Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
Open accessAbstract
Although members of the fibroblast growth factor (FGF) family and their receptors have well-established roles in embryogenesis, their contributions to adult physiology remain relatively unexplored. Here, we use real-time quantitative PCR to determine the mRNA expression patterns of all 22 FGFs, the seven principal FGF receptors (FGFRs), and the three members of the Klotho family of coreceptors in 39 different mouse tissues. Unsupervised hierarchical cluster analysis of the mRNA expression data reveals that most FGFs and FGFRs fall into two groups the expression of which is enriched in either the central nervous system or reproductive and gastrointestinal tissues. Interestingly, the FGFs that can act as endocrine hormones, including FGF15/19, FGF21, and FGF23, cluster in a third group that does not include any FGFRs, underscoring their roles in signaling between tissues. We further show that the most recently identified Klotho family member, Lactase-like, is highly and selectively expressed in brown adipose tissue and eye and can function as an additional coreceptor for FGF19. This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KLB expression is primarily restricted to specific metabolic tissues (liver, pancreas, adipose) and lower in brain; KLB is not expressed in muscle.
“KLB expression is primarily restricted to specific metabolic tissues (for example, the liver, pancreas and adipose tissue)5, and lower expression is observed in the brain22,48–50. Despite some reports to the contrary51,52, KLB is not expressed in muscle5,41.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [5]
FGF21 is an endocrine hormone produced and secreted predominantly by the liver, unlike traditional FGFs.
“FGF21, unlike traditional FGFs, is an endocrine hormone produced and secreted predominantly by the liver [129,130].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [130]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Self-citationFGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works
Self-citationKlotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,871 · see citing works
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works
Self-citationInagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Self-citationShimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503 · see citing works
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391 · see citing works
Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368 · see citing works
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*
Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K., Baum, M., Schiavi, S., Hu, M.-C., Moe, O., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,356 · see citing works
Self-citationFgf10 is essential for limb and lung formation
Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N., et al. (1999) · Nature Genetics · doi:10.1038/5096 · Cited by 1,283 · see citing works
Structural and functional diversity in the FGF receptor multigene family.
Johnson, D. E., & Williams, L. (1993) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60821-0 · Cited by 1,270 · see citing works
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164 · see citing works
Self-citationEvolution of the Fgf and Fgfr gene families.
Itoh, N., & Ornitz, D. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.08.007 · Cited by 1,123 · see citing works
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.049 · Cited by 1,015 · see citing works
Self-citationThe parathyroid is a target organ for FGF23 in rats
Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951 · see citing works
Self-citationIdentification of a novel FGF, FGF-21, preferentially expressed in the liver
Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847 · see citing works
Gospodarowicz, D. (1974) · Nature · doi:10.1038/249123a0 · Cited by 788 · see citing works
Miki, T., Bottaro, D., Fleming, T., Smith, C. L., Burgess, W., Chan, A., & Aaronson, S. (1992) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.89.1.246 · Cited by 757 · see citing works
Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works
Self-citationStructural basis for fibroblast growth factor receptor activation
Mohammadi, M., Olsen, S. K., & Ibrahimi, O. A. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.008 · Cited by 737 · see citing works
Self-citationRegulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
Yamamoto, M., Clark, J. D., Pastor, J. V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillón, D. H., Rosenblatt, K. P., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509039200 · Cited by 727 · see citing works
Self-citationFGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.
