The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75 NTR
Abstract
Differentiation of hepatic stellate cells (HSCs) to extracellular matrix– and growth factor–producing cells supports liver regeneration through promotion of hepatocyte proliferation. We show that the neurotrophin receptor p75 NTR , a tumor necrosis factor receptor superfamily member expressed in HSCs after fibrotic and cirrhotic liver injury in humans, is a regulator of liver repair. In mice, depletion of p75 NTR exacerbated liver pathology and inhibited hepatocyte proliferation in vivo. p75 NTR –/– HSCs failed to differentiate to myofibroblasts and did not support hepatocyte proliferation. Moreover, inhibition of p75 NTR signaling to the small guanosine triphosphatase Rho resulted in impaired HSC differentiation. Our results identify signaling from p75 NTR to Rho as a mechanism for the regulation of HSC differentiation to regeneration-promoting cells that support hepatocyte proliferation in the diseased liver.
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Citations
Cites
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
Yamashita, T., & Tohyama, M. (2003) · Nature Neuroscience · doi:10.1038/nn1045 · Cited by 460
Cited by
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Pathogenesis of Liver Fibrosis
Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Metadata
- Authors
- Passino, M. A., Adams, R. A., Sikorski, S. L., & Akassoglou, K.
- Venue
- Science
- Published
- 2007-03-30
- Volume
- 315
- Issue
- 5820
- Pages
- 1853-1856
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027954852
- Cited by
- 180
- References
- 3
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Passino, M. A., Adams, R. A., Sikorski, S. L., & Akassoglou, K. (2007). Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75 NTR. Science. https://doi.org/10.1126/science.1137603
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