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Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication
Abstract
Acetylation of histone H3 lysine 56 (H3-K56) occurs in S phase, and cells lacking H3-K56 acetylation are sensitive to DNA-damaging agents. However, the histone acetyltransferase (HAT) that catalyzes global H3-K56 acetylation has not been found. Here we show that regulation of Ty1 transposition gene product 109 (Rtt109) is an H3-K56 HAT. Cells lacking Rtt109 or expressing rtt109 mutants with alterations at a conserved aspartate residue lose H3-K56 acetylation and exhibit increased sensitivity toward genotoxic agents, as well as elevated levels of spontaneous chromosome breaks. Thus, Rtt109, which shares no sequence homology with any other known HATs, is a unique HAT that acetylates H3-K56.
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Cites
Scholes, D. T., Banerjee, M., Bowen, B., & Curcio, M. J. (2001) · Genetics · doi:10.1093/genetics/159.4.1449 · Cited by 235
Cited by
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
“A yeast protein SPT10 may be mediating acetylation of H3K56 at the promoters of histone genes to regulate gene expression (Xu et al., 2005), whereas the Rtt109 acetyltransferase mediates this modification more globally (Han et al., 2007; Driscoll et al., 2007; Schneider et al., 2006).”
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956
Yang, X.-J., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210599 · Cited by 940
Lateral Thinking: How Histone Modifications Regulate Gene Expression
Lawrence, M., Daujat, S., & Schneider, R. (2016) · Trends in Genetics · doi:10.1016/j.tig.2015.10.007 · Cited by 908
CBP/p300-mediated acetylation of histone H3 on lysine 56
Das, C., Lucia, M. S., Hansen, K. C., & Tyler, J. K. (2009) · Nature · doi:10.1038/nature07861 · Cited by 697
Metadata
- Authors
- Han, J., Zhou, H., Horazdovsky, B., Zhang, K., Xu, R.-M., & Zhang, Z.
- Venue
- Science
- Published
- 2007-02-02
- Volume
- 315
- Issue
- 5812
- Pages
- 653-655
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990103859
- Cited by
- 421
- References
- 1
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Han, J., Zhou, H., Horazdovsky, B., Zhang, K., Xu, R.-M., & Zhang, Z. (2007). Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication. Science. https://doi.org/10.1126/science.1133234
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