Ohuchi, H., Hori, Y., Yamasaki, M., Harada, H., Sekine, K., Kato, S., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.2000.3721 · Cited by 663 · see citing works
βKlotho is required for metabolic activity of fibroblast growth factor 21
Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617 · see citing works
Self-citationFu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 580 · see citing works
Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.5.8850 · Cited by 576 · see citing works
Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553 · see citing works
Goetz, R., Beenken, A., Ibrahimi, O., Kalinina, J., Olsen, S., Eliseenkova, A. V., Xu, C.-F., Neubert, T., Zhang, F.-M., Linhardt, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 544 · see citing works
Self-citationFGFR‐4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
Partanen, J., Mäkelä, T., Eerola, E., Korhonen, J., Hirvonen, H., Claesson-Welsh, L., & Alitalo, K. (1991) · EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07654.x · Cited by 511 · see citing works
Bovi, P. D., Curatola, A. M., Kern, F. G., Greco, A., Ittmann, M., & Basilico, C. (1987) · Cell · doi:10.1016/0092-8674(87)90331-x · Cited by 507 · see citing works
Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX
Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505 · see citing works
Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497 · see citing works
Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 490 · see citing works
FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
Weinstein, M. B., Xu, X., Ohyama, K., & Deng, C. (1998) · Development · doi:10.1242/dev.125.18.3615 · Cited by 485 · see citing works
Miyamoto, M., Naruo, K., Seko, C., Matsumoto‐Yoshitomi, S., Kondo, T., & Kurokawa, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4251-4259.1993 · Cited by 422 · see citing works
Fibroblast growth factors and their receptors in the central nervous system
Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 412 · see citing works
Functional evolutionary history of the mouse Fgf gene family
Itoh, N., & Ornitz, D. M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21388 · Cited by 409 · see citing works
Kolek, O. I., Hines, E. R., Jones, M. D., LeSueur, L., Lipko, M. A., Kiela, P. R., Collins, J. F., Haussler, M. R., & Ghishan, F. K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2005 · Cited by 408 · see citing works
High‐Throughput Real‐Time Quantitative Reverse Transcription PCR
Bookout, A. L., Cummins, C. L., Mangelsdorf, D. J., Pesola, J. M., & Kramer, M. F. (2006) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb1508s73 · Cited by 401 · see citing works
Self-citationTanaka, A., Miyamoto, K., Minamino, N., Takeda, M., Sato, B., Matsuo, H., & Matsumoto, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.8928 · Cited by 398 · see citing works
Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice
Falardeau, J., Chung, W. C. J., Beenken, A., Raivio, T., Plummer, L., Sidis, Y., Jacobson-Dickman, E. E., Eliseenkova, A. V., Ma, J., Dwyer, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34538 · Cited by 397 · see citing works
Self-citationα-Klotho as a Regulator of Calcium Homeostasis
Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., et al. (2007) · Science · doi:10.1126/science.1135901 · Cited by 385 · see citing works
Yu, C., Wang, F., Kan, M., Jin, C., Jones, R. B., Weinstein, M., Deng, C.-X., & Mckeehan, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15482 · Cited by 357 · see citing works
Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.
Ulich, T. R., Yi, E. S., Longmuir, K. J., Yin, S., Biltz, R., Morris, C. F., Housley, R. M., & Pierce, G. F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117086 · Cited by 351 · see citing works
Suzuki, M., Uehara, Y., Motomura-Matsuzaka, K., Oki, J., Koyama, Y., Kimura, M., Asada, M., Komi-Kuramochi, A., Oka, S., & Toru, T. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0313 · Cited by 345 · see citing works
FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho
Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 329 · see citing works
A role for FGF-6 in skeletal muscle regenerationPreprint
Floß, T., Arnold, H.-H., & Braun, T. W. (1997) · Genes & Development · doi:10.1101/gad.11.16.2040 · Cited by 328 · see citing works
Ito, S., Kinoshita, S., Shiraishi, N., Nakagawa, S., Sekine, S., Fujimori, T., & Nabeshima, Y. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00439-1 · Cited by 312 · see citing works
Igarashi, M., Finch, P. W., & Aaronson, S. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13230 · Cited by 307 · see citing works
Identification of a hormonal basis for gallbladder filling
Choi, M., Moschetta, A., Bookout, A., Peng, L., Umetani, M., Holmstrom, S. R., Suino-Powell, K., Xu, H. E., Richardson, J., Gerard, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1501 · Cited by 289 · see citing works
Self-citationLiver-specific Activities of FGF19 Require Klotho beta
Lin, B. C., Wang, M., Blackmore, C. A., & Desnoyers, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704244200 · Cited by 284 · see citing works
Goldfarb, M., Schoorlemmer, J., Williams, A. J., Diwakar, S., Wang, Q., Huang, X., Giza, J. I., Tchetchik, D., Kelley, K., Vega, A. V., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.006 · Cited by 266 · see citing works
Desnoyers, L. R., Pai, R., Ferrando, R., Hotzel, K., Le, T., Ross, J., Carano, R., D'Souza, A., Qing, J., Mohtashemi, I., et al. (2008) · Oncogene · doi:10.1038/sj.onc.1210623 · Cited by 266 · see citing works
Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho
Ito, S., Fujimori, T., Furuya, A., Satoh, J., Nabeshima, Y., & Nabeshima, Y. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23076 · Cited by 248 · see citing works
Alpha-Klotho as a regulator of calcium homeostasis
Tsuji, Y. (2008) · Kyoto University Research Information Repository (Kyoto University) · Cited by 243 · see citing works
Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb
Revest, J., Suniara, R. K., Kerr, K., Owen, J. J. T., & Dickson, C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1954 · Cited by 242 · see citing works
Fibroblast growth factor homologous factors: evolution, structure, and function.
