Cited by 2,210interferon and immune responsesImmune Response and InflammationRNA regulation and disease

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

Pichlmair, Andreas, Schulz, Oliver, Tan, Choon Ping, Näslund, Tanja I., Liljeström, Peter, Weber, Friedemann, Reis e Sousa, Caetano·2006·Science

DOI 10.1126/science.1132998

Open this paper in CoChat — free account

Abstract

Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.

Integrity signals

Registry

Crossref · 10.1126/science.1132998

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Innate immune recognition of viral infection
Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E. M., Loo, Y., Gale, M., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2851 · Cited by 1,691
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
Theofilopoulos, A. N., Baccalà, R., Beutler, B., & Kono, D. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115843 · Cited by 1,205
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,177
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003
Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses
Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.5059-5064.2006 · Cited by 957
Self-citation
Toll-like receptor 3 promotes cross-priming to virus-infected cells
Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919
Self-citation

Show all 22 references

Research works printed but not linked: 1

D. Knipe P. M. Howley Eds. Fields Virology (Lippincott Williams & Wilkins Philadelphia PA ed. 4 2001).

Sorted by citations

Items 901–1,000 of 1,001

MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication
Li, Z., Luo, Q., Xu, H., Zheng, M., Abdalla, B. A., Feng, M., Cai, B., Zhang, X., Nie, Q., & Zhang, X. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00017 · Cited by 53
Adenosine-to-Inosine RNA Editing in Health and Disease
Gatsiou, A., Vlachogiannis, N. I., Lunella, F. F., Sachse, M., & Stellos, K. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7295 · Cited by 56
Roles of the Non-Structural Proteins of Influenza A Virus
Hao, W., Wang, L., & Li, S. (2020) · Pathogens · doi:10.3390/pathogens9100812 · Cited by 54
Regulation of innate immunity against hepatitis C virus infection
Saito, T., & Gale, M. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00283.x · Cited by 54
Avian Pattern Recognition Receptor Sensing and Signaling
Neerukonda, S. N., & Katneni, U. (2020) · Veterinary Sciences · doi:10.3390/vetsci7010014 · Cited by 57
Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator
Zúñiga, E. I., Hahm, B., & Oldstone, M. B. A. (2007) · Springer eBooks · doi:10.1007/978-3-540-71329-6_16 · Cited by 52
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection
Narita, R., Takahasi, K., Murakami, E., Hirano, E., Yamamoto, S. P., Yoneyama, M., Kato, H., & Fujita, T. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004417 · Cited by 50
Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1-Directed Beta Interferon Transcription by Blocking IRF3 Phosphorylation
Matthys, V. S., Cimica, V., Dalrymple, N. A., Glennon, N. B., Bianco, C., & Mackow, E. R. (2014) · Journal of Virology · doi:10.1128/jvi.02647-13 · Cited by 53
Toll-like Receptor 3 Activation Decreases Porcine Arterivirus Infection
Sang, Y., Ross, C. R., Rowland, R. R. R., & Blecha, F. (2008) · Viral Immunology · doi:10.1089/vim.2008.0042 · Cited by 53
SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity
Liu, D., Sheng, C., Gao, S., Yao, C., Li, J., Jiang, W., Chen, H., Wu, J., Pan, C., Chen, S., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00090-15 · Cited by 53
International Union of Basic and Clinical Pharmacology. XCVI. Pattern Recognition Receptors in Health and Disease
Bryant, C. E., Orr, S. J., Ferguson, B. J., Symmons, M. F., Boyle, J. P., & Monie, T. P. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009928 · Cited by 54
Differential Antagonism of Human Innate Immune Responses by Tick-BornePhlebovirusNonstructural Proteins
Rezelj, V. V., Li, P., Chaudhary, V., Elliott, R. M., Jin, D., & Brennan, B. (2017) · mSphere · doi:10.1128/msphere.00234-17 · Cited by 52
Influenza Virus-Induced Oxidized DNA Activates Inflammasomes
Moriyama, M., Nagai, M., Maruzuru, Y., Koshiba, T., Kawaguchi, Y., & Ichinohe, T. (2020) · iScience · doi:10.1016/j.isci.2020.101270 · Cited by 54
Nonsegmented Negative-Sense RNA Viruses Utilize N 6 -Methyladenosine (m 6 A) as a Common Strategy To Evade Host Innate Immunity
Lu, M., Xue, M., Wang, H.-T., Kairis, E. L., Ahmad, S., Wei, J., Zhang, Z. S., Liu, Q., Zhang, Y., Gao, Y., et al. (2021) · Journal of Virology · doi:10.1128/jvi.01939-20 · Cited by 53
