The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Computational Design of Peptides That Target Transmembrane Helices
Abstract
A variety of methods exist for the design or selection of antibodies and other proteins that recognize the water-soluble regions of proteins; however, companion methods for targeting transmembrane (TM) regions are not available. Here, we describe a method for the computational design of peptides that target TM helices in a sequence-specific manner. To illustrate the method, peptides were designed that specifically recognize the TM helices of two closely related integrins (α IIb β 3 and α v β 3 ) in micelles, bacterial membranes, and mammalian cells. These data show that sequence-specific recognition of helices in TM proteins can be achieved through optimization of the geometric complementarity of the target-host complex.
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Cites
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution
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Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli
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A Transmembrane Helix Dimer: Structure and Implications
MacKenzie, K. R., Prestegard, J. H., & Engelman, D. M. (1997) · Science · doi:10.1126/science.276.5309.131 · Cited by 954
Pegylation: A Novel Process for Modifying Pharmacokinetics
Harris, J. M., Martin, N. E., & Modi, M. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140070-00005 · Cited by 913
Structural Basis of Integrin Activation by Talin
Wegener, K. L., Partridge, A. W., Han, J., Pickford, A. R., Liddington, R. C., Ginsberg, M. H., & Campbell, I. D. (2007) · Cell · doi:10.1016/j.cell.2006.10.048 · Cited by 676
Senes, A., Gerstein, M., & Engelman, D. M. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3488 · Cited by 598
INTEGRIN STRUCTURE, ALLOSTERY, AND BIDIRECTIONAL SIGNALING
Arnaout, M. A., Mahalingam, B., & Xiong, J.-P. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.090704.151217 · Cited by 550
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Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs
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Self-citationSequence determinants of amyloid fibril formation
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Cited by
Structure and mechanics of integrin-based cell adhesion
Arnaout, M. A., Goodman, S. L., & Xiong, J.-P. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.08.002 · Cited by 403
Drugging Membrane Protein Interactions
Yin, H., & Flynn, A. D. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092115-025322 · Cited by 339
Self-citationProtein Design: From the Aspect of Water Solubility and Stability
Qing, R., Hao, S., Smorodina, E., Jin, D., Zalevsky, A., & Zhang, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00757 · Cited by 312
Predicting the Impact of Missense Mutations on Protein–Protein Binding Affinity
Li, M., Petukh, M., Alexov, E., & Panchenko, A. R. (2014) · Journal of Chemical Theory and Computation · doi:10.1021/ct401022c · Cited by 111
Challenges in the computational design of proteins
Suárez, M., & Jaramillo, A. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0508.focus · Cited by 59
Metadata
- Authors
- Yin, H., Slusky, J. S., Berger, B. W., Walters, R. S., Vilaire, G., Litvinov, R. I., Lear, J. D., Caputo, G. A., Bennett, J. S., & DeGrado, W. F.
- Venue
- Science
- Published
- 2007-03-30
- Volume
- 315
- Issue
- 5820
- Pages
- 1817-1822
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050749891
- Cited by
- 289
- References
- 35
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yin, H., Slusky, J. S., Berger, B. W., Walters, R. S., Vilaire, G., Litvinov, R. I., Lear, J. D., Caputo, G. A., Bennett, J. S., & DeGrado, W. F. (2007). Computational Design of Peptides That Target Transmembrane Helices. Science. https://doi.org/10.1126/science.1136782
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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