Goldfarb, M. (2005) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2005.02.002 · Cited by 234 · see citing works
Itoh, N. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1819 · Cited by 224 · see citing works
Keratinocyte growth factor and its receptor are involved in regulating early lung branching
Post, M., Souza, P., Liu, J., Tseu, I., Wang, J., Kuliszewski, M. J., & Tanswell, A. K. (1996) · Development · doi:10.1242/dev.122.10.3107 · Cited by 172 · see citing works
Mohammadi, M., Olsen, S. K., & Goetz, R. M. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.09.002 · Cited by 158 · see citing works
Self-citationRegulation of thymic epithelium by keratinocyte growth factor
Erickson, M., Morkowski, S., Lehar, S. M., Gillard, G. O., Beers, C., Dooley, J., Rubin, J. S., Rudensky, A. Y., & Farr, A. G. (2002) · Blood · doi:10.1182/blood-2002-04-1036 · Cited by 154 · see citing works
Patterning of frontal cortex subdivisions by Fgf17
Cholfin, J. A., & Rubenstein, J. L. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702225104 · Cited by 154 · see citing works
Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18
Ohbayashi, N., Hoshikawa, M., Kimura, S., Yamasaki, M., Fukui, S., & Itoh, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18161 · Cited by 152 · see citing works
FGF23 is a hormone-regulating phosphate metabolism—Unique biological characteristics of FGF23
Fukumoto, S., & Yamashita, T. (2007) · Bone · doi:10.1016/j.bone.2006.12.062 · Cited by 148 · see citing works
Yano, T., Mason, R. J., Pan, T., Deterding, R. R., Nielsen, L. D., & Shannon, J. M. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1146 · Cited by 146 · see citing works
Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart
Hartung, H. D., Feldman, B., Lovec, H., Coulier, F., Birnbaum, D., & Goldfarb, M. P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00042-7 · Cited by 140 · see citing works
Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling
Wu, X., Ge, H., Gupte, J., Weiszmann, J., Shimamoto, G., Stevens, J., Hawkins, N., Lemon, B., Shen, W., Xu, J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700130200 · Cited by 140 · see citing works
Ohmachi, S., Watanabe, Y., Mikami, T., Kusu, N., Ibi, T., Akaike, A., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3675 · Cited by 139 · see citing works
MacArthur, C. A., Shankar, D. B., & Shackleford, G. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2501-2507.1995 · Cited by 139 · see citing works
Wu, D., Kan, M., Sato, G. H., Okamoto, T., & Sato, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55368-0 · Cited by 131 · see citing works
Cotton, L. M., O’Bryan, M. K., & Hinton, B. T. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0028 · Cited by 129 · see citing works
Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA.
Bovi, P. D., & Basilico, C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5660 · Cited by 125 · see citing works
Quantitative analysis of estrogen receptor-? mRNA and its variants in human breast cancers
Iwao, K., Miyoshi, Y., Egawa, C., Ikeda, N., & Noguchi, S. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001201)88:5 · Cited by 124 · see citing works
Beer, H., Florence, C., Dammeier, J., McGuire, L., Werner, S., & Duan, D. R. (1997) · Oncogene · doi:10.1038/sj.onc.1201383 · Cited by 122 · see citing works
Junior, J. B., Teixeira, A. B., da Costa, I. B., Glapinski, V. F., Pinto, M. G. L., Giometti, I. C., Barros, C. M., Cao, M., Nicola, E. S., & Price, C. A. (2005) · Reproduction · doi:10.1530/rep.1.00642 · Cited by 122 · see citing works
Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling
Pai, R., Dunlap, D. Y., Qing, J., Mohtashemi, I., Hötzel, K., & French, D. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2325 · Cited by 121 · see citing works
Abnormal social behaviors in mice lacking Fgf17
Scearce-Levie, K. A., Roberson, E. D., Gerstein, H. C., Cholfin, J. A., Mandiyan, V. S., Shah, N. M., Rubenstein, J. L. R., & Mucke, L. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00357.x · Cited by 113 · see citing works
Mutations within the FGF5 gene are associated with hair length in cats
Drögemüller, C., Rüfenacht, S., Wichert, B. A., & Leeb, T. (2007) · Animal Genetics · doi:10.1111/j.1365-2052.2007.01590.x · Cited by 108 · see citing works
Ito, S., Fujimori, T., Hayashizaki, Y., & Nabeshima, Y. (2002) · Biochimica et Biophysica Acta · doi:10.1016/s0167-4781(02)00281-6 · Cited by 108 · see citing works
The fibroblast growth factor-binding protein FGF-BP.