Respiratory Syncytial Virus Induced Type I IFN Production by pDC Is Regulated by RSV-Infected Airway Epithelial Cells, RSV-Exposed Monocytes and Virus Specific Antibodies
Schijf, M. A., Lukens, M. V., Kruijsen, D., van Uden, N. O. P., Garssen, J., Coenjaerts, F. E. J., Land, B. V., & van Bleek, G. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081695 · Cited by 52
Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity
Lee, C., Wu, C. C., & Lin, T. L. (2014) · Archives of Virology · doi:10.1007/s00705-014-1983-9 · Cited by 52
Mitochondrial dynamics and the innate antiviral immune response
Pourcelot, M., & Arnoult, D. (2014) · FEBS Journal · doi:10.1111/febs.12940 · Cited by 50
RIG-I ATPase Activity and Discrimination of Self-RNA versus Non-Self-RNA
Anchisi, S., Guerra, J., & Garcin, D. (2015) · mBio · doi:10.1128/mbio.02349-14 · Cited by 52
c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-β production and cellular antiviral response
Zhao, X., Zhu, H., Yu, J., Li, H., Ge, J., & Chen, W. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.08.002 · Cited by 51
Endogenous Retroelements and the Host Innate Immune Sensors
Mu, X. N., Ahmad, S., & Hur, S. (2016) · Advances in immunology · doi:10.1016/bs.ai.2016.07.001 · Cited by 56
CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo
Teng, O., Chen, S.-T., Hsu, T.-L., Sia, S. F., Cole, S., Valkenburg, S. A., Hsu, T.-Y., Zheng, J. T., Tu, W., Bruzzone, R., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01813-16 · Cited by 53
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling
Núñez, R. D., Budt, M., Saenger, S., Paki, K., Arnold, U., Sadewasser, A., & Wolff, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071877 · Cited by 52
LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs
Takahashi, T., Nakano, Y., Onomoto, K., Murakami, F., Komori, C., Suzuki, Y., Yoneyama, M., & Ui‐Tei, K. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky575 · Cited by 51
Adenosine-to-inosine RNA editing in the immune system: friend or foe?
Nakahama, T., & Kawahara, Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03466-2 · Cited by 51
Cytokine-Independent Upregulation of MDA5 in Viral Infection
Yount, J. S., Moran, T. M., & López, C. B. (2007) · Journal of Virology · doi:10.1128/jvi.00545-07 · Cited by 52
Viral miRNA regulation of host gene expression
Diggins, N. L., & Hancock, M. H. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.11.007 · Cited by 50
RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs
Simon, A. E., & Gehrke, L. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.05.005 · Cited by 54
Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway
Lencer, W. I., Luca, H. E. D., Grey, M. J., & Cho, J. A. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.05.006 · Cited by 51
Fish MAVS is involved in RLR pathway-mediated IFN response
Zhang, J., Zhang, Y.-B., Wu, M., Wang, B., Chen, C., & Gui, J. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.09.002 · Cited by 51
Silencing the alarms: Innate immune antagonism by rotavirus NSP1 and VP3
Morelli, M., Ogden, K. M., & Patton, J. T. (2015) · Virology · doi:10.1016/j.virol.2015.01.006 · Cited by 51
Immunization with Live Attenuated Influenza Viruses That Express Altered NS1 Proteins Results in Potent and Protective Memory CD8 + T-Cell Responses
Mueller, S. N., Langley, W. A., Carnero, E., García‐Sastre, A., & Ahmed, R. (2009) · Journal of Virology · doi:10.1128/jvi.01317-09 · Cited by 51
Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium
Hsu, A., Parsons, K. S., Moheimani, F., Knight, D. A., Hansbro, P. M., Fujita, T., & Wark, P. A. B. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0306oc · Cited by 51
Characterization and immune response expression of the R ig‐ I ‐like receptor mda5 in common carp Cyprinus carpio
Zhu, Y., Xing, W., Shan, S., Zhang, S. Q., Li, Y. Q., Li, T., An, L., & Yang, G. (2016) · Journal of Fish Biology · doi:10.1111/jfb.12981 · Cited by 51
The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases
Chou, C., Chang, Y., Kořínek, M., Chen, Y., Yang, Y.-T., Leu, S., Lin, I., Tang, C.-J., & Chiu, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030483 · Cited by 52
Host Protective Immune Responses against Influenza A Virus Infection
Jung, H. E., & Lee, H. K. (2020) · Viruses · doi:10.3390/v12050504 · Cited by 55
RIG‐I mediates nonsegmented negative‐sense RNA virus‐induced inflammatory immune responses of primary human astrocytes
Furr, S. R., Moerdyk-Schauwecker, M. J., Grdzelishvili, V. Z., & Marriott, I. (2010) · Glia · doi:10.1002/glia.21034 · Cited by 51
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
