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High-Throughput Identification of Catalytic Redox-Active Cysteine Residues
Abstract
Cysteine (Cys) residues often play critical roles in proteins; however, identification of their specific functions has been limited to case-by-case experimental approaches. We developed a procedure for high-throughput identification of catalytic redox-active Cys in proteins by searching for sporadic selenocysteine-Cys pairs in sequence databases. This method is independent of protein family, structure, and taxon. We used it to selectively detect the majority of known proteins with redox-active Cys and to make additional predictions, one of which was verified. Rapid accumulation of sequence information from genomic and metagenomic projects should allow detection of many additional oxidoreductase families as well as identification of redox-active Cys in these proteins.
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Citations
Cited by
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Quantitative reactivity profiling predicts functional cysteines in proteomes
Weerapana, E., Wang, C., Simon, G. M., Richter, F., Khare, S., Dillon, M. B. D., Bachovchin, D. A., Mowen, K., Baker, D., & Cravatt, B. F. (2010) · Nature · doi:10.1038/nature09472 · Cited by 1,684
Arsenic Exposure and Toxicology: A Historical Perspective
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., & Thomas, D. J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr184 · Cited by 1,312
Self-citationThe basics of thiols and cysteines in redox biology and chemistry
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Metadata
- Authors
- Fomenko, D. E., Xing, W., Adair, B. M., Thomas, D. J., & Gladyshev, V. N.
- Venue
- Science
- Published
- 2007-01-19
- Volume
- 315
- Issue
- 5810
- Pages
- 387-389
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001499411
- Cited by
- 187
- References
- 0
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fomenko, D. E., Xing, W., Adair, B. M., Thomas, D. J., & Gladyshev, V. N. (2007). High-Throughput Identification of Catalytic Redox-Active Cysteine Residues. Science. https://doi.org/10.1126/science.1133114
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