Abuharbeid, S., Czubayko, F., & Aigner, A. (2006) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2005.10.017 · Cited by 105 · see citing works
Hoshikawa, M., Ohbayashi, N., Yonamine, A., Konishi, M., Ozaki, K., Fukui, S., & Itoh, N. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8239 · Cited by 103 · see citing works
Naruo, K., Seko, C., Kuroshima, K., Matsutani, E., Sasada, R., Kondo, T., & Kurokawa, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53852-7 · Cited by 98 · see citing works
Beer, H., Bittner, M., Niklaus, G., Munding, C., Max, N., Goppelt, A., & Werner, S. (2005) · Oncogene · doi:10.1038/sj.onc.1208560 · Cited by 98 · see citing works
Wang, Q., McEwen, D. G., & Ornitz, D. M. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00241-5 · Cited by 94 · see citing works
Ohmachi, S., Mikami, T., Konishi, M., Miyake, A., & Itoh, N. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10592 · Cited by 94 · see citing works
Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.
Haub, O., Drucker, B. J., & Goldfarb, M. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8022 · Cited by 87 · see citing works
Kehler, J., David, V. A., Schäffer, A. A., Bajema, K. L., Eduardo Eizirik, C., Ryugo, D. K., Hannah, S. S., O’Brien, S. J., & Menotti-Raymond, M. A. (2007) · Journal of Heredity · doi:10.1093/jhered/esm072 · Cited by 87 · see citing works
Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart
Hotta, Y., Sasaki, S., Konishi, M., Kinoshita, H., Kuwahara, K., Nakao, K., & Itoh, N. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21726 · Cited by 78 · see citing works
Armand, A., Laziz, I., & Chanoine, C. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.06.005 · Cited by 77 · see citing works
Suzuki, S. O., Kato, T., Takimoto, H., Masui, S., Oshima, H., Ozawa, K., Suzuki, S., & Imamura, T. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00427.x · Cited by 76 · see citing works
Beer, H., Vindevoghel, L., Gait, M., Revest, J., Duan, D. R., Mason, I. J., Dickson, C., & Werner, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16091 · Cited by 75 · see citing works
Fgf19 is required for zebrafish lens and retina development
Nakayama, Y., Miyake, A., Nakagawa, Y., Mido, T., Yoshikawa, M., Konishi, M., & Itoh, N. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.11.013 · Cited by 69 · see citing works
Mayshar, Y., Rom, E., Chumakov, I., Kronman, A., Yayon, A., & Benvenisty, N. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1037 · Cited by 67 · see citing works
Aberrant fibroblast growth factor receptor signaling in bladder and other cancers
Chaffer, C. L., Dopheide, B., Savagner, P., Thompson, E. W., & Williams, E. D. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00210.x · Cited by 66 · see citing works
Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract
Vincentz, J. W., Mcwhirter, J., Murre, C., Baldini, A., & Furuta, Y. (2005) · Genesis · doi:10.1002/gene.20114 · Cited by 66 · see citing works
Fibroblast growth factor 22 and its potential role during skin development and repair.
Beyer, T. A., Werner, S., Dickson, C., & Grose, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00139-3 · Cited by 62 · see citing works
Expression of fibroblast growth factors in thyroid cancer
Eggo, M. C., Hopkins, J., Franklyn, J. A., Johnson, G. D., Sanders, D. S. A., & Sheppard, M. C. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7533768 · Cited by 62 · see citing works
Thompson, S. D., Franklyn, J. A., Watkinson, J. C., Verhaeg, J. M., Sheppard, M. C., & Eggo, M. C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4723 · Cited by 62 · see citing works
Study of Fgf15 gene expression in developing mouse brain
Gimeno, L. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00059-0 · Cited by 59 · see citing works
Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain
Todo, T., Kondo, T., Nakamura, S., Kirino, T., Kurokawa, T., & Ikeda, K. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01340-1 · Cited by 54 · see citing works
Emerging role of the FGF system in psychiatric disorders
Riva, M. A., Molteni, R., Bedogni, F., Racagni, G., & Fumagalli, F. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.03.001 · Cited by 52 · see citing works
Calbindin 1, fibroblast growth factor 20, and α-synuclein in sporadic Parkinson’s disease
Mizuta, I., Tsunoda, T., Satake, W., Nakabayashi, Y., Watanabe, M., Takeda, A., Hasegawa, K., Nakashima, K., Yamamoto, M., Hattori, N., et al. (2008) · Human Genetics · doi:10.1007/s00439-008-0525-5 · Cited by 51 · see citing works
Fehrenbach, H., Kasper, M. E., Koslowski, R., Pan, T., Schuh, D., Müller, M., & Mason, R. J. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180000157 · Cited by 48 · see citing works
FGF-10 Is a Growth Factor for Preadipocytes in White Adipose Tissue
Yamasaki, M., Emoto, H., Konishi, M., Mikami, T., Ohuchi, H., Nakao, K., & Itoh, N. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0594 · Cited by 46 · see citing works
Moore, D. D. (2007) · Science · doi:10.1126/science.1144837 · Cited by 45 · see citing works
Basic fibroblast growth factor: an autocrine mitogen of rat thyroid follicular cells?
