Signal transduction by reactive oxygen species

Finkel, Toren

doi:10.1083/jcb.201102095

Cited by 2,322Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

Signal transduction by reactive oxygen species

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Finkel, Toren·2011·Journal of Cell Biology

DOI 10.1083/jcb.201102095PMC PMC3135394

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Abstract

Although historically viewed as purely harmful, recent evidence suggests that reactive oxygen species (ROS) function as important physiological regulators of intracellular signaling pathways. The specific effects of ROS are modulated in large part through the covalent modification of specific cysteine residues found within redox-sensitive target proteins. Oxidation of these specific and reactive cysteine residues in turn can lead to the reversible modification of enzymatic activity. Emerging evidence suggests that ROS regulate diverse physiological parameters ranging from the response to growth factor stimulation to the generation of the inflammatory response, and that dysregulated ROS signaling may contribute to a host of human diseases.

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High levels of ROS generated by ongoing aerobic glycolysis followed by pyruvate oxidation in mitochondria (the Warburg effect) increase receptor and oncogene activity and induce genetic instability.
“high levels of ROS generated by ongoing aerobic glycolysis followed by pyruvate oxidation in mitochondria (the Warburg effect), increase receptor and oncogene activity, and the stimulation of growth factor-dependent pathways or oxidizing enzymes induce genetic instability3,4.”
From ROS in cancer therapy: the bright side of the moon (2020) · cites this paper as [4]
In “Oxidants and their cellular targets” (page unavailable), the paper says mitochondria produce ROS during aerobic respiration and that ROS are involved in growth-factor signaling. It does not link those effects to the claimed Warburg-effect sequence, establish increased oncogene activity, or say that these pathways induce genetic instability. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Generation of superoxide and hydrogen peroxide mediates critical processes such as angiogenesis, hypoxic adaptation, and energy homeostasis.
“Indeed, the generation of superoxide and hydrogen peroxide, among others, has been shown to mediate critical processes such as angiogenesis, hypoxic adaptation, and energy homeostasis (96, 249, 291, 720, 778, 825, 960).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [291]
ROS have origin from two main sources: mitochondrial oxidative metabolism and processes of cellular response to xenobiotics, bacteria, and cytokines during which ROS are formed as part of signal transduction or defense.
“As outlined above, ROS have origin from two main sources: mitochondrial oxidative metabolism and processes of cellular response to xenobiotics, bacteria, and cytokines during which ROS are formed as a part of either signal transduction pathways or a cellular defense mechanism (Finkel 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Finkel 2011

