poly(ADP-Ribose) Polymerase-1 FunctionPreprint

Gutiérrez, D. A., & Llano, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.10.642491 · Cited by 1

Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives

Vandekerckhove, L., Christ, F., Debyser, Z., Owen, A., Back, D. J., Voet, A. R. D., Schapiro, J., & Vogelaers, D. (2014) · ASM Press eBooks · doi:10.1128/9781555815493.ch5 · Cited by 1

Role of LEDGF/p75 in Cell Biology and Disease Pathogenesis

Schrijvers, R., & Debyser, Z. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7101-5_72 · Cited by 1

Dévelappement de vecteurs lentiviraux non-intergratifs en vue du transfert de gènes dans le système nerveux central.

Philippe, S. (2007) · HAL

Interactions between a yeast retrotransposon and its host that influence target specificity

Gao, J. (2009) · doi:10.31274/etd-180810-1966

Cloning and characterization of MRI, a modulator of retroviral infection

Agarwal, S. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)

Association of genetic polymorphisms in select HIV-1 replication cofactors with susceptibility to HIV-1 infection and disease progression.

Madlala, P. (2011) · ResearchSpace (University of KwaZulu-Natal)

New Paradigm for Integrase Inhibition: Blocking Enzyme Function without Directly Targeting the Active Site

Al‐Mawsawi, L. Q., & Neamati, N. (2011) · Wiley eBooks · doi:10.1002/9781118015377.ch29

LTR retrotransposons in plants: mechanisms of targeted integration and applications in genome engineering

Hou, Y. (2008) · doi:10.31274/etd-180810-1018

Targeting Integration beyond Strand Transfer: Development of Second‐Generation HIV Integrase Inhibitors

Voet, A. R. D., Maeyer, M. D., Christ, F., & Debyser, Z. (2011) · Methods and principles in medicinal chemistry · doi:10.1002/9783527635955.ch3

Structural aspects of Lentiviral Integrase–LEDGF Interaction

Hare, S., Engelman, A., & Cherepanov, P. (2011) · Wiley eBooks · doi:10.1002/9781118015377.ch10

Retroviral Vectors in Gene Therapy: Mechanism of Integration, Successes in Gene Therapy Trials, Emerging Problems and Potential Solutions

Ahmed, F., Smith, J. A., Lisanti, M. P., & Daniel, R. (2011) · InTech eBooks · doi:10.5772/23016

Geração de células de pluripotência induzida (iPS) humanas utilizando vetores lentivirais e determinação do perfil de integração lentiviral

Reis, L. C. J. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.60.2012.tde-26022013-092913

Human immunodeficiency virus type 1 (HIV-1) reservoirs: mechanisms of latency and therapeutic strategies Eliuth

Anaya, E. D. A., Guarín, C. J. M., & López, M. T. R. (2014) · IATREIA

Sequenciamento de um código de barras como ferramenta para quantificação de alterações na dinâmica de populações celulares transduzidas com vetores lentivirais.

Zanatta, D. B. (2012) · doi:10.11606/t.87.2012.tde-21092012-102415

Targeting HIV‐1 Integrase Zinc Binding Motif

Sechi, M., Carcelli, M., Rogolino, D., & Neamati, N. (2009) · Wiley eBooks · doi:10.1002/9780470508169.ch37

Control of HIV-1C Replication Both in Vivo and in Vitro

Xie, W. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors

Quigley, A. F. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Determinants of HIV-1 Gag Localization to Uropods in Polarized T Cells and the Role Uropods Play in Virus Spread.

Llewellyn, G. N. (2012) · Deep Blue (University of Michigan)

Role of Mitochondria in HIV Infection

Lu, G. (2013)

Inhibiting HIV-1 using RNA interference (RNAi) to target novel HIV dependency factors (HDFs)

Blondeel, M. D. (2010) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

The influence of genetic variation in PSIP1 on HIV-1 infectivity in black South Africans

Gentle, N. L. (2010) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

SURVEY AND SUMMARY Molecular mechanisms of retroviral integration site selection

Kvaratskhelia, M., Sharma, A., Larue, R. C., Serrao, E., & Engelman, A. (2014)

Resistance and HIV infection : resistance development against two new drug candidates and natural variability of the cofactor LEDGF/p75

Hantson, A. (2007)

Host Cell Factors in HIV-1 Replication Cycle

Boso, G. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)

Multimerizationand Modulate Integrase Binding Site of Integrase Block HIV Small-Molecule Inhibitors of the LEDGF/p75

Pickford, C., Chaltin, P., Westby, M., Debyser, Z., Desimmie, B. A., Marchand, A., Frauke, C., Shaw, S. M., & Demeulemeester, J. (2012)

"...the unique multimodal mode of action (of LEDGINs) and the lack of cross-resistance with any known class of ARVs make them excellent candidates for future cART, in particular for patients failing on current therapy."

Christ, F. (2015)

Distribution and characteristics of bovine leukemia virus integration sites in the host genome at three different clinical stages of infection

Wien, S.-V. (2015)

Caracterização de variantes virais de HIV-1 em indivíduos soropositivos com perfil de controle da progressão para a AIDS e da replicação viralavaliação da ocorrência de variantes de escape da resposta imune

Caetano, D. G. (2016) · Americanae (AECID Library)

Characterization of the Myc-JPO2 Transformation Axis in Medulloblastoma

Chan, T. S. Y. (2015) · TSpace (University of Toronto)

Targeting the menin-MLL-LEDGF Interaction with Small Molecule Inhibitors.

Pollock, J. (2016) · Deep Blue (University of Michigan)

Blood CD4 T cells are resistant to cell death by pyroptosis during HIV infection

Muñoz-Arias, I. (2014) · eScholarship (California Digital Library)

SERINC5: Its Sensitivity to Nef and Restriction of HIV-1

Dai, W. (2018) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/1ckn-eb15 · Cited by 1

Characterizing The Role Of The Cellular Protein Schlafen 11 In Flavivirus Replication

Valdez, F. (2018) · DigitalCommons@UTEP (The University of Texas at El Paso)

The Ty1 integrase nuclear localization signal is necessary and sufficient for retrotransposon targeting to tRNA genesPreprint

Asif-Laidin, A., Conesa, C., Bonnet, A., Grison, C., Adhya, I., Menouni, R., Fayol, H., Palmic, N., Acker, J., & Lesage, P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.18.879569

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration biasPreprint

Suryawanshi, G. W., Arokium, H., Kim, S., Khamaikawin, W., Lin, S., Shimizu, S., Chupradit, K., Lee, Y., Xie, Y., Guan, X., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.21.261537

HUBUNGAN KETERBUKAAN STATUS HIV DENGAN STIGMA DIRI PADA ORANG DENGAN HIV/AIDS

Pujilestari, N. I. (2021) · Media Husada Journal Of Nursing Science · doi:10.33475/mhjns.v1i1.8

Next-Generation Sequencing Techniques to Study HIV-1 Transcription and RNA Structure

Tomezsko, P. J. (2020) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Comparative study of Human Immunodeficiency Virus type 1 and type 2 single and dual infections

Yapo, A. V. D. P. (2020) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/83774

BET-independent MLV integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesisPreprint

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