Logan, A., Black, E. G., Gonzalez, A. M., Buscaglia, M., & Sheppard, M. C. (1992) · Endocrinology · doi:10.1210/endo.130.4.1312454 · Cited by 43 · see citing works
Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice
Yamamoto, H., Ochiya, T., Takahama, Y., Ishíi, Y., Osumi, N., Sakamoto, H., & Terada, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203752 · Cited by 42 · see citing works
Endocrine fibroblast growth factors as regulators of metabolic homeostasis
Kurosu, H., & Kuro‐o, M. (2009) · BioFactors · doi:10.1002/biof.12 · Cited by 42 · see citing works
Self-citationFGF19‐FGFR4 signaling elaborates lens induction with the FGF8‐L‐Maf cascade in the chick embryo
Kurose, H., Okamoto, M., Shimizu, M., Bito, T., Marcelle, C., Noji, S., & Ohuchi, H. (2005) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2005.00795.x · Cited by 37 · see citing works
Characterization of INT-2: A member of the fibroblast growth factor family
Dickson, C., Acland, P., Smith, R., Dixon, M., Deed, R. W., MacAllan, D., Walther, W., Fuller-Pace, F. V., Kiefer, P., & Peters, G. G. (1990) · Journal of Cell Science · doi:10.1242/jcs.1990.supplement_13.9 · Cited by 29 · see citing works
Sasaki, H., Hirai, K., Yamamoto, H., Tanooka, H., Sakamoto, H., Iwamoto, T., Takahashi, T., Terada, M., & Ochiya, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207348 · Cited by 23 · see citing works
The Fibroblast Growth Factor Family and Mood Disorders
Akil, H., Evans, S. J., Turner, C. A., Perez, J., Myers, R., Bunney, W. E., Jones, E. G., & Watson, S. J. (2008) · Novartis Foundation symposium · doi:10.1002/9780470751251.ch8 · Cited by 19 · see citing works
Impairment of hippocampal long-term potentiation by Alzheimer amyloid ?-peptides
Chen, Q.-S., Kagan, B. L., Hirakura, Y., & Xie, C.-W. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000401)60:1
Flagged first, then by citations
1 of the 116 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
Bispecific antibodies: a mechanistic review of the pipeline
Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303 · see citing works
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works
Gut-liver axis: Pathophysiological concepts and clinical implications
Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843 · see citing works
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
Itoh, N., & Ornitz, D. M. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq121 · Cited by 708 · see citing works
The Klotho proteins in health and disease
Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707 · see citing works
Self-citationThe therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Geng, L., Lam, K. S. L., & Xu, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0386-0 · Cited by 607 · see citing works
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
Chiang, J. Y. L., & Ferrell, J. M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00223.2019 · Cited by 580 · see citing works
Exploring mechanisms of FGF signalling through the lens of structural biology
Goetz, R., & Mohammadi, M. (2013) · Nature reviews. Molecular cell biology · doi:10.1038/nrm3528 · Cited by 556 · see citing works
Self-citationFGF21 regulates metabolism and circadian behavior by acting on the nervous system
Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works
Self-citationActivation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy
Grabner, A., Amaral, A. P., Schramm, K. J., Singh, S., Sloan, A. J., Yanucil, C., Li, J., Shehadeh, L. A., Hare, J. M., David, V., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.002 · Cited by 546 · see citing works
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works
Self-citationHu, M. C., Shiizaki, K., Kuro-o, M., & Moe, O. W. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183727 · Cited by 587 · see citing works
Self-citationFGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works
Self-citationThe role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Sun, L., Cai, J., & Gonzalez, F. J. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00404-2 · Cited by 443 · see citing works
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works
Self-citationTherapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403 · see citing works
Self-citationDegradation of AMPK by a Cancer-Specific Ubiquitin Ligase
Pineda, C. T., Ramanathan, S., Fon Tacer, K., Weon, J. L., Potts, M. B., Ou, Y.-H., White, M. A., & Potts, P. R. (2015) · Cell · doi:10.1016/j.cell.2015.01.034 · Cited by 389 · see citing works
Singh, S., Grabner, A., Yanucil, C., Schramm, K. J., Czaya, B. A., Krick, S., Czaja, M. J., Bartz, R., Abraham, R., Marco, G. S. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.019 · Cited by 361 · see citing works
FGF21 as Modulator of Metabolism in Health and Disease
Tezze, C., Romanello, V., & Sandri, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00419 · Cited by 313 · see citing works
Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works