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Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.
Kamsler, A., Daily, D., Hochman, A., Stern, N., Shiloh, Y., Rotman, G., & Barzilai, A. (2001) · PubMed · Cited by 235 · see citing works
Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation
Gloire, G., & Piette, J. G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2463 · Cited by 220 · see citing works
Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity
Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works
Beobachtungen über die Oxydationsprozesse im Seeigelei.
Warburg, O. H. (1908) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1908.57.1-2.1 · Cited by 203 · see citing works
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 201 · see citing works
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis
Eaton, J. S., Lin, Z. P., Sartorelli, A. C., Bonawitz, N. D., & Shadel, G. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31604 · Cited by 196 · see citing works
Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway
Kim, J., Huang, T. Y., & Bokoch, G. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-02-0131 · Cited by 188 · see citing works
High-Throughput Identification of Catalytic Redox-Active Cysteine Residues
Fomenko, D. E., Xing, W., Adair, B. M., Thomas, D. J., & Gladyshev, V. N. (2007) · Science · doi:10.1126/science.1133114 · Cited by 187 · see citing works
The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway
Seo, J. H., Ahn, Y., Lee, S.-R., Yeo, C., & Hur, K. C. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0369 · Cited by 175 · see citing works
Elevated Oxidative Stress in Patients with Ataxia Telangiectasia
Reichenbach, J., Schubert, R., Schindler, D., Müller, K., Böhles, H., & Zielen, S. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196254 · Cited by 173 · see citing works
Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling
Miller, E. W., & Chang, C. J. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.09.018 · Cited by 168 · see citing works
Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals
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Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
Heidler, T., Hartwig, K., Daniel, H., & Wenzel, U. (2009) · Biogerontology · doi:10.1007/s10522-009-9239-x · Cited by 156 · see citing works
Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex
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v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway
Teng, K. K., Lander, H. M., Fajardo, J. E., Hanafusa, H., Hempstead, B. L., & Birge, R. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20677 · Cited by 148 · see citing works
Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling
de Keizer, P. L. J., Burgering, B. M. T., & Dansen, T. B. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3403 · Cited by 131 · see citing works
S‐glutathiolation by peroxynitrite of p21ras at cysteine‐118 mediates its direct activation and downstream signaling in endothelial cells
Clavreul, N., Adachi, T. K., Pimental, D. R., Ido, Y., Schöneich, C., & Cohen, R. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4875fje · Cited by 130 · see citing works
The Oxidative Burst at Fertilization Is Dependent upon Activation of the Dual Oxidase Udx1
Wong, J. L., Créton, R., & Wessel, G. M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.014 · Cited by 128 · see citing works
Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice
Reliene, R., & Schiestl, R. H. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.003 · Cited by 97 · see citing works
Mapping the cysteine proteome: analysis of redox-sensing thiols
Jones, D. P., & Go, Y. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.12.014 · Cited by 89 · see citing works
Peroxiredoxin 1 Interacts with Androgen Receptor and Enhances Its Transactivation
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Reactive Oxygen Species-mediated Regulation of Mitochondrial Biogenesis in the Yeast Saccharomyces cerevisiae
Chevtzoff, C., Yoboue, E. D., Galinier, A., Casteilla, L., Daignan‐Fornier, B., Rigoulet, M., & Devin, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019570 · Cited by 72 · see citing works
Sending ROS on a Bullet Train
Wong, H. L., & Shimamoto, K. (2009) · Science Signaling · doi:10.1126/scisignal.290pe60 · Cited by 24 · see citing works

