The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Modulators of the Balance between M1 and M2 Macrophages during Pregnancy
Open accessAbstract
Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal-fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including regulation of immune cell activities, decidualization, placental cell invasion, angiogenesis, parturition, and postpartum uterine involution. The activation state and function of uterine-placental macrophages are largely dependent on the local tissue microenvironment. However, disruption of the uterine microenvironment can have profound effects on macrophage activity and subsequently impact pregnancy outcome. Thus, appropriately and timely regulated macrophage polarization has been considered a key determinant of successful pregnancy. Targeting macrophage polarization might be an efficient strategy for maintaining maternal-fetal immune homeostasis and a normal pregnancy. Here, we will review the latest findings regarding the modulators regulating macrophage polarization in healthy pregnancies and pregnancy complications, which might provide a basis for macrophage-centered therapeutic strategies.
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1 retracted
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Cited by
Palma, A., Jarrah, A. S., Tieri, P., Cesareni, G., & Castiglione, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01659 · Cited by 122
Garcia-Flores, V., Romero, R., Miller, D., Xu, Y., Done, B., Veerapaneni, C., Leng, Y., Arenas-Hernandez, M., Khan, N., Panaitescu, B., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01291 · Cited by 71
ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages
Janks, L., Sprague, R. S., & Egan, T. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801101 · Cited by 45
Wang, J.-L., Liang, Q.-L., Li, T.-T., He, J.-J., Bai, M.-J., Cao, X.-Z., Elsheikha, H. M., & Zhu, X.-Q. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900410 · Cited by 35
Metadata
- Authors
- Zhang, Y.-H., He, M., Wang, Y., & Liao, A.-H.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-02-09
- Volume
- 8
- Pages
- 120-120
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2586115964
- Cited by
- 292
- References
- 118
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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