Bispecific Antibodies: From Research to Clinical Application
Ma, J., Mo, Y., Tang, M., Shen, J., Qi, Y., Zhao, W., Huang, Y., Xu, Y., & Qian, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626616 · Cited by 309 · see citing works
Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives
Woo, Y. C., Xu, A., Wang, Y., & Lam, K. S. L. (2012) · Clinical Endocrinology · doi:10.1111/cen.12095 · Cited by 302 · see citing works
Bile acid signaling pathways from the enterohepatic circulation to the central nervous system
Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287 · see citing works
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286 · see citing works
Self-citationA PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Jonker, J., Suh, J. M., Atkins, A., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T., et al. (2012) · Nature · doi:10.1038/nature10998 · Cited by 286 · see citing works
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works
Kidney and eye diseases: Common risk factors, etiological mechanisms, and pathways
Wong, C. W., Wong, T. Y., Cheng, C.-Y., & Sabanayagam, C. (2014) · Kidney International · doi:10.1038/ki.2013.491 · Cited by 276 · see citing works
Biomarkers of diabetic kidney disease
Colhoun, H. M., & Marcovecchio, M. L. (2018) · Diabetologia · doi:10.1007/s00125-018-4567-5 · Cited by 274 · see citing works
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works
Harrison, S. A., Frias, J. P., Neff, G., Abrams, G. A., Lucas, K. J., Sanchez, W., Gogia, S., Sheikh, M. Y., Behling, C., Bedossa, P., et al. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00272-8 · Cited by 276 · see citing works
Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.005 · Cited by 261 · see citing works
Self-citationBile acids and their receptors in metabolic disorders
Fiorucci, S., Distrutti, E., Carino, A., Zampella, A., & Biagioli, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101094 · Cited by 262 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00075 · Cited by 252 · see citing works
Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J., & Scheja, L. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.006 · Cited by 252 · see citing works
Ren, Y., Zhao, H., Yin, C., Lan, X., Wu, L., Du, X., Griffiths, H. R., & Gao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873699 · Cited by 246 · see citing works
An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease
Lee, E., Korf, H., & Vidal‐Puig, A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.024 · Cited by 228 · see citing works
Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221 · see citing works
Machado, S. A., Pasquarelli-do-Nascimento, G., da Silva, D. S., Farias, G. R., Santos, I. D. O., Baptista, L. B., & Magalhães, K. G. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00694-0 · Cited by 229 · see citing works
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology · doi:10.1210/en.2014-2001 · Cited by 215 · see citing works
Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works
Foltz, I. N., Hu, S., King, C., Wu, X., Yang, C., Wang, W., Weiszmann, J., Stevens, J., Chen, J. S., Nuanmanee, N., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004690 · Cited by 211 · see citing works
Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.
Angelin, B., Larsson, T., & Rudling, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.001 · Cited by 210 · see citing works
Biological Role of Anti-aging Protein Klotho
Kim, J., Hwang, K., Park, K., Kong, I. D., & Cha, S. (2015) · Journal of Lifestyle Medicine · doi:10.15280/jlm.2015.5.1.1 · Cited by 204 · see citing works
FGF23 Actions on Target Tissues—With and Without Klotho
Richter, B., & Faul, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00189 · Cited by 204 · see citing works
Geng, L., Liao, B., Jin, L., Huang, Z. P., Triggle, C. R., Ding, H., Zhang, J., Huang, Y., Lin, Z., & Xu, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.014 · Cited by 201 · see citing works
Díaz-Delfín, J., Hondares, E., Iglesias, R., Giralt, M., Caelles, C., & Villarroya, F. (2012) · Endocrinology · doi:10.1210/en.2012-1193 · Cited by 195 · see citing works
Molecular basis of bile acid-FXR-FGF15/19 signaling axis
Katafuchi, T., & Makishima, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116046 · Cited by 193 · see citing works
Silswal, N., Touchberry, C. D., Daniel, D., McCarthy, D. L., Zhang, S., Andresen, J. J., Stubbs, J. R., & Wacker, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00264.2014 · Cited by 189 · see citing works
Ryan, K. K., Kohli, R., Gutierrez-Aguilar, R., Gaitonde, S. G., Woods, S. C., & Seeley, R. J. (2013) · Endocrinology · doi:10.1210/en.2012-1891 · Cited by 185 · see citing works
Wu, A.-L., Coulter, S., Liddle, C., Wong, A., Eastham‐Anderson, J., French, D. M., Peterson, A. S., & Sonoda, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017868 · Cited by 185 · see citing works
Wu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184 · see citing works
