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Cited by 544HIV Research and TreatmentHIV/AIDS drug development and treatmentVirus-based gene therapy research

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

An Essential Role for LEDGF/p75 in HIV Integration

Llano, Manuel, Saenz, Dyana T., Meehan, Anne, Wongthida, Phonphimon, Peretz, Mary, Walker, William H., Teo, Wulin, Poeschla, Eric M.·2006·Science
DOI 10.1126/science.1132319
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Abstract

Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically suppressed but not eradicated. Participation of cellular proteins in this obligate replication step is poorly understood. We used intensified RNA interference and dominant-negative protein approaches to show that the cellular transcriptional coactivator lens epithelium–derived growth factor (LEDGF)/p75 (p75) is an essential HIV integration cofactor. The mechanism requires both linkages of a molecular tether that p75 forms between integrase and chromatin. Fractionally minute levels of endogenous p75 are sufficient to enable integration, showing that cellular factors that engage HIV after entry may elude identification in less intensive knockdowns. Perturbing the p75-integrase interaction may have therapeutic potential.

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Crossref · 10.1126/science.1132319

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Metadata

Authors
Llano, M., Saenz, D. T., Meehan, A., Wongthida, P., Peretz, M., Walker, W. H., Teo, W., & Poeschla, E. M.
Affiliations
Mayo Clinic (US)
Corresponding author
Poeschla, Eric M.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2006-10-20
Volume
314
Issue
5798
Pages
461-464
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1132319
OpenAlex
W2085489729
Cited by
537
References
15
Citations by year
2026: 8 · 2025: 11 · 2024: 15 · 2023: 10 · 2022: 22 · 2021: 21 · 2020: 16 · 2019: 22 · 2018: 18 · 2017: 22 · 2016: 27 · 2015: 28 · 2014: 43 · 2013: 30 · 2012: 45
FWCI
13.66
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
LEDGF/p75, HIV integration, HIV integrase, chromosomal integration, transcriptional coactivator, HIV reservoir, RNAi knockdown, dominant negative protein
MeSH terms
Cell Line, Chromatin, Humans, Recombinant Fusion Proteins, Transcription Factors, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, Virus Integration, HIV Integrase, RNA Interference, Intercellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing

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