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ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works
Reactive Oxygen Species and Antioxidant Defense in Plants under Abiotic Stress: Revisiting the Crucial Role of a Universal Defense Regulator
Hasanuzzaman, M., Bhuyan, M. H. M. B., Zulfiqar, F., Raza, A., Mohsin, S. M., Mahmud, J. A., Fujita, M., & Fotopoulos, V. (2020) · Antioxidants · doi:10.3390/antiox9080681 · Cited by 3,137 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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ROS in cancer therapy: the bright side of the moon
Perillo, B., Di Donato, M., Pezone, A., Di Zazzo, E., Giovannelli, P., Galasso, G., Castoria, G., & Migliaccio, A. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0384-2 · Cited by 2,176 · see citing works
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling
Wang, Y., Branicky, R. S., Noë, A., & Hekimi, S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708007 · Cited by 2,199 · see citing works
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. S. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,104 · see citing works
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works
Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971 · see citing works
ROS signalling in the biology of cancer
Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 1,983 · see citing works
Ros and ros-mediated cellular signaling
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980 · see citing works
NRF2 and the Hallmarks of Cancer
Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672 · see citing works
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619 · see citing works
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age‐Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
Nita, M., & Grzybowski, A. E. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3164734 · Cited by 1,451 · see citing works
Ageing and the pathogenesis of osteoarthritis
Loeser, R. F., Collins, J. A., & Diekman, B. O. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.65 · Cited by 1,309 · see citing works
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Paulsen, C. E., & Carroll, K. S. (2013) · Chemical Reviews · doi:10.1021/cr300163e · Cited by 1,283 · see citing works
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works
The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles
Dayem, A. A., Hossain, M., Lee, S., Kim, K., Saha, S. K., Yang, G., Choi, H. J., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010120 · Cited by 1,154 · see citing works
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
Links between metabolism and cancerPreprint
Dang, C. V. (2012) · Genes & Development · doi:10.1101/gad.189365.112 · Cited by 991 · see citing works
Recent Advances in Nanozyme Research
Wang, H., Wan, K., & Shi, X. (2018) · Advanced Materials · doi:10.1002/adma.201805368 · Cited by 979 · see citing works
Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways
Hakim, M., Broza, Y. Y., Barash, O., Peled, N., Phillips, M., Amann, A., & Haick, H. (2012) · Chemical Reviews · doi:10.1021/cr300174a · Cited by 953 · see citing works
Antioxidant Properties of Probiotic Bacteria
Wang, Y., Wu, Y., Wang, Y., Xu, H., 梅小强, Yu, D., Wang, Y., & Li, W. (2017) · Nutrients · doi:10.3390/nu9050521 · Cited by 922 · see citing works
Free radicals and antioxidants: updating a personal view
Halliwell, B. B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 918 · see citing works
Molecular mechanisms of ROS production and oxidative stress in diabetes
Newsholme, P., Cruzat, V. F., Keane, K. N., Carlessi, R., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160503c · Cited by 878 · see citing works
The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment
Schulte, P. M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.118851 · Cited by 878 · see citing works
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?
Senoner, T., & Dichtl, W. (2019) · Nutrients · doi:10.3390/nu11092090 · Cited by 880 · see citing works
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837 · see citing works
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
Cadenas, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.024 · Cited by 819 · see citing works
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers
Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 810 · see citing works
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K. B., Wang, L., & Handa, J. T. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.002 · Cited by 814 · see citing works
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency
McMurray, R. J., Gadegaard, N., Tsimbouri, P. M., Burgess, K., McNamara, L. E., Tare, R. S., Murawski, K., Kingham, E., Oreffo, R. O. C., & Dalby, M. J. (2011) · Nature Materials · doi:10.1038/nmat3058 · Cited by 779 · see citing works
Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide
Bienert, G. P., & Chaumont, F. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.017 · Cited by 736 · see citing works
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · see citing works
“Indeed, oxidative stress has been implicated in aging (Lambert et al., 2007) and development of a variety of diseases, including cancer (Toyokuni et al., 1995), type 2 diabetes (Brownlee, 2001), atherosclerosis (Galkina and Ley, 2009), and neurodegeneration (Lin and Beal, 2006).”
Background
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
Tormos, K. V., Ansó, E., Hamanaka, R. B., Eisenbart, J. D., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 660 · see citing works
The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review
Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 655 · see citing works
Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling
Perkins, A., Nelson, K. J., Parsonage, D., Poole, L. B., & Karplus, P. A. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.05.001 · Cited by 648 · see citing works
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
Stem cells and the impact of ROS signaling
Bigarella, C. L., Liang, R. H.-S., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 627 · see citing works
Apoptosis and Oxidative Stress in Neurodegenerative Diseases
Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 632 · see citing works
Mitohormesis
Yun, J., & Finkel, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.011 · Cited by 626 · see citing works
Self-citation
A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress
Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre dâ€™Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600 · see citing works
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes
Shah, M. S., & Brownlee, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.306923 · Cited by 601 · see citing works
Reactive oxygen species: from health to disease
Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133 · see citing works
Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling
Sobotta, M. C., Liou, W., Stöcker, S., Talwar, D., Oehler, M., Ruppert, T., Scharf, A. N. D., & Dick, T. P. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1695 · Cited by 598 · see citing works
The Two Faces of Reactive Oxygen Species in Cancer
Reczek, C. R., & Chandel, N. S. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041916-065808 · Cited by 602 · see citing works
“H2O2 is the best described signaling molecule (Finkel 2011, Reczek & Chandel 2015).”
Background
A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide‐Induced Toxicity
Sule, R. O., Condon, L., & Gomes, A. V. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5563759 · Cited by 614 · see citing works
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
Wiel, C., Le Gal, K., Ibrahim, M. X., Jahangir, C. A., Kashif, M., Yao, H., Ziegler, D. V., Xu, X., Ghosh, T., Mondal, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.005 · Cited by 579 · see citing works
Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction
Ranji‐Burachaloo, H., Gurr, P. A., Dunstan, D. E., & Qiao, G. G. (2018) · ACS Nano · doi:10.1021/acsnano.8b07635 · Cited by 563 · see citing works
Cold atmospheric plasma, a novel promising anti-cancer treatment modality
Yan, D., Sherman, J. H., & Keidar, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13304 · Cited by 545 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Reactive Oxygen Species in the Immune System
Yang, Y., Bazhin, A. V., Werner, J., & Karakhanova, S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.755176 · Cited by 508 · see citing works
Theranostic Fluorescent Probes
Sharma, A. K., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 510 · see citing works
Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases
Kowalczyk, P., Sulejczak, D., Kleczkowska, P., Bukowska‐Ośko, I., Kucia, M., Popiel, M., Wietrak, E., Kramkowski, K., Wrzosek, K., & Kaczyńska, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413384 · Cited by 528 · see citing works
Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies
Moradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514 · see citing works
Mitochondria and cell signalling
Tait, S. W. G., & Green, D. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.099234 · Cited by 453 · see citing works
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Paulsen, C. E., Truong, T. H., García, F., Homann, A., Gupta, V., Leonard, S. E., & Carroll, K. S. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.736 · Cited by 473 · see citing works
Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival
Navarro-Yepes, J., Burns, M., Anandhan, A., Khalimonchuk, O., Razo, L. M. D., Quintanilla‐Vega, B., Pappa, A., Panayiotidis, M. I., & Franco, R. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5837 · Cited by 453 · see citing works
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
Nissanka, N., & Moraes, C. T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12956 · Cited by 453 · see citing works
An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires
Vernekar, A. A., Sinha, D., Srivastava, S., Paramasivam, P. U., D’Silva, P., & Mugesh, G. (2014) · Nature Communications · doi:10.1038/ncomms6301 · Cited by 441 · see citing works
Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection
Srinivasan, S., Guha, M., Kashina, A., & Avadhani, N. G. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.01.004 · Cited by 435 · see citing works
Cellular Mechanisms of Aortic Aneurysm Formation
Quintana, R. A., & Taylor, W. R. (2019) · Circulation Research · doi:10.1161/circresaha.118.313187 · Cited by 438 · see citing works
Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field
Katerji, M., Filippova, M., & Duerksen-Hughes, P. J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1279250 · Cited by 435 · see citing works
Oxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, R. K., Patel, A., Shah, N., Chaudhary, A. K., Jha, U. K., Yadav, U. C., Gupta, P. K., & Pakuwal, U. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.11.4405 · Cited by 432 · see citing works
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.013 · Cited by 430 · see citing works
Acquiring control: The evolution of ROS-Induced oxidative stress and redox signaling pathways in plant stress responses
Farooq, M. A., Niazi, A. K., Akhtar, J., Saifullah, Farooq, M., Souri, Z., Karimi, N., & Rengel, Z. (2019) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2019.04.039 · Cited by 412 · see citing works
Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease
Liby, K. T., & Sporn, M. B. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004846 · Cited by 410 · see citing works
Base excision repair: A critical player in many games
Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401 · see citing works
Roles of Autophagy in Oxidative Stress
Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 403 · see citing works
Redox and NF‐&kgr;B signaling in osteoarthritis
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Authors: Finkel, T.
Affiliations: National Institutes of Health (US)
Corresponding author: Finkel, Toren
ORCID: Finkel, Toren
Venue: Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2011-07-11
Volume: 194
Issue: 1
Pages: 7-15
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.201102095
PMC: PMC3135394
OpenAlex: W2115708356
Cited by: 2,322
References: 100
Citations by year: 2026: 90 · 2025: 120 · 2024: 134 · 2023: 166 · 2022: 187 · 2021: 223 · 2020: 187 · 2019: 188 · 2018: 130 · 2017: 168 · 2016: 161 · 2015: 164 · 2014: 155 · 2013: 129 · 2012: 107
FWCI: 11.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: reactive oxygen species, redox signaling, cysteine oxidation, post-translational modification, intracellular signaling, growth factor signaling, inflammation, disease
MeSH terms: Animals, Humans, Models, Biological, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species

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