The DOI matches its Crossref record.
A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii
Abstract
Toxoplasma gondii strains differ dramatically in virulence despite being genetically very similar. Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence of the type I lineage. Positional cloning identified the candidate virulence gene ROP18 , a highly polymorphic serine-threonine kinase that was secreted into the host cell during parasite invasion. Transfection of the virulent ROP18 allele into a nonpathogenic type III strain increased growth and enhanced mortality by 4 to 5 logs. These attributes of ROP18 required kinase activity, which revealed that secretion of effectors is a major component of parasite virulence.
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Citations
Cited by
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Sidik, S. M., Huet, D., Ganesan, S. M., Huynh, M.-H., Wang, T., Nasamu, A. S., Thiru, P., Saeij, J. P. J., Carruthers, V. B., Niles, J. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.019 · Cited by 804
Are some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 329
Modulators of the Balance between M1 and M2 Macrophages during Pregnancy
Zhang, Y.-H., He, M., Wang, Y., & Liao, A.-H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00120 · Cited by 292
Invasion and intracellular survival by protozoan parasites
David Sibley, L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00990.x · Cited by 254
Innate responses to Toxoplasma gondii in mice and humans
Pifer, R., & Yarovinsky, F. (2011) · Trends in Parasitology · doi:10.1016/j.pt.2011.03.009 · Cited by 139
Metadata
- Authors
- Taylor, S., Barragan, A., Su, C., Fux, B., Fentress, S. J., Tang, K., Beatty, W. L., Hajj, H. E., Jerome, M., Behnke, M. S., White, M., Wootton, J. C., & Sibley, L. D.
- Venue
- Science
- Published
- 2006-12-15
- Volume
- 314
- Issue
- 5806
- Pages
- 1776-1780
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015293161
- Cited by
- 545
- References
- 0
- FWCI
- 22.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taylor, S., Barragan, A., Su, C., Fux, B., Fentress, S. J., Tang, K., Beatty, W. L., Hajj, H. E., Jerome, M., Behnke, M. S., White, M., Wootton, J. C., & Sibley, L. D. (2006). A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii. Science. https://doi.org/10.1126/science.1133643
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