Maharana, S., Kretschmer, S., Hunger, S., Yan, X., Kuster, D., Traikov, S., Zillinger, T., Gentzel, M., Elangovan, S., Dasgupta, P., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.08.031 · Cited by 53
Nsp16 shields SARS–CoV‐2 from efficient MDA5 sensing and IFIT1‐mediated restriction
Russ, A., Wittmann, S., Tsukamoto, Y., Herrmann, A., Deutschmann, J., Lagisquet, J., Ensser, A., Kato, H., & Gramberg, T. (2022) · EMBO Reports · doi:10.15252/embr.202255648 · Cited by 50
Viral RNA in the influenza vaccine may have contributed to the development of ANCA-associated vasculitis in a patient following immunisation
Jeffs, L., Nitschke, J., Tervaert, J. W. C., Peh, C. A., & Hurtado, P. R. (2015) · Clinical Rheumatology · doi:10.1007/s10067-015-3073-0 · Cited by 50
Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA)
Mansoori, B., Mohammadi, A., Shirjang, S., & Baradaran, B. (2015) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2015.1102738 · Cited by 50
Innate Immune Responses in Human Monocyte-Derived Dendritic Cells Are Highly Dependent on the Size and the 5′ Phosphorylation of RNA Molecules
Jiang, M., Österlund, P., Sarin, L. P., Poranen, M. M., Bamford, D. H., Guo, D., & Julkunen, I. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100361 · Cited by 55
Cytosolic RNA Recognition Pathway Activates 14-3-3 Protein Mediated Signaling and Caspase-Dependent Disruption of Cytokeratin Network in Human Keratinocytes
Öhman, T., Lietzén, N., Välimäki, E., Melchjorsen, J., Matikainen, S., & Nyman, T. A. (2010) · Journal of Proteome Research · doi:10.1021/pr901040u · Cited by 50
Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation
Paulmann, D., Magulski, T., Schwarz, R. L., Heitmann, L., Flehmig, B., Vallbracht, A., & Dotzauer, A. (2008) · Journal of General Virology · doi:10.1099/vir.0.83521-0 · Cited by 50
Gemcitabine, a broad-spectrum antiviral drug, suppresses enterovirus infections through innate immunity induced by the inhibition of pyrimidine biosynthesis and nucleotide depletion
Lee, K., Kim, D., Jang, K., Kim, S., Cho, S., & Kim, C. (2017) · Oncotarget · doi:10.18632/oncotarget.23258 · Cited by 50
The dual role of innate immunity during influenza
Biondo, C., Lentini, G., Beninati, C., & Teti, G. (2019) · Biomedical Journal · doi:10.1016/j.bj.2018.12.009 · Cited by 53
Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy
Pila‐Castellanos, I., Molino, D., McKellar, J., Linès, L., Graça, J. D., Tauziet, M., Chanteloup, L., Mikaélian, I., Meyniel‐Schicklin, L., Codogno, P., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009340 · Cited by 50
Innate Immune Responses to Hepatitis C Virus
Schoggins, J. W., & Rice, C. M. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-27340-7_9 · Cited by 52
Translational Mini-Review Series on Toll-like Receptors: Recent advances in understanding the role of Toll-like receptors in anti-viral immunity
Bowie, A. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03301.x · Cited by 50
IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus
Demoor, T., Petersen, B., Morris, S. B., Mukherjee, S., Ptaschinski, C., Nagata, D. D. A., Kawai, T., Ito, T., Akira, S., Kunkel, S. L., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201763 · Cited by 51
Camouflage and interception: how pathogens evade detection by intracellular nucleic acid sensors
Unterholzner, L., & Almine, J. F. (2018) · Immunology · doi:10.1111/imm.13030 · Cited by 48
The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas
Zhang, Y., Yu, F., Li, J., Tong, Y., Zhang, Y., & Yu, Z. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.07.029 · Cited by 49
Interferon Induced with Helicase C Domain 1 (IFIH1) and Virus-Induced Autoimmunity: A Review
Chistiakov, D. A. (2010) · Viral Immunology · doi:10.1089/vim.2009.0071 · Cited by 49
GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses
Chiang, H.-S., Zhao, Y., Song, J.-H., Liu, S., Wang, N., Terhorst, C., Sharpe, A. H., Basavappa, M. G., Jeffrey, K. L., & Reinecker, H. (2013) · Nature Immunology · doi:10.1038/ni.2766 · Cited by 49
Ancient Origins of Vertebrate-Specific Innate Antiviral Immunity
Mukherjee, K., Korithoski, B., & Kolaczkowski, B. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst184 · Cited by 48
The selective footprints of viral pressures at the human RIG-I-like receptor family
Vasseur, E., Patin, É., Laval, G., Pajon, S., Fornarino, S., Crouau‐Roy, B., & Quintana‐Murci, L. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr377 · Cited by 54
Defining the subcellular sites of innate immune signal transduction
Kagan, J. C. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.06.005 · Cited by 51
Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling
Zheng, J., Yang, P., Tang, Y., Pan, Z., & Zhao, D. (2015) · Journal of Immunology Research · doi:10.1155/2015/738547 · Cited by 48
