The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Abstract
Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.
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“However, several RNA structural features have been described as immunostimulatory due to interactions with various RNA sensors such as Toll-like receptors, RIG-I, and PKR.”
From Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals (2015) · cites this paper as [12]
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Cites
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Innate immune recognition of viral infection
Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899
Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E. M., Loo, Y., Gale, M., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2851 · Cited by 1,691
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
Theofilopoulos, A. N., Baccalà, R., Beutler, B., & Kono, D. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115843 · Cited by 1,205
Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,177
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003
Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.5059-5064.2006 · Cited by 957
Self-citationToll-like receptor 3 promotes cross-priming to virus-infected cells
Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919
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- D. Knipe P. M. Howley Eds. Fields Virology (Lippincott Williams & Wilkins Philadelphia PA ed. 4 2001).
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Yoshioka, N., & Dowdy, S. F. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182018 · Cited by 36
Metadata
- Authors
- Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C.
- Affiliations
- University of Freiburg (DE)
- Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
- Venue
- Science
- Published
- 2006-11-10
- Volume
- 314
- Issue
- 5801
- Pages
- 997-1001
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009127910
- Cited by
- 2,210
- References
- 22
- Citations by year
- 2026: 40 · 2025: 55 · 2024: 64 · 2023: 55 · 2022: 89 · 2021: 94 · 2020: 116 · 2019: 95 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 111 · 2014: 137 · 2013: 148 · 2012: 127
- FWCI
- 59.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- RIG-I, MDA5, single-stranded RNA, influenza A virus, NS1 protein, antiviral innate immunity, RNA helicase, self/non-self discrimination, viral immune evasion, double-stranded RNA
- MeSH terms
- DEAD Box Protein 58, Animals, Cell Line, Cells, Cultured, Cytoplasm, Dendritic Cells, Encephalomyocarditis virus, Humans, Immunity, Innate, Mice, Inbred C57BL, Influenza A virus, Phosphates, Phosphorylation, Receptors, Immunologic, Recombinant Fusion Proteins, RNA Caps, RNA, Double-Stranded, RNA, Viral, Transfection, Vesicular stomatitis Indiana virus, Virus Replication, Genome, Viral, Interferon-alpha, Interferon-beta, Viral Nonstructural Proteins, Mice, DEAD-box RNA Helicases
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