The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reversible Unfolding of Single RNA Molecules by Mechanical Force
Abstract
Here we use mechanical force to induce the unfolding and refolding of single RNA molecules: a simple RNA hairpin, a molecule containing a three-helix junction, and the P5abc domain of the Tetrahymena thermophila ribozyme. All three molecules (P5abc only in the absence of Mg 2+ ) can be mechanically unfolded at equilibrium, and when kept at constant force within a critical force range, are bi-stable and hop between folded and unfolded states. We determine the force-dependent equilibrium constants for folding/unfolding these single RNA molecules and the positions of their transition states along the reaction coordinate.
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Cites
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550
Cited by
Single-molecule mechanics of mussel adhesion
Lee, H., Scherer, N. F., & Messersmith, P. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605552103 · Cited by 2,112
Recent Advances in Optical Tweezers
Moffitt, J. R., Chemla, Y. R., Smith, S. B., & Bustamante, C. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.043007.090225 · Cited by 1,084
Self-citationVerification of the Crooks fluctuation theorem and recovery of RNA folding free energies
Collin, D., Ritort, F., Jarzynski, C., Smith, S. B., Tinoco, I., & Bustamante, C. (2005) · Nature · doi:10.1038/nature04061 · Cited by 1,049
Self-citationThe chemical repertoire of natural ribozymes
Doudna, J. A., & Cech, T. R. (2002) · Nature · doi:10.1038/418222a · Cited by 745
Woodside, M. T., Behnke-Parks, W. M., Larizadeh, K., Travers, K., Herschlag, D., & Block, S. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511048103 · Cited by 474
Metadata
- Authors
- Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I., & Bustamante, C.
- Venue
- Science
- Published
- 2001-04-27
- Volume
- 292
- Issue
- 5517
- Pages
- 733-737
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2162310257
- Cited by
- 931
- References
- 1
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I., & Bustamante, C. (2001). Reversible Unfolding of Single RNA Molecules by Mechanical Force. Science. https://doi.org/10.1126/science.1058498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