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
Shi, Y., Yuan, B., Qi, N., Zhu, W., Su, J., Li, X., Qi, P., Zhang, D., & Hou, F. (2015) · Nature Communications · doi:10.1038/ncomms8811 · Cited by 50
The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection
Ramanathan, A., Devarkar, S. C., Jiang, F., Miller, M. T., Khan, A. G., Marcotrigiano, J., & Patel, S. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1299 · Cited by 49
Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR
Schierhorn, K. L., Jolmes, F., Bespalowa, J., Saenger, S., Peteranderl, C., Dzieciolowski, J., Mielke, M., Budt, M., Pleschka, S., Herrmann, A., et al. (2017) · Journal of Virology · doi:10.1128/jvi.00198-17 · Cited by 49
Checks and Balances between Autophagy and Inflammasomes during Infection
Seveau, S. M., Turner, J., Gavrilin, M. A., Torrelles, J. B., Hall‐Stoodley, L., Yount, J. S., & Amer, A. O. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.11.006 · Cited by 47
Defective RNA sensing by RIG-I in severe influenza virus infection
Jørgensen, S. E., Christiansen, M., Ryø, L. B., Gad, H. H., Gjedsted, J., Staeheli, P., Mikkelsen, J. G., Storgaard, M., Hartmann, R., & Mogensen, T. H. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13120 · Cited by 49
PA-X: a key regulator of influenza A virus pathogenicity and host immune responses
Hu, J., Ma, C., & Liu, X. (2018) · Medical Microbiology and Immunology · doi:10.1007/s00430-018-0548-z · Cited by 52
The uric acid crystal receptor Clec12A potentiates type I interferon responses
Li, K., Neumann, K., Duhan, V., Namineni, S., Hansen, A. L., Wartewig, T., Kurgyis, Z., Holm, C. K., Heikenwälder, M. F., Lang, K. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821351116 · Cited by 49
Know Thyself: RIG-I-Like Receptor Sensing of DNA Virus Infection
Zhao, Y., & Karijolich, J. J. (2019) · Journal of Virology · doi:10.1128/jvi.01085-19 · Cited by 49
Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR
Dauber, B., Martínez‐Sobrido, L., Schneider, J., Hai, R., Waibler, Z., Kalinke, U., García‐Sastre, A., & Wolff, T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000473 · Cited by 49
Intracellular pattern-recognition receptors☆
Dostert, C., Meylan, E., & Tschopp, J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.12.003 · Cited by 50
Potential health risks of mRNA-based vaccine therapy: A hypothesis
Acevedo‐Whitehouse, K. A., & Bruno, R. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111015 · Cited by 56
The interferon inducing pathways and the hepatitis C virus
MEURS, E. F. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i17.2446 · Cited by 48
Activation and regulation of pathogen sensor RIG-I
Patel, J. R., & García‐Sastre, A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.08.005 · Cited by 50
Molecular mechanisms of viral inhibitors of RIG-I-like receptors
Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2011.12.005 · Cited by 49
Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway
Cheng, J., Sun, Y., Zhang, X., Zhang, F., Zhang, S., Yu, S., Qiu, X., Tan, L., Song, C., Gao, S., et al. (2014) · Archives of Virology · doi:10.1007/s00705-014-2148-6 · Cited by 46
Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner
Walkiewicz, M. P., Basu, D., Jablonski, J. J., Geysen, H. M., & Engel, D. A. (2010) · Journal of General Virology · doi:10.1099/vir.0.025015-0 · Cited by 48
Qualitatively Different Memory CD8+ T Cells Are Generated after Lymphocytic Choriomeningitis Virus and Influenza Virus Infections
Mueller, S. N., Langley, W. A., Li, G., García‐Sastre, A., Webby, R. J., & Ahmed, R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001142 · Cited by 48
DUSP11 – An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells
Burke, J. M., & Sullivan, C. S. (2017) · RNA Biology · doi:10.1080/15476286.2017.1306169 · Cited by 47
Interplay between dengue virus and Toll-like receptors, RIG-I/MDA5 and microRNAs: Implications for pathogenesis
Inchima, S. U., Cabrera, J., & Haenni, A. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.09.017 · Cited by 49
NSs Encoded by Groundnut Bud Necrosis Virus Is a Bifunctional Enzyme
Bhushan, L., Rashmi, P. R., Amruta, B. S., Dharmaiah, S., Murthy, M. R. N., & Savithri, H. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009757 · Cited by 48
Persistent and Stable Gene Expression by a Cytoplasmic RNA Replicon Based on a Noncytopathic Variant Sendai Virus
Nishimura, K., Segawa, H., Goto, T., Morishita, M., Masago, A., Takahashi, H., Ohmiya, Y., Sakaguchi, T., Asada, M., Imamura, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702028200 · Cited by 48