Timper, K., del Río-Martín, A., Cremer, A. L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.001 · Cited by 170 · see citing works
Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
Yang, C., Jin, C., Li, X., Wang, F., McKeehan, W. L., & Luo, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033870 · Cited by 173 · see citing works
Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150050 · Cited by 171 · see citing works
Kuro-o, M. (2012) · Current opinion in nephrology and hypertension · doi:10.1097/mnh.0b013e32835422ad · Cited by 175 · see citing works
Self-citationGoing Back to the Biology of FGF21: New Insights
Lewis, J. E., Ebling, F. J. P., Samms, R. J., & Tsintzas, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.05.007 · Cited by 164 · see citing works
Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.008 · Cited by 166 · see citing works
Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Fernández‐Barrena, M. G., Urtasun, R., Elizalde, M., Bárcena‐Varela, M., Jiménez, M., Chang, H. C. Y., Barbero, R., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312975 · Cited by 164 · see citing works
Evolving concepts in the pathogenesis of uraemic cardiomyopathy
Wang, X., & Shapiro, J. I. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0101-8 · Cited by 162 · see citing works
Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., & Hillgartner, F. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375907 · Cited by 161 · see citing works
Kuro‐o, M. (2011) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2011.26.2.113 · Cited by 157 · see citing works
Self-citationWang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works
Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
Hansen, H. H., Ægidius, H. M., Oró, D., Evers, S. S., Heebøll, S., Eriksen, P. L., Thomsen, K. L., Bengtsson, A., Veidal, S. S., Feigh, M., et al. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01356-2 · Cited by 157 · see citing works
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes
Looker, H. C., Colombo, M., Hess, S., Brosnan, M. J., Farran, B., Dalton, R. N., Wong, M. C., Turner, C., Palmer, C. N. A., Nogoceke, E., et al. (2015) · Kidney International · doi:10.1038/ki.2015.199 · Cited by 152 · see citing works
Wöhrle, S., Bonny, O., Beluch, N., Gaulis, S., Stamm, C., Scheibler, M., Müller, M. M., Kinzel, B., Thuery, A., Brueggen, J., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.478 · Cited by 152 · see citing works
Roles of FGF Signals in Heart Development, Health, and Disease
Itoh, N., Ohta, H., Nakayama, Y., & Konishi, M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00110 · Cited by 152 · see citing works
Fibroblast growth factor-21, energy balance and obesity
Giralt, M., Gavaldà‐Navarro, A., & Villarroya, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.018 · Cited by 146 · see citing works
FGF21 reloaded: challenges of a rapidly growing field
Kharitonenkov, A., & Larsen, P. J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.11.003 · Cited by 147 · see citing works
New developments in the biology of fibroblast growth factors
Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works
Zweers, S. J. L. B., Booij, K. A. C., Komuta, M., Roskams, T., Gouma, D. J., Jansen, P. L. M., & Schaap, F. G. (2011) · Hepatology · doi:10.1002/hep.24702 · Cited by 141 · see citing works
Li, X. (2019) · Frontiers of Medicine · doi:10.1007/s11684-019-0711-y · Cited by 139 · see citing works
Wang, S., Wang, Y., Zhang, Z., Liu, Q., & Gu, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.410 · Cited by 139 · see citing works
Fibroblast Growth Factor Signaling in Metabolic Regulation
Nies, V. J. M., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R. T., Atkins, A. R., Evans, R. M., Jonker, J. W., & Downes, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00193 · Cited by 135 · see citing works
Metabolic Messengers: fibroblast growth factor 15/19
Gadaleta, R. M., & Moschetta, A. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0074-3 · Cited by 137 · see citing works
FGF21 Is an Exocrine Pancreas Secretagogue
Coate, K. C., Hernandez, G., Thorne, C. A., Sun, S., Le, T. D. V., Vale, K., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.004 · Cited by 136 · see citing works
Self-citationAcute exercise increases fibroblast growth factor 21 in metabolic organs and circulation
Tanimura, Y., Aoi, W., Takanami, Y., Kawai, Y., Mizushima, K., Naito, Y., & Yoshikawa, T. (2016) · Physiological Reports · doi:10.14814/phy2.12828 · Cited by 131 · see citing works
Stress-induced FGF21 and GDF15 in obesity and obesity resistance
Keipert, S., & Ost, M. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.08.008 · Cited by 131 · see citing works
Zhang, F., Yu, L., Lin, X., Cheng, P., He, L., Li, X., Lu, X., Tan, Y., Yang, H., Cai, L., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1155 · Cited by 130 · see citing works
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics
Abraham, C. R., & Li, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101766 · Cited by 130 · see citing works
Zhou, M., Learned, R. M., Rossi, S. J., DePaoli, A. M., Tian, H., & Ling, L. (2015) · Hepatology · doi:10.1002/hep.28257 · Cited by 128 · see citing works
Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit
Kim, B., Kanai, M. I., Oh, Y., Kyung, M., Kim, E., Jang, I.-H., Lee, J.-H., Kim, S., Suh, G. S. B., & Lee, W. (2021) · Nature · doi:10.1038/s41586-021-03522-2 · Cited by 127 · see citing works
FGF21 and Cardiac Physiopathology
Planavila, A., Redondo-Angulo, I., & Villarroya, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00133 · Cited by 123 · see citing works
Kim, S. H., Kim, K. H., Kim, H.-K., Kim, M.-J., Back, S. H., Konishi, M., Itoh, N., & Lee, M.-S. (2015) · Diabetologia · doi:10.1007/s00125-014-3475-6 · Cited by 124 · see citing works
Pathophysiological roles of FGF signaling in the heart
Itoh, N., & Ohta, H. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00247 · Cited by 122 · see citing works
Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
Hansen, J. S., Clemmesen, J. O., Secher, N. H., Hoene, M., Drescher, A., Weigert, C., Pedersen, B. K., & Plomgaard, P. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.001 · Cited by 123 · see citing works
Fibroblast growth factor 21: a regulator of metabolic disease and health span
Xie, T., & Leung, P. S. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2017 · Cited by 121 · see citing works
Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy
Itoh, N., Ohta, H., & Konishi, M. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00154 · Cited by 119 · see citing works
Chen, S., Chen, S., Sun, Y., Xu, Z., Wang, Y., Yao, S., Yao, W., & Gao, X. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101133 · Cited by 119 · see citing works
Tissue expression and source of circulating αKlotho
Olauson, H., Mencke, R., Hillebrands, J., & Larsson, T. E. (2017) · Bone · doi:10.1016/j.bone.2017.03.043 · Cited by 118 · see citing works
Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers
Naugler, W. E., Tarlow, B., Fedorov, L. M., Taylor, M. J., Pelz, C., Li, B., Darnell, J. C., & Grompe, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.043 · Cited by 115 · see citing works
Fibroblast Growth Factor 15/19: From Basic Functions to Therapeutic Perspectives
Somm, E., & Jornayvaz, F. R. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00134 · Cited by 117 · see citing works
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
Yang, C., Lu, W., Lin, T., You, P., Ye, M., Huang, Y., Jiang, X., Wang, C., Wang, F., Lee, M., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-67 · Cited by 117 · see citing works
Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
Domouzoglou, E. M., Naka, K. Κ., Vlahos, A. P., Papafaklis, M. I., Michalis, L. K., Tsatsoulis, A., & Maratos–Flier, E. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00527.2015 · Cited by 115 · see citing works
- Authors
- Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., & Kliewer, S. A.
- Affiliations
- Department of Molecular Biology (K.F.T., X.D., S.A.K.), Dallas, Texas 75390
- Howard Hughes Medical Institute (US)
- Department of Pathology (H.K., G.B.J., L.W., M.K.), Dallas, Texas 75390
- New York University (US)
- Corresponding author
- Mangelsdorf, David J.
- Kliewer, Steven A.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-10-01
- Volume
- 24
- Issue
- 10
- Pages
- 2050-2064
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC2954642
- OpenAlex
- W1968091833
- Cited by
- 700
- References
- 116
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 46 · 2023: 48 · 2022: 53 · 2021: 68 · 2020: 52 · 2019: 64 · 2018: 55 · 2017: 41 · 2016: 45 · 2015: 53 · 2014: 28 · 2013: 32 · 2012: 35
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (I-1558, I-1275)
- Welch Foundation (I-1275, I-1558, GM007062)
- National Institutes of Health (I-1275, I-1558, DK067158, U19DK62434, AG19712)
- National Institute on Aging (AG-19712, R01AG019712)
- National Institute of General Medical Sciences (T32GM007062, GM007062, RL1GM084436)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-067158, U19 DK-62434, U19DK062434, R01DK067158)
- National Institute of Dental and Craniofacial Research (DE13686, R01DE013686)
- National Center for Research Resources (P20RR20691, P20RR020691)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- fibroblast growth factor, fibroblast growth factor receptor, FGF19, FGF21, fibroblast growth factor 23, FGF15/19, tissue-specific gene expression, adult mice, brown adipose tissue, hormone signaling, central nervous system
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Atlases as Topic, Fibroblast Growth Factors, Humans, Mice, Inbred C57BL, RNA, Messenger, Tissue Distribution, Cluster Analysis, Receptors, Fibroblast Growth Factor, Gene Expression Profiling, Microarray Analysis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review