The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
α-Klotho as a Regulator of Calcium Homeostasis
Abstract
α -klotho was identified as a gene associated with premature aging–like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) and provide evidence for an increase of abundance of Na + ,K + -ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca 2+ ] e ) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na + ,K + -ATPase–dependent manner. The increased Na + gradient created by Na + ,K + -ATPase activity might drive the transepithelial transport of Ca 2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Self-citationSuppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,850
Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,596
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Kaplan, J. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.102201.141218 · Cited by 1,181
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Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
Watanabe, H., Davis, J. B., Smart, D., Jerman, J. C., Smith, G. D., Hayes, P., Vriens, J., Cairns, W., Wissenbach, U., Prenen, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200062200 · Cited by 605
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Self-citation
Research works printed but not linked: 4
- 10.1016/0076-6879(88)56023-8 · doi:10.1016/0076-6879(88)56023-8
- J. P. Bilezikian R. Marcus M. A. Levine Eds. The Parathyroids: Basic and Clinical Concepts (Academic Press San Diego CA 2005).
- F. R. Bringhurst M. B. Demay H. M. Kronenberg William's Textbook of Endocrinology (Saunders Philadelphia ed. 9 2003).
- 10.1172/JCI200419081 · DOI
Cited by
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070
“…primary cause of the progeroid phenotypes of Klothodeficient mice is not known, but Klotho mediates calciumregulated parathyroid hormone secretion (Imura et al., 2007), stimulates FGF signaling in the kidney (Urakawa et al., 2006), and dampens WNT signaling (Liu et al., 2007); the unopposed WNT…”
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945
Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
Bergwitz, C., & Jüppner, H. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.051308.111339 · Cited by 741
The Klotho proteins in health and disease
Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707
Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700
Metadata
- Authors
- Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., Tomiyama, K.-I., Iijima, J., Nabeshima, Y., Fujioka, M., Asato, R., Tanaka, S., Kojima, K., Ito, J., Nozaki, K., Hashimoto, N., Ito, T., Nishio, T., Uchiyama, T., Fujimori, T., & Nabeshima, Y.-I.
- Venue
- Science
- Published
- 2007-06-15
- Volume
- 316
- Issue
- 5831
- Pages
- 1615-1618
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121270324
- Cited by
- 384
- References
- 24
- FWCI
- 20.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., Tomiyama, K.-I., Iijima, J., Nabeshima, Y., Fujioka, M., Asato, R., Tanaka, S., Kojima, K., Ito, J., Nozaki, K., . . . Nabeshima, Y.-I. (2007). α-Klotho as a Regulator of Calcium Homeostasis. Science. https://doi.org/10.1126/science.1135901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