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Abdelmoaty, M. M., Yeapuri, P., Machhi, J., Olson, K. E., Shahjin, F., Kumar, V. S., Zhou, Y., Liang, J., Pandey, K., Acharya, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741502 · Cited by 47
Innate immune regulations and various siRNA modalities
Kaushal, A. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01361-4 · Cited by 52
Characterization of mRNA therapeutics
Guimaraes, G. J., Kim, J., & Bartlett, M. G. (2023) · Mass Spectrometry Reviews · doi:10.1002/mas.21856 · Cited by 50
RIG-I and dsRNA-Induced IFNβ Activation
Hausmann, S., Marq, J., Tapparel, C., Kolakofsky, D., & Garcin, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003965 · Cited by 47
Multi-level regulation of cellular recognition of viral dsRNA
Peisley, A., & Hur, S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1149-4 · Cited by 46
RIG-I activation inhibits ebolavirus replication
Spiropoulou, C. F., Ranjan, P., Pearce, M. B., Sealy, T. K., Albariño, C. G., Gangappa, S., Fujita, T., Rollin, P. E., Nichol, S. T., Ksiazek, T. G., et al. (2009) · Virology · doi:10.1016/j.virol.2009.06.032 · Cited by 47
Sensing and Control of Bluetongue Virus Infection in Epithelial Cells via RIG-I and MDA5 Helicases
Chauveau, E., Doceul, V., Lara, E., Adam, M., Bréard, E., Sailleau, C., Viarouge, C., Desprat, A., Meyer, G., Schwartz-Cornil, I., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00430-12 · Cited by 47
Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1
Li, M.-T., Di, W., Xu, H. Y., Yang, Y., Chen, H.-W., Zhang, F., Zhai, Z., & Chen, D. (2013) · Journal of Virology · doi:10.1128/jvi.01073-13 · Cited by 47
Interferon in Rabies Virus Infection
Rieder, M., & Conzelmann, K. (2011) · Advances in virus research · doi:10.1016/b978-0-12-387040-7.00006-8 · Cited by 49
LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV
Xiao, J., Yan, J., Chen, H., Li, J., Tian, Y., & Feng, H. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.08.031 · Cited by 47
RIG-I Detects Kaposi’s Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner
Zhang, Y., Dittmer, D. P., Mieczkowski, P. A., Host, K. M., Fusco, W. G., Duncan, J. A., & Damania, B. (2018) · mBio · doi:10.1128/mbio.00823-18 · Cited by 47
The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity
Zong, Z., Zhang, Z., Wu, L., Zhang, L., & Zhou, F. (2020) · Advanced Science · doi:10.1002/advs.202002484 · Cited by 49
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I
Jureka, A. S., Kleinpeter, A. B., Tipper, J. L., Harrod, K. S., & Petit, C. M. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49923-6 · Cited by 47
Vesicular Stomatitis Virus mRNA Capping Machinery Requires Specific cis -Acting Signals in the RNA
Wang, J., McElvain, L. E., & Whelan, S. P. J. (2007) · Journal of Virology · doi:10.1128/jvi.01057-07 · Cited by 47
Emerging Principles Governing Signal Transduction by Pattern-Recognition Receptors: Table 1.Preprint
Kagan, J. C., & Barton, G. M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016253 · Cited by 49
Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene I
Li, W., Chen, H., Sutton, T. C., Obadan, A. O., & Perez, D. R. (2014) · Journal of Virology · doi:10.1128/jvi.01383-14 · Cited by 46
Exploiting viral properties for the rational design of modern vaccines
Spohn, G., & Bachmann, M. F. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.1.43 · Cited by 46
The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways
Tisoncik-Go, J., Billharz, R., Burmakina, S., Belisle, S. E., Proll, S. C., Korth, M. J., García‐Sastre, A., & Katze, M. G. (2011) · Journal of General Virology · doi:10.1099/vir.0.032060-0 · Cited by 46
The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts
Drews, K., Tavernier, G., Demeester, J., Lehrach, H. R., Smedt, S. C. D., Rejman, J., & Adjaye, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.025 · Cited by 46
Both Conventional and Interferon Killer Dendritic Cells Have Antigen-Presenting Capacity during Influenza Virus Infection
GeurtsvanKessel, C. H., Bergen, I. M., Muskens, F., Boon, L., Hoogsteden, H. C., Osterhaus, A. D. M. E., Rimmelzwaan, G. F., & Lambrecht, B. N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007187 · Cited by 46
DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity
Zhu, Q., Tan, P., Li, Y., Lin, M., Li, C., Mao, J., Cui, J., Zhao, W., Wang, H. Y., & Wang, R. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006886 · Cited by 46
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients
Sioud, M., Sæbøe‐Larssen, S., Falkenthal, T. E. H., Kærn, J., Mobergslien, A., & Kvalheim, G. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1922 · Cited by 47

Authors: Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C.
Affiliations: University of Freiburg (DE)
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
ORCID: Pichlmair, Andreas
Schulz, Oliver
Weber, Friedemann
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2006-11-10
Volume: 314
Issue: 5801
Pages: 997-1001
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1132998
OpenAlex: W2009127910
Cited by: 2,210
References: 22
Citations by year: 2026: 40 · 2025: 55 · 2024: 64 · 2023: 55 · 2022: 89 · 2021: 94 · 2020: 116 · 2019: 95 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 111 · 2014: 137 · 2013: 148 · 2012: 127
FWCI: 59.07
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: RIG-I, MDA5, single-stranded RNA, influenza A virus, NS1 protein, antiviral innate immunity, RNA helicase, self/non-self discrimination, viral immune evasion, double-stranded RNA
MeSH terms: DEAD Box Protein 58, Animals, Cell Line, Cells, Cultured, Cytoplasm, Dendritic Cells, Encephalomyocarditis virus, Humans, Immunity, Innate, Mice, Inbred C57BL, Influenza A virus, Phosphates, Phosphorylation, Receptors, Immunologic, Recombinant Fusion Proteins, RNA Caps, RNA, Double-Stranded, RNA, Viral, Transfection, Vesicular stomatitis Indiana virus, Virus Replication, Genome, Viral, Interferon-alpha, Interferon-beta, Viral Nonstructural Proteins, Mice, DEAD-box RNA